Additional Supporting Information
Materials.
The monomers 2-(2-methoxyethoxy)ethyl methacrylate (MEO
2
MA, Aldrich 95%), 1-ethoxy-2-
(2-methoxy-ethoxy)-ethyl methacrylate (MEO
3
MA, Aldrich 95%) and oligo(ethylene glycol) methacrylate with side chains of 8/9 ethylene oxide units (MEO
8
MA, Aldrich 95%) were purified by passing through a neutral column to remove the antioxidant inhibitor. Unless otherwise noted, reagents were commercially available and used without further purification.
1,1,4,7,10,10-Hexamethyltriethylenetetramine (HMTETA, 99%, Aldrich), ethyl 2bromoisobutyrate (EBr i B, 99%, Aldrich), CuCl (99.999%, Aldrich), and the solvent benzonitrile
(99.6%, Panreac) were used as received. For the CdSe nanocrystals, trioctylphosphine oxide
(TOPO, 99%, Aldrich), selenium powder (Aldrich), trioctylphosphine (TOP, 97%, Aldrich), cadmium oxide brown (CdO, 99%, Fluka), 1-tetradecylphosphonic acid (TDPA, 98%, Alfa Aesar) and sodium methoxide (95%, Aldrich) were used as received. Solvents were dried by standard methods or by elution through a Pure Solv Innovative Technology column drying system.
Dialysis was carried out using a regenerate cellulose membrane tubing of MWCO 50kDa from
RC Spectra/Por®7-Spectrum Labs.
1

FIGURE S1 1 H-NMR spectra in CDCl
3
at 25 o C of a sample of P(MEO
8
MA-co-AcSEMA)-7 copolymer (black line), non-hydrolized QD@P(MEO
8
MA-co-AcSEMA)-7 hybrid (red line) and hydrolized P(MEO
8
MA-co-SEMA)-7 hybrid.
FIGURE S2 FTIR-ATR spectra of multidentate dyalized hybrids of QD@P(MEO
3
MA‐co‐AcSEMA)-
7.5 non-hydrolized sample (black line) and QD@P(MEO
2
MA-co-SEMA)-7,5 hydrolyzed one (red line).
2

FIGURE S3 SEC traces of all P(MEO n
MA-co-AcSEMA)-x synthetized copolymers determiner by
GPC in a mobile phase: dimethylformamide (DMF) with LiBr (0.1 wt %) at 0.3 mL min -1 and
70 o C with a differential refractometer detector. Poly(methyl methacrylate) (PMMA) standards were employed for the calibration.
FIGURE S4 TEM images of a) CdSe@P(MEO
2
MA-co-SEMA)-5 and b) CdSe@P(MEO
2
MA-co-
SEMA)-10 above LCST.
3

FIGURE S5 a) Fluorescence emission evolution with pH and temperature for
CdSe@P(MEO
2
MA-co-SEMA)-10 starting from QD of 4.06 nm of diameter. Data obtained in
front face mode.
4