記錄
編號
4955
狀態
NC092FJU00255018
助教
查核
索書
號
學校
名稱
輔仁大學
系所
名稱
食品營養學系
舊系
所名
稱
學號
491446182
研究
廖欣儀
生(中)
研究
Shin-Yi Liao
生(英)
論文
名稱
(中)
論文
名稱
(英)
腹腔注射高鋁對小鼠組織內多胺及鎂含量之影響
The effect of peritoneal aluminum overload on tissue polyamine and magnesium
contents in the mice
其他
題名
指導
教授
(中)
王果行
指導
教授
(英)
Guoo-shyng Wang Hsu
校內
全文
開放
日期
不公開
校外
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不開
放理
由
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全文 同意
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國圖.
國圖
全文 2004.06.09
開放
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電子
全文
01
學位
類別
碩士
畢業
學年
度
92
出版
年
語文
別
中文
關鍵
鋁 睪丸組織 多胺 鎂
字(中)
關鍵
aluminum testis tissue polyamine magnesium
字(英)
摘要
(中)
本研究之假說是鋁藉由降低多胺 (polyamines；PAs) 及鎂離子濃度，導致
過多的一氧化氮產物 (nitric oxide product；NOx) 聚積在組織內，增加氧
化壓力。實驗採用二十四隻雄性 ICR 小白鼠分為控制組、低鋁組及高鋁
組，每日分別腹腔注射每公斤體重 0, 7, 35 mg 鋁 14 天後，比較血液及臟
器中鋁、鎂、多胺 (putrescine, spermine, spermidine)、NOx 濃度及各指標
之相關性。結果顯示小白鼠血清、肝臟、睪丸及副睪中鋁含量隨鋁劑量
增加而升高，血清鋁濃度分別與睪丸及肝臟鋁濃度呈正相關 (r = 0.875, r
= 0.863, P < 0.0001)，且血清、肝臟與睪丸內鎂濃度與鋁濃度呈負相關 ( r
= -0.431, r = -0.585, r = -0.456, P < 0.05)，血清、肝臟與睪丸 NOx 濃度則與
鋁濃度呈正相關 (r = 0.423, r = 0.540, r = 0.486, P < 0.05)。雖然睪丸組織中
主要調控多胺分解的二胺氧化酶活性與鋁濃度呈正相關 (r = 0.441, P <
0.05)，睪丸中鋁濃度與 putrescine 濃度呈負相關 (r = -0.60, P < 0.05)，但睪
丸組織之總多胺濃度在各組間並無明顯差異。因此小鼠體內鋁的堆積，
可能主要藉由降低小鼠體內鎂濃度，使得 NOx 生成量明顯增加。
摘要
(英)
論文
目次
The hypothesis of this study is that high aluminum (Al) causes the reduction of
tissue polyamines (PAs) and/or magnesium (Mg) contents, resulting in an increase
of inducible nitric oxide synthase (iNOS) and production of nitric oxide product
(NOx). Twenty-four male ICR mice were divided into three group, including
control (C), low Al (LAl) and high Al (HAl). Animals were intraperitoneally
injected of AlCl3 in the dosage of 0, 7, 35 mg Al/kg body wt/day respectively for
a period of 14 days. Blood and tissues’s Al, Mg, PAs (putrescine, spermine and
spermidine) and NOx contents were determined. Results indicated that serum,
liver, testis and epididymis Al contents were increased with the amount of Al
injected. Testicular and hepatic Al contents were markedly increased with
increasing serum levels of Al (r = 0.875, r = 0.863, P < 0.0001). In addition, Al
concentration was inversely related to the Mg concentration (r = -0.431, r = 0.585, r = -0.456, P < 0.05), and positively correlated with the levels of NOx (r =
0.423, r = 0.540, r = 0.486, respectively, P < 0.05) in serum, liver and testis. On
the other hand, the testicular diamine oxidase (DAO) activities which shared
features with the metabolism of PAs were positively related to the serum Al
concentrations (r = 0.441, p < 0.05). Testicular putrescine concentration
negatively correlated with the levels of Al (r = -0.60, P < 0.05). However,
testicular total PAs contents were not significantly influenced by Al concentration.
It was concluded that the increased production of NOx in Al overload mice may
be mainly through the Al-induced reduction of tissue Mg contents.
第一章 緒論-----------------------------------------------------------------------1 第二章
文獻回顧-----------------------------------------------------------------2 壹、鋁 1.1、
鋁的分佈------------------------------------------------------------2 1.2、鋁的應用與
來源---------------------------------------------------2 1.3、鋁的吸收與排泄--------------------------------------------------3 1.4、鋁毒性與疾病的關係--------------------------------------------4 1.5、鋁毒性對雄性生殖系統的影響--------------------------------6 貳、一氧化氮 2.1、一氧化氮的特性--------------------------------------------------6 2.2、過多的一氧化氮造成組織的傷害------------------------------8
2.3、高鋁誘導一氧化氮的生成----------------------------------------9 2.4、鎂、
鈣離子對一氧化氮生成的影響-----------------------------9 參、多胺 3.1、多胺
的特性-------------------------------------------------------11 3.2、多胺與一氧化氮
的關係----------------------------------------12 3.3、睪丸組織的營養狀況與多胺
的關係-------------------------12 第三章 研究目的與假說-----------------------------------------------------13 第四章 材料與方法 壹、動物飼養與處理 1.1、 飼
料配製--------------------------------------------------------18 1.2、 動物飼養-------------------------------------------------------18 1.3、 腹腔注射及劑量換算表-------------------------------------17 1.4、 注射溶液之配製--------------------------------------
---------19 貳、動物犧牲及樣品處理 2.1、動物犧牲---------------------------------------------------------20 2.2、分析樣品前處理------------------------------------------------21 參、分析項目與方法 3.1、鋁含量之測定---------------------------------------------------21 3.2、鎂含量之測定--------------------------------------------------22 3.3、鈣含量之測定---------------------------------------------------23 3.4、一
氧化氮產物之測定------------------------------------------24 3.5、多胺含量之分
析------------------------------------------------27 3.6、二胺氧化酶活性分析------------------------------------------28 肆、統計分析----------------------------------------------------------------30 第五章 結果 壹、腹腔注射氯化鋁對小鼠生長之影響------------------------------31 貳、腹腔注射氯化鋁對小鼠血液中一氧化氮、二
胺氧化酵素、鋁、鈣及鎂含量之影響---------------------------------------------------32 参、腹腔注射氯化鋁對小鼠肝臟中一氧化氮、鋁、鈣及鎂含量之
影響-------------------------------------------------------------------------32 肆、腹腔注
射氯化鋁對小鼠睪丸組織中一氧化氮、二胺氧化酵素、鋁、鈣及鎂含量
之影響----------------------------------------------33 伍、腹腔注射氯化鋁對小鼠
副睪中一氧化氮、二胺氧化酵素、鋁、鈣及鎂含量之影響---------------------------------------------------33 陸、腹腔注射氯化鋁對小鼠臟器多胺含量與睪
丸組織及副睪中二胺氧化酶活性之影響---------------------------------------------------34 第六章 討論 壹、腹腔注射氯化鋁對小鼠生長發育的影響------------------------63 貳、鋁毒性對小鼠血液及臟器中鋁、鈣及鎂等離子含量之
影響----------------------------------------------------------------------------64 参、鋁毒
性對小鼠血液及臟器中一氧化氮含量之影響--------------------------------------------------------------------------66 肆、鋁毒性降低小鼠體內鎂濃度促進一氧
化氮生成的可能機制探討-----------------------------------------------------------------------66 伍、鋁毒性對小鼠睪丸組織中二胺氧化酶活性與臟器多胺含量
之影響---------------------------------------------------------------------67 陸、多胺與
一氧化氮的關係---------------------------------------------68 第七章 結論-------------------------------------------------------------------69 第八章 參考文獻-------------------------------------------------------------71 表目錄 頁次 表一 腹腔注射氯化鋁對
小鼠生長之影響------------------------------36 表二 腹腔注射氯化鋁對小鼠血
清一氧化氮、鎂、鈣及鋁濃度與二胺氧化酶活性的影響----------------------------------------------37 表三 腹腔注射氯化鋁對小鼠肝臟一氧化氮、鎂、鈣
及鋁濃度的影響-----------------------------------------------------------------------38
表四 腹腔注射氯化鋁對小鼠睪丸一氧化氮、鎂、鈣及鋁濃度的影響----------------------------------------------------------------------39 表五 腹腔注射氯化鋁
對小鼠副睪一氧化氮、鎂、鈣及鋁濃度的影響----------------------------------------------------------------------40 表六 腹腔注射氯化鋁對小鼠肝臟
putrescine、spermidine 及 spermine 濃度之影響----------------------------------------------41 表七 腹腔注射氯化鋁對小鼠睪丸二胺氧化酶活性與
putrescine、spermidine 及 spermine 濃度之影響----------------------------42 表八
腹腔注射氯化鋁對小鼠副睪二胺氧化酶活性與 putrescine、spermidine 及
spermine 濃度之影響----------------------------43 圖目錄 圖一 多胺生成途徑---------------------------------------------------------44 圖二 多胺代謝途徑---------------------------------------------------------45 圖三 每日腹腔注射氯化鋁對小鼠體重
變化之影響-------------------46 圖四 小鼠肝臟鋁濃度與肝臟體重比之相關
性-------------------------47 圖五 小鼠血清鋁與肝臟鋁濃度之相關性------------------------------48 圖六 小鼠血清鋁與睪丸鋁濃度之相關性------------------------------49 圖七 小鼠血清鋁濃度與血清 NOx 濃度之相關性--------------------50 圖八 小鼠血清鋁濃度與血清鎂濃度之相關性-------------------------51 圖
九 小鼠血清鋁濃度與血清鈣濃度之相關性-------------------------52 圖十 小
鼠血清鎂濃度與血清 NOx 濃度之相關性---------------------53 圖十一 小鼠
肝臟鋁濃度與肝臟 NOx 濃度之相關性------------------54 圖十二 小鼠肝臟
鋁濃度與肝臟鎂濃度之相關性----------------------55 圖十三 小鼠肝臟鎂濃
度與肝臟 NOx 濃度之相關性------------------56 圖十四 小鼠睪丸鋁濃度與
睪丸 NOx 濃度之相關性------------------57 圖十五 小鼠睪丸鋁濃度與睪丸
鎂濃度之相關性----------------------58 圖十六 小鼠睪丸鎂濃度與睪丸 NOx
濃度之相關性------------------59 圖十七 小鼠睪丸鋁濃度與睪丸 DAO 活性
之相關性-----------------60 圖十八 小鼠睪丸鋁濃度與睪丸 putrescine 濃度之
相關性-----------61 圖十九 小鼠睪丸 putrescine 濃度與睪丸 DAO 活性之相
關性------62
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