Principal Investigator/Program Director (Last, First, Middle):
Li, Qian
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Qian Li
Postdoctoral Fellow in the Cancer Stem Cell
Laboratory, Johns Hopkins School of Medicine
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include
postdoctoral training.)
DEGREE
INSTITUTION AND LOCATION
YEAR(s)
FIELD OF STUDY
(if applicable)
Peking University, China
B.S.
2003-2007
Basic Medicine
Peking University, China
Ph.D.
2007-2011
Biochemistry and
Molecular Biology
Postdoctoral
fellow
2011-
Johns Hopkins University, Baltimore MD
Neuroscience
A. Personal Statement
I am a Postdoctoral Fellow in the Department of Neurosurgery at Johns Hopkins University School of Medicine. I
work in the Brain Tumor Stem Cell Laboratory directed by Dr. Alfredo Quinones-Hinojosa. I study Mesenchymal
Stem Cells (MSCs) and Brain Tumor Stem Cells (BTSCs) using molecular biology methods, cytology, and animal
models. My focus is using human Adipose-derived Mesenchymal Stem Cells (hAMSCs) as delivery vehicles to treat
glioblastoma (GB). The long term goal is to develop hAMSCs as an alternative therapy for patients with GB. I have a
broad background in cellular and molecular biology research and also a strong background in the oncology, which is
vital to accomplish my goals.
B. Positions and Honors
2007-11
2009-10
2011-
Ph.D. Student, Department of Biochemistry and Molecular Biology, Peking University, China.
Teaching experience as Assistant pre-doctoral student, Department of Biochemistry and Molecular Biology,
Peking University, China. Practical laboratory lessons in Methodology and Experimental Biochemistry in
Biology.
Postdoctoral Fellow, Neurosurgery and Oncology. Cancer Stem Cell laboratory and Department of
Neurosurgery, Johns Hopkins University.
Honors
2007-11
2007-08
2009-10
Ph.D. Student Scholarship from Peking University Health Science Center, Peking University, China.
Excellent Student of Peking University Health Science Center, Peking University, China.
Triple A Student Award of Peking University, Peking University, China.
C. Peer-reviewed publications (in chronological order)
1. Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang. Binding
of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells
by Repressing Chemokine CCL14. Cancer Research, 2011, 71(21): 6899–908.
PHS 398/2590 (Rev. 09/04)
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
Li, Qian
2. Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang, and Yongfeng Shang. SET8 promotes epithelial–
mesenchymal transition and confers TWIST dual transcriptional activities. The EMBO Journal, 2011,
doi:10.1038/emboj.2011.364.
3. Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han,
Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang. HAT4, a Golgi Apparatus-Anchored B-Type Histone
Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell, 2011, 44(1):3950.
4. Lei Shi1, Luyang Sun1, Qian Li, Jing Liang, Wenhua Yua, Xia Yia, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang,
Chenghao Xuan, Zhi Yao, and Yongfeng Shang. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation
and promotes hormonally responsive breast carcinogenesis. (L. Shi and L. Sun contributed equally to this work).
PNAS, 2010, 108(18):7541-6.
5. Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang,
Lei Shi, Ruifang Li, Yanyan Li, Yu Zhang, Qian Li, Xia Yi, Yongfeng Shang. LSD1 Is a Subunit of the NuRD
Complex and Targets the Metastasis Programs in Breast Cancer. Cell, 2009, 138: 660-672.
D. Research Support

Project Number: 2011CB504204
Project Period: 01/11- 12/15
P.I.: Yongfeng Shang
Role on Project: Ph.D. Student
Project Title: Mechanism of Epithelial–Mesenchymal Transition and Reprogram of Metastatic Cancer Cells.
Source: National Natural Science Foundation of China (973 Key Program), Ministry of Science and Technology
of China, China.

Project Number: 81071677
Project Period: 01/11- 12/13
P.I.: Wenhua Yu
Role on Project: Ph.D. Student
Project Title: Study of the Biologic Function and Molecular Mechanism of sZIP in Tumorigenesis.
Source: National Natural Science Foundation of China (General Program), Ministry of Science and Technology
of China, China.
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