Dear Editor Re: Developing longitudinal qualitative designs: lessons learned and recommendations for health services research Manuscript ID: 1077421626669504 Thank you for your letter informing us of your decision and forwarding us the constructive reviews made by the three reviewers. We have worked further on this paper and we have addressed all issues raised by the reviewers. We hope the changes made are satisfactory. We are, of course, happy to make more revisions if necessary. Below we outline how we have addressed each point raised. Yours Sincerely Professor Alex Molassiotis University of Manchester Reviewers’ comments Our response Reviewer 1: OVERALL I read this manuscript with great interest because I am very interested in qualitative methods, in learning about cutting-edge advancements in methods, and in how qualitative research can be reported in ways that make it more relevant to decision makers, including clinicians, managers and policy makers. While the content reads well and the findings are relevant and important to anyone doing qualitative research, not only those using longitudinal qualitative designs, the textual information could potentially be organized, summarized and extended to highlight the findings and expand on the implications. That would make the paper easier to read, and more easily “translatable” to practice by researchers and decision makers. We have re-organised the paper and we have followed the reviewer’s suggestions. We have also under more headings/subheading to make the flow of paper easier. MAJOR COMPULSORY REVISIONS Methods Although this is an experiential account, We have added a short section in p.8 it is not clear upon what it is based. describing the process of developing this Obviously it is based on the experiences paper. of the researchers, but how did they identify these themes or come to agreement on which themes to describe and how. So while the account is of a qualitative nature, many readers will judge the relevance or reliability of the findings based on what they know of how these recommendations were assembled. Include a Methods section in which there is some description of how themes were identified, documented, discussed, elaborated, and how recommendations were generated. There are formal methods achieving consensus and generating recommendations. I don’t think that formal methods are needed here, but a more precise account of the thinking and activity that led to the recommendations is warranted. Following are more specific suggestions. Results The narrative, while well written, is very extensive and may therefore be challenging to absorb. While some subtitles are used, I would recommend additional titles and sub-titles to more easily guide the reader through this wealth of information and more clearly highlight key points so that they are distinct. For example, under Practical and ethical issues, many such issues are discussed, and perhaps many of these are thought by the authors to be ethical issues, because only in the last paragraph for this sub-section is the concept of practical difficulties mentioned. How are these conceptually different from those in subsequent sections, many of which appear to be methodological and logistical. So consider reviewing this information and elaborating on the use of titles and subtitles to reflect and distinguish key themes. You might also further We have addressed this by amending headings, removing ‘practical’ from the ‘practical and ethical’ headings that reflect separately now issues related to researchers and participants and amended the order of the text to reflect this. distinguish themes as those that affect researchers or those that affect patients. A summary table would also be useful. Consider columns for key themes/issues, definitions, example from author’s research, and suggested solutions. In this way the reader is more easily able to take away important suggestions. In my view the recommendations are part of the results, rather than concluding remarks. The purpose of the paper is to provide guidance on how to integrate multidimensional data that arises from longitudinal qualitative research. So the issues and potential solutions discussed throughout the Results section give rise to a number of higher-level recommendations. Many points arose in the Results that do not appear to be addressed in the Recommendations so the Recommendations could be expanded, and included in the Results section. Discussion Include a more elaborate Discussion section that first briefly summarizes the findings, then note limitations in the methods used to generate the findings and of the findings themselves. Next contextualize the findings with respect to other research in a more general or high level manner than in the Introduction, for example, there is much controversy among qualitative researchers in qualitative methods, how do these findings clarify or add to those debates, and in what way does this research add to our knowledge about qualitative methods. Next extend the discussion of the implications of the findings. For example, the findings are important because they provide guidance on a method that can be used to better describe what works and does not work with respect to complex health care interventions that may be either clinical care delivery or quality improvements to the organization and delivery of health services. Conclude with the existing We have added a table and this on p.910. Recommendations have now been moved to results and expanded. The Discussion has now been re-written based on the reviewer’s comments and at the same time being succinct to avoid making the Discussion unnecessarily long. suggestions for ongoing research. Then a Conclusions section can offer a brief summary and next steps. MINOR ESSENTIAL REVISIONS Title – lessons learned? Rather than These have now been all revised in the learnt? paper. Some wording is awkward and perhaps an anomaly of cutting and pasting? For example: Introduction, first paragraph: “…pathway whether that be to long term survivor…” Page 5, “Different approaches have been taken to collection and analysis of data for example use longitudinal data to…” Page 6, “…experience over time, for example, McCann et al [16].” What about McCann?? Reviewer 2 Thank you for the opportunity to review this paper. It considers the lessons learnt from using longitudinal qualitative methods (LQR) in a health care setting, and makes recommendations for their future use. LQR is an emerging methodology and one being increasingly employed in health service research, and so this paper is timely and covers an important area where more knowledge is needed. The paper is well written, and clearly structured and referenced. The authors correctly highlight several areas which are currently problematic, and make use of reflection upon their own experiences to form recommendations for addressing these. It is important to share these experiences and I believe other researchers considering using this approach would find this paper very useful indeed. We thank the reviewer for the positive comments. There are no issues identified to address related to this review. Reviewer 3: Major Compulsory Revisions I feel that much of the issues commented on within the paper are general to qualitative health research and the We have added more practical examples from our experience, and this is throughout the paper. practical issues discussed are common problems in research that have already been addressed elsewhere. Overall, there are not enough practical examples using research evidence demonstrated within the paper. I would like to see better evidence of how LQR worked for the authors and what they achieved from using this methodology. This would add more strength to their argument. Data collection 1. Whist many practical issues are discussed around ethical considerations, there seems to be a lack of practical guidance on serial interviews in the data collection section of the paper; it would be useful to see a sample of interview questions or a description of the types of interview questions that could be asked. I suggest a table be included in the data collection section with types of questions and examples that have been used. We have now given examples of how the analysis was done, but we felt adding exemplary patient quotes and the themes found in each cancer group would be repetitive, as these are already presented in the relevant papers [refs 1825]. Instead, after a summary and broad examples of analysis, we are referring the reader to the actual study papers, plus a new paper of ours were we metasynthesised all qualitative literature on symptom experiences in cancer patients and the various themes are outlined there [ref 39]. Analysis 2. I feel this section needs to include some evidence of how longitudinal qualitative data analysis was applied and what it achieved for the authors. It would be useful to see practical examples of how some data were analysed. It would be useful to include some extracts of data or summary of themes and examples of how they were interpreted. Paragraph 6 3. It would be useful to include a This is now in the Discussion and description of the new of the new insights conclusions more clearly. that the authors claim to have been highlighted from their analyses. Minor Essential Revisions I have no suggestions here Discretionary Revisions Practical and Ethical issues, paragraph 5 We have deleted this section, as 4. It may be worthwhile taking out the last suggested. seven lines on this paragraph beginning with We did consider inviting participants to a presentation……… I feel this is would be so difficult to put in practice for ethical reasons and therefore, is not worth mentioning in this paper.