BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Antonio Valencia
Instructor in Neurology
Assistant in Neuroscience
eRA COMMONS USER NAME
AVALENCIA1
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Faculty of Sciences, UNAM. Mexico City
Institute of Cellular Physiology, UNAM. Mexico
City (Honors)
Wellman Center for Photomedicine, MGH-HMS.
Boston, MA
MassGeneral Institute for Neurodegenerative
Disease, MGH. Charlestown, MA
DEGREE
(if applicable)
YEAR(s)
B.S.
1990-1997
Biology
Ph.D.
1999-2003
Neuroscience
2003-2006
Cell Biology
206-2010
Neuroscience
Postdoctoral
training
Postdoctoral
training
FIELD OF STUDY
A. POSITIONS AND HONORS
Positions
2010- present Assistant in Neuroscience, MassGeneral Institute for Neurodegenerative Disease, MGH.
Charlestown, MA
2010-present Instructor in Neurology Harvard Medical School
2011-2012
Animal Behavior Testing Advisory Committee. MassGeneral Institute for Neurodegenerative
Disease. Massachusetts General Hospital. Charlestown, MA.
2012-present Co-Director of the Mouse Behavior
Neurodegenerative Disease, MGH. Charlestown, MA
Honors
1999-2004.
2000 -2004.
2000.
Core
at
MIND.
MassGeneral
Institute
for
Ph.D. Scholarship from the National Council for Science and Technology, Mexico.
Ph.D. Scholarship from the National University of Mexico (DGEP-UNAM).
First place for best work in the 5th Annual Ph.D. Students Neuroscience Meeting, Barcelona, Spain.
2000-2001
Research Award for Scientific collaboration in the Department of Biochemistry and Molecular
Biology. Autonomous University of Barcelona. Laboratory of Dr. Jose Rodriguez. Barcelona, Spain. Role of
IP3-kinase and Akt in the apoptotic cell death induced by oxidative stress in cultured neurons. Funded by
General Division for Professionals Studies (DGEP)-National University of Mexico and the National Council for
Science and Technology (CONACyT)-Mexico.
2001
Research award for Scientific collaboration in the Department of Physiology, Faculty of
Medicine. Autonomous University of San Luis Potosi. Laboratory of Dr. Sergio SanchezArmass. San Luis Potosi, Mexico. Relation between intracellular pH and intracellular calcium in
the apoptotic cell death of neurons in culture. Founded by General Division for Professionals
Studies (DGEP)-National University of Mexico and the National Council for Science and
Technology (CONACyT)-Mexico.
2000, 2002.
Lecturer in “Apoptosis and diseases”. Biomedical Sciences Ph.D. Program. Institute of Cellular
Physiology, National University of Mexico.
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2002-2003.
2003.
2004.
2003-2008.
2008-2012.
Lecturer in “Biochemistry and Molecular Biology”. Faculty of Medicine, National University of
Mexico
Doctoral dissertation with Honors.
Travel Award in the 11th Meeting of Society for Free Radical Biology and Medicine. St. Thomas US
Virgin Islands. Awarded by competitive selection prior to and during the meeting.
Foundation Mexico in Harvard grant-fellowship award for postdoctoral studies.
Milton Wexler Posdoctoral Fellowship Award. Hereditary Disease Foundation.
Memberships in Scientific Association and other scientific experience
1999.
2000.
2000.
2004.
Mexican Society for Biochemistry.
International Society for Neuroscience.
Mexican Society of Development Biology.
Society for Free Radical Biology and Medicine.
Ad hoc revisions for:
American Journal of Physiology, Cell Physiology, Cell Calcium, Cytoskeleton, Biochemistry, Physiological
Genomics, Neurobiology of Disease, Apoptosis, Neurobiology of Aging
Memberships in Scientific Association and other scientific experience
1999.
2000.
2000.
2004.
Mexican Society for Biochemistry.
International Society for Neuroscience.
Mexican Society of Development Biology.
Society for Free Radical Biology and Medicine.
B. PUBLICATIONS (selected)
1.Valencia, A. and Moran, J. Reactive oxygen species induce different cell death mechanisms in
cultured neurons. Free Radical Biol Med. (2004) 36(9):1112-1125.
2.Franco-Cea, A., Valencia, A., Sanchez-Armass, S., Dominguez, G. and Moran, J. Role of ionic fluxes
in the apoptotic cell death of cultured cerebellar granule neurons. Neurochem Res. (2004) 29(1):22738.
3.Valencia, A. and Kochevar, I.E. UVA induces apoptosis via reactive oxygen species in a model for
Smith-Lemli-Opitz syndrome. Free Radical Biol Med. (2006) 40:641-650.
4.Valencia, A. and Kochevar, I.E. Nox1-Based NADPH Oxidase is the Major Source of UVA-Induced
Reactive Oxygen Species in Human Keratinocytes. J Invest Dermatol (2008) 28(1):214-222.
5.Coyoy, A., Valencia, A., Guemez-Gamboa, A., and Moran, J. Role of NADPH-oxidase in the
apoptotic death of cultured cerebellar granule neurons. Free Radical Biol Med. (2008) 45: 1056-1064.
6.Li, X., Sapp, E., Valencia, A., Kegel, K.B. Quin, Z.H., Alexander, J., Masso, N., Ritch, J.J., Zeitlin, S.,
Aronin, N. and DiFiglia, M. A function of Huntingtin in guanine nucleotide exchange on Rab11.
Neuroreport. (2008). Oct 29;19(16):1643-7.
7.Kegel K.B., Sapp E., Alexander J., Valencia A., Reeves P.B., Li X., Masso N., Sobin L., Aronin N.
and DiFiglia M. Polyglutamine expansion in Huntingtin alters interaction with phospholipids. Journal of
Neurochemistry. (2009). Sep;110(5):1585-97.
8.Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A,
Esteves M, Aronin N, Difiglia M. Disruption of Rab11 activity in a knock-in mouse model of
Huntington’s disease. Neurobiology of Disease. (2009). Nov;36(2):374-83.
9.Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M,
Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, Difiglia M.
Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11
Activity. Molecular and Cellular Biology. (2009). Nov;29(22):6106-16. PMCID: PMC2772576.
10.Valencia A., Reeves P.B., Sapp E., Li X., Alexander J., Kegel K.B., Chase K., Aronin N. and
DiFiglia M. Mutant huntingtin accumulates in neuronal lipid rafts in of a pre-symptomatic mouse
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model of Huntington’s disease. Journal of Neuroscience Research. (2010). Jan;88(1):179-90.
11.Li X.*, Valencia A.*, Sapp E., Masso N., Alexander J., Reeves P., Kegel K.B., Aronin N., and DiFiglia
M. Aberrant Rab11-dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes
Oxidative Stress and Cell Death in Huntington's Disease. Journal of Neuroscience. (2010). March 31,
2010, 30(13):4552-4561. *Equal contribution.
12.Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H,
Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, Aronin N, Paganetti P, Difiglia
M. Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.
Molecular Neurodegeneration. (2010). Dec; 14(5)-1:58.
13.Valencia A., Reeves P.B., Sapp E., Li X., Alexander J., Masso N., Li X., Kegel and DiFiglia M.
Reagents that curb neuronal death from Huntington’s disease also curb oxidative stress. Neuroreport.
(2012). Jan;4,23(1):10-15.
14.Sapp E., Valencia A., Li X., Aronin N., Kegel K.B., VOnsattel JP., Young A.B., Wexler N. and DiFiglia
M. Native mutant huntingtin human brain: evidence for prevalence of full length monomer. Journal of
Biological Chemistry. (2012) 287(16):13487-99.
15.Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S,
Sadri-Vakili G, Irimia D, Difiglia M, Kegel KB. Multiple phenotypes in Huntington’s disease mouse
neuronal stem cells. Mol Cell Neurosci. 2012 May; 50(1):70-81.
16.Li, Valencia A, McClory H, Sapp E, Kegel KB and DiFiglia M. Deficient Rab11 activity underlies
glucose hypometabolism in primary neurons of Huntington’s disease mice. Biochem Biphys Res
Comm. 2012. May 18; 421(4):727-30.
17.Valencia A, Sapp E, Kimm JS, McClory H, Reeves PB, Alexander J, Ansong KA, Masso N, Frosch
MP, Kegel KB, Li X and DiFiglia M. Elevated NADPH oxidase activity contributes to oxidative stress
and cell death in Huntington’s disease. Hum Mol Genet. 2012. In press. doi: 10.1093/hmg/dds516
Current support
NIH, 1 R01 NS074381-01
9/30/11-6/30/2015
Increase Rab11 Activity as HD therapy PI: M. DiFiglia
Role: investigator
Study of effects of dominant active Rab11 in HD mice and ability to rescue disease phenotypes.
Pending support
Grant submitted to Hereditary Disease Foundation
Title: “In vivo inhibition of oxidative stress by blocking NADPH oxidase inHuntington's disease”.
Role: Principal Investigator
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