2007 - 2012
Program Director/Principal Investigator (Last, First, Middle)
:
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on
Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Ramkumar Krishnamurthy eRA COMMONS USER NAME (credential, e.g., agency login)
POSITION TITLE
Medical Imaging Scientist/ Research Scientist
Texas Children’s Hospital
EDUCATION/TRAINING
INSTITUTION AND LOCATION
University of Madras, Tamilnadu, India
DEGREE
(if applicable)
BS
MM/YY
2002
FIELD OF STUDY
Electrical Engineering
University of Arizona, Tucson, AZ MS 2005 Electrical Engineering
Rice University, Houston, TX PhD 2013 Bioengineering
A.
Personal Statement
I am a senior research/imaging scientist (MRI) in the department of Pediatric Radiology at Texas Children’s Hospital. I am responsible for developing and optimizing MRI protocols for cardiac and body MRI studies. My research is focused on cardiac and body MRI imaging. My interests include studying MRI cardiac biomechanics, optimizing MRI protocols for children with congenital heart disease, adapting cardiac MR sequences to arrhythmia, adapting body MRI sequences to compensate for respiratory breathing, liver fat estimation (hepato-steatosis), and comparison of PET with MRI amongst others. I also serve as the
MRI safety officer in the department of Radiology and teach MRI physics to residents, fellows, and technologists.
B.
Positions and Employment
2013 – Present Sr. Research Scientist/ MRI Physicist, Texas Children’s Hospital, TX
2012 - 2013 Research Fellow, Department of Radiology, St. Luke’s Episcopal Hospital, Houston, TX
Graduate Research Assistant, Rice University & Department of Radiology, St. Luke’s Episcopal Hospital, Houston, TX
2002-2004 Graduate Research Assistant, University of Arizona
Publications
1.
Krishnamurthy R, Pednekar A, Atweh L, Krishnamurthy R, Muthupillai R. Clinical validation of free breathing respiratory triggered retrospectively cardiac gated cine balanced steady-state free precession cardiovascular magnetic resonance in sedated children. Journal of Cardiovascular Magnetic Resonance 2015, 17:1
2.
Krishnamurthy R, Muthupillai R, Cheong B., Review Article: Tools for cardiovascular magnetic resonance imaging.
Cardiovasc Diagn Ther 2014;4(2):104-125
3.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai Quantitative Evaluation of Regional RF shimming on a Wide
Aperture Dual-Channel Multi-Transmit 3.0T. R. Journal of Cardiovascular Magnetic Resonance 2013, 15:68 .
4.
Rivera E, Sethi R, Qu F, Krishnamurthy R, Muthupillai R, Swanson M, Eaton G, Wilson L. Nitroxide Radicals@
US‐Tubes: New Spin Labels for Biomedical Applications . Advanced Functional Materials. 22(17): 3691-3698
5.
Krishnamurthy R, A.Pednekar, B.Cheong, R.Muthupillai. High-Temporal-Resolution SSFP Cine MRI for Estimation of
Left Ventricular Diastolic Parameters. J Magn Reson Imaging. 2010 Apr;31(4):872-80
6.
Ananta JS, Godin B, Sethi R, Moriggi L, Liu X, Serda R, Krishnamurthy R, Muthupillai R, Bolskar R, Helm L, Ferrari M,
Wilson L and Decuzzi P Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast. Nature Nanotechnology, 2010 Nov;5(11):815-21
7.
Tran LA, Krishnamurthy R, Muthupillai R, Cabreira-Hansen Mda G, Willerson JT, Perin EC, Wilson LJGadonanotubes as magnetic nanolabels for stem cell detection.. Biomaterials. 2010 Dec; 31(36):9482-91
8.
Sathyanarayana P, Jogi M, Muthupillai R, Krishnamurthy R, Samson S and Bajaj M. Effects of Combined Exenatide and Pioglitazone Therapy on Hepatic Fat Content in Type 2 Diabetes. Obesity 2011; 19(12): 2310–2315
9.
Samson S.L., Sathyanarayana P., Krishnamurthy R., Muthupillai R., Bajaj M. Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.
Diabetology 2011; 54: 3093:3100.
PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle)
:
C.
Selected Conference Proceedings:
1.
Tomsa A, Bartz S, Krishnamurthy R, Krishnamurthy R, Bacha F. Endothelial Function in Youth Is Modulated By Adiposity-
Related Insulin Resistance and Inflammation. Endocrine Society 97 th annual meeting, March 2015, SanDiego
2.
Bartz, S, Caldas M, Smith W, Krishnamurthy R, Krishnamurthy R, Bacha F. Role of insulin resistance and hyperandrogenemia in early vascular dysfunction in adolescents with PCOS. . Endocrine Society 97 th annual meeting,
March 2015, SanDiego
3.
Krishnamurthy R, Noel C, Maskatia S, and Krishnamurthy R. Talk titled: Accurate Quantification of Cardiac Biomechanics in
Pediatric population: Respiratory Triggered High Temporal Resolution (RT-HTR) Myocardial Tagging in Cardiac MRI. Annual meeting of the Society of Pediatric Radiology, 2015.
4.
Sher A, Seghers V, Krishnamurthy R, Goette M, Lyons K, Krishnamurthy R. Talk titled: Comparison of Standardized Uptake
Values between PET/CT and PET/MR in Pediatric Lymphoma: A Prospective Study. Annual meeting of the Society of
Pediatric Radiology, 2015.
5.
Sher A, Seghers V, Krishnamurthy R, Goette M, Lyons K, Krishnamurthy R. Talk titled: Performance of PET/MR in the
Assessment of Pediatric Histiocytoses: A prospective study. Annual meeting of the Society of Pediatric Radiology, 2015.
6.
Sher A, Seghers V, Lyons K, Krishnamurthy R, Krishnamurthy R, Rohren E. Talk titled: Comparison of Lesion Detection and
Staging in Pediatric Lymphoma between PET/CT and PET/MR in a Tertiary Pediatric Hospital: A Prospective Study. Annual meeting of the Society of Pediatric Radiology, 2015
7.
Krishnamurthy R, Noel C, Pednekar A, Jacot J, Pignatelli R, and Krishnamurthy R. Poster titled: ‘Prospective Evaluation of
Circumferential and Longitudinal Strain in Asymptomatic Children with Dual Ventricles who underwent Single Ventricle repair: comparison to Single LV, Single RV and Normal Hearts’. Feb 2015, Nice, France- 18 th Annual Society of
Cardiovascular Magnetic Resonance Scientific Sessions.
8.
Noel C, Krishnamurthy R, Moffett B, Mckenzie E.D., Moodie D, Sexson –Tejtel S, Krishnamurthy R. Poster titled:
Regadenoson as a Pharmacologic Stressor in Cardiac Magnetic Resonance Imaging in Congenital and Acquired Pediatric
Heart Disease: Initial Experience. Feb 2015, Nice, France- 18 th Annual Society of Cardiovascular Magnetic Resonance
Scientific Sessions.
9.
Atweh L, Krishnamurthy R, Pednekar A, Lyons K, Krishnamurthy R. Poster titled: Comparison of Respiratory-Triggered (RT)
3D Cine Steady-State Free Precession Cardiac MRI with Standard 2D Cine Imaging and Magnetic Resonance Angiography in Congenital Heart Disease (CHD). Feb 2015, Nice, France- 18 th Annual Society of Cardiovascular Magnetic Resonance
Scientific Sessions.
10.
Krishnamurthy R, Seghers V, Paldino M. Talk titled: Quantitative Comparison of Attenuation Corrected FDG-PET Images
Acquired on Integrated PET/MR and PET/CT Systems: Validation of an MR-based Attenuation Correction Algorithm.
Annual meeting of the Society of Pediatric Radiology, 2014.
11.
Atweh L, Paldino M, Jones J, Mahmoud N, Williams J, Zhang W, Krishnamurthy R. Talk titled: MR Image Acquisition during the FDG Uptake Phase is Associated with an Increased Rate of False Positive Brain Examinations Performed on an
Integrated PET-MR Scanner. Annual meeting of the Society of Pediatric Radiology, 2014.
12.
Krishnamurthy R, Noel C, Pednekar A, Atweh LA, and Krishnamurthy R. Poster titled: Comparison of myocardial rotation and torsion in asymptomatic children with single RV, single LV and normal hearts. Journal of Cardiovascular Magnetic
Resonance 2014, 16(Suppl 1):P122
13.
Noel C, Krishnamurthy R, Pednekar A, David C, and Krishnamurthy R. Poster titled: Prospective comparison of circumferential and longitudinal strain in asymptomatic children with single left ventricle, single right ventricle and normal hearts. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):P111
14.
Krishnamurthy R, Cheong B, J. Smink, A.Pednekar and R.Muthupillai. Poster titled: Real-Time Prospective Adjustment of
Inversion Time using Arrhtythmia Insensitive Inversion Recovery Algorithm for Delayed Hyper-enhancement MRI Apr
2013, Salt Lake City, Utah - International Society of Magnetic Resonance in Medicine (ISMRM) 2013 Annual meeting.
15.
Krishnamurthy R, Cheong B, A.Pednekar and R.Muthupillai. Poster Titled: Quantitative Evaluation of Scar, Area at Risk, and Wall Thickening in a porcine model of sub-acute infarction. Feb 2013, San Francisco, California - 16 th Annual Society of Cardiovascular Magnetic Resonance Scientific Sessions.
16.
Krishnamurthy R, Pednekar A, Cheong B, Arena C, and Muthupillai R.E-poster titled ‘' Pitfalls of Using T
2
Weighted
Imaging for Visualizing Myocardial Infarction'’, May 2012, Melbourne, Australia- International Society of Magnetic
Resonance in Medicine (ISMRM) 2012 Annual meeting.
17.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R. E-poster titled ‘' Quantitative Evaluation of Regional RF shimming on a Wide Aperture Dual-Channel Multi-Transmit 3.0T: Implications for cardiac MRI'’,. May 2011, Montreal, Canada-
International Society of Magnetic Resonance in Medicine (ISMRM) 2011 Annual meeting.
18.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R.Poster Presentation titled ‘' Faster Inversion Recovery Prepared
T1 weighted segmented turbo field echo sequence (IR-TFE): Evaluating options for eliminating the start-up shot'’, R Feb
2011, Nice, France- 14 th Annual Society of Cardiovascular Magnetic Resonance Scientific Sessions
PHS 398/2590 Continuation Format Page

Program Director/Principal Investigator (Last, First, Middle)
:
19.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R. Oral Presentation titled ‘' Feasibility and validation of estimating
Globalfunctional indices from limited projections using a Modified Simpson’s Algorithm'’, Jan 2010, Phoenix, Arizona - 13 th
Annual Society of Cardiovascular Magnetic Resonance Scientific Sessions.
20.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R. Poster Titled ‘Arrhythmia insensitive inversion recovery preparation
(IR-prep)with real-time adaptive inversion delay (TI):Phantom validation, Jan 2010, Phoenix, Arizona - 13 th Annual Society of
Cardiovascular Magnetic Resonance Scientific Sessions.
21.
Muthupillai R, Arena C, Pednekar A, Krishnamurthy R, Flamm S. Oral Presentation titled ‘' Navigator guided high-resolution single-shot black-blood (BB) TSE images using zoom and sensitivity encoding (sense) on a 32 channel RF system'’, Jan 2010,
Phoenix, Arizona - 13 th Annual Society of Cardiovascular Magnetic Resonance Scientific Sessions
22.
Krishnamurthy R; Fischer J, Zurawin R, Dees D, Muthupillai R. Oral Presentation titled ‘Can Diffusion-weighted Magnetic
Resonance Imaging (DWI) Serve as the Non-contrast Alternative for Assessing Treatment Response of Uterine Fibroids and
Myometrium to Uterine Artery Embolization?’, November 2009; Radiological Society of North America (RSNA) 95th
Scientific Assembly and Annual Meeting.
23.
Krishnamurthy R, D Dees, M Jogi, V C Yagnik, R Muthupillai, M Bajaj. Oral Presentation titled ‘Noninvasive Quantitative
Evaluation of Hepatosteatosis in Response to Drug Treatment in Diabetic Population Using Magnetic Resonance
Spectroscopy (MRS) and Multi-Echo MR Imaging (MRI)’, November 2009; Radiological Society of North America (RSNA)
95th Scientific Assembly and Annual Meeting.
24.
Krishnamurthy R, Pednekar A, Cheong B, Muthupillai R Oral Presentation titled ‘Free Breathing and Breath-held High
Temporal Resolution (< 6 ms) Cardiac cine Steady State Free Precession (SSFP) imaging for Estimation of Diastolic
Function’, May 2008, Toronto – International Society of Magnetic Resonance in Medicine (ISMRM) 2008 Annual meeting.
D.
Honors:
 Magna Cum Laude – best poster presentation. International Society of Magnetic Resonance in Medicine (ISMRM) 2013 Annual meeting
 Graduate fellowship – Rice University
PHS 398/2590 Continuation Format Page