State Research Center of Russian Federation
Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
Obninsk Branch
Branch of Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
Address:
109 km, Kievskoye Shosse, Obninsk
Kaluga Region
Telephone: (48439)6-39-32, 7-47-50
Fax: (48439)6-39-11
E-mail: fci@KarpovIPC.ru
Location: 109 km south-west of Moscow
Area: more than 70 ha
Leading Center of radiation Chemistry in Russia
Branch of Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
Areas of scientific research and development:
- high-energy chemistry;
- radiochemistry;
- nuclear chemistry and physics;
- development of new radiopharmaceuticals;
- chemistry of high-molecular weight compounds;
- solid state physics;
- radiation-chemical technologies;
- radiation and space materials technology;
- neutron diffraction investigation and dynamics of different
class crystals.
Branch of Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
Up-to-date experimental and technological facilities,
including:
- nuclear reactor WWR-c;
- electron beam accelerators;
- powerful radionuclide sources of gamma radiation;
- wide range of technological facilities;
- testing and research units to investigate organic and
inorganic materials in the frames of radiation and space
materials technology projects;
- experimental-production shop.
Nuclear-chemical technologies
Branch of Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
•Leading producer and supplier of
radiopharmaceuticals and technetium-99m
generators in Russia.
•Karpov’s radionuclide and radiopharmaceutical
products are delivered to all Russian clinics.
•Development and production of
radiopharmaceuticals for diagnostics and therapy
are realized as an integrated production cycle
Nuclear reactor or cyclotronbased production of
radionuclides

Production of
radiopharmaceuticals
.
Recovery of
radionuclides
Generator
Synthesis of
carriermolecules
Clinic
Labeling
Preparation of
reagent kits
Preparation of
radiopharmac
euticals
Experimental and production facilities
Reactor WWR-c
Power – 10 MW
Fluence – 5× 1013 n/cm2·s
Number of experimental
channels – 31, including 9
horizontal
Number of hot cells – 9, each
handling 10000 g-equ. Ra
Number of heavy chemical
boxes - 5
Currently produced radiopharmaceuticals
Isotope
Chemical form
Application
Mo-99
T1/2=66.02 h
Sodium molybdate
Technetium-99m
Generator
Tc-99m
E=0.140 MeV
T1/2=6.01 h
Sodium pertechnetate
Technetium-99m
generator
Diagnostics with RIA kits
Iodine-131
E=0.365 MeV
T1/2=8.04 day
Sodium iodide in
isotonic solution
Thyroid gland, diagnostics and
therapy
Sodium iodide for
injections
Thyroid gland, diagnostics and
therapy
Sodium iodide in
capsules
Thyroid gland, diagnostics and
therapy
Ortho-Iodohippurate of
sodium
Kidney, diagnostics
Meta-Iodobenzyl
Guanidine
Adrenal, diagnostics
Samarium oxabiphor
Palliative therapy of skeleton
Samarium-153
Eβav.=0.233 MeV
T1/2=46.7 h
Currently produced radiopharmaceuticals
Isotope
Chemical form
Ferrum-59
E=1.2 MeV
T1/2=44.5 day
“Ferrum Sulphate, 59Fe 29kBq”
Carbon-14
Eβ av.=0.049 MeV
T1/2=5730 year
T1/2 bio=2.5 h
Urea-14C
“Ureacaps, 14C 37 kBq”
Application
Mammary gland,
diagnostics`
Diagnostics of
gastrointestinal
diseases: ulcer,
malignant tumours
Technetium-99m generator
GMP production line
for loading Tc-99m
generators is under
construction
The design makes it possible
- to decrease the number of
procedures, which ensure
operation condition of the
generator;
-to use light biological
shielding;
-to install a bactericide filter
to obtain aseptic eluate of
sodium pertechnetate.
Radiopharmaceuticals being developed
For diagnostics of myocardial
preinfarction condition
Diagnostics of myocardial
infarction
based on fat
phenylmethylpentadecanoic acid
labeled with 123I
99mTcN-DBODC5-heterocomplex
composed of PNP5 and
dithiocarbamate ligand
OCH3
H 3CO
C2H5O
CH
CH2
C
95
O
C
NH
CH
H3C
CH3
5
O
N
C
H 3CO
N
Tc
P
CH3
CH2
P
S
N
S
OC2H5
OC2H5
OCH3
O
CH2
HC
CH2
Thermoselfcollapsing
therapeutical radiopharmaceutica
OH O
DTPA(PhA)
X
Х = 153Sm, 188Re , 90Y,
117mSn
Items produced by radiation-chemical technology
Nuclear-doped semiconductor materials
(silicon, gallium arsenide, etc. for power
electronics)
Radiation-modified minerals (topazes, etc.)
Pilot projects:
– to
build up a facility for Technetium-99m generator loading in
accordance with GMP requirements;
– to build-up an up-to-date facility for radiochemical production
of radionuclides and radiopharmaceuticals (investment project
developed);
– to develop a technology and build up a facility for production of
alpha-emitters actinium-225 and radium-223;
– to launch molybdenum-99
uranium targets.
production
from
low-enriched
 RADIATION CHEMICAL TECHNOLOGIES
Radiation-chemical technologies developed by
Karpov Institute
curing of paint coatings on the surface of wooden, metallic and
gypsum products;
modification of rubber products (tires, etc. );
production of composite materials (binders and prepregs for
further manufacturing high-strength and heat-resistant
products);
modification of polyolefins (production of foamed
polyethylene materials and products, hot water supply and
heating pipes, gas distribution piping, heat –shrinkable tapes
for electric insulation);
sterilization of medical products, drugs, herbal raw material;
synthesis of polymer latexes for wall-paper and tanning
industry, gel production for perfumery and pharmaceuticals;
Radiation-chemical technologies developed by
Karpov Institute





monomer grafting onto polymer products (to obtain
adhesion-bonding surfaces and separation materials for
chemical current sources);
processing of minerals and microelectronic products (to
obtain marketable semi-precious stones and to increase
microchip characteristics);
destruction of Teflon;
radiation-chemical modification of Teflon;
production of porous filters (to purify water, air, fuel,
aggressive liquids)
Electron beam accelerators
Accelerator
Developed by
Basic technical characteristics
Energy, MeV
Power, kW
ЭЛВ-2
ИЯФ СО РАН
0,8 – 1,5
20
УЭВТ-0,5-20-Т-100-1
ИЯФ СО РАН
0,4 – 0,7
20
«Электроника У-003»
ЦНИИ
«Электроника»
4-8
5
ЭЛУ - 4
ЦНИИ
«Электроника»
3-5
5
«ЭЛЕКТРОН-3М»
НИИЭФА им.
Д.В.Ефремова
0,4 – 0,7
7
УЭЛР-10—10-Т-80
НИИЭФА им.
Д.В.Ефремова
8 - 10
10
Experimental and production facilities
УЭЛР-10-10-Т-80 in a trench
Locally-shielded
accelerator
“Electron-3M”
Technological facility for PE cross-linking.
Production of foamed polyethylene and heatshrinkable insulation tape.
Technical characteristics of Co-60
γ-facilities, total activity 1490 kCi
Сo-60 gamma Activity,
ray facility
kCi
Max
absorbed
doze,
rad/sec.
Irradiator
dimensions.
mm
Raise
time, sec.
KCB-500
650
550
Ø 90, h=125
180
PARKET
300
170
300 x100 x90
240
PX-gamma-30
(Researcher)
20
70
Ø 20, h=20
60
K-120, Build. KU
80
70
Ø 50, h=40
120
K-200
140
200
Ø 30, h=40
120
UGRA
100
250
Ø 30, h=30
0.5
VULKAN1
100
250
Ø 50, h=100
0.5
VULKAN2
100
250
0.5
Items produced by radiation-chemical technology
Products made from
foamed polyethylene
sheets
Items produced by radiation-chemical technology
Heat-resistant polyethylene pipes
Radiation-modified heat-shrinkable items
Items produced by radiation-chemical technology
Polyethylene filters
To purify:







drinking water,
beverages,
paints and resins,
photoemulsions,
water and reagents for microelectronics,
magnetic paint,
lubricants and cooling liquids.
Pore size, m
1 - 100
Total porosity, %
50-55
Efficiency of water purification from 1 m
particles, %
99.55
O
Tmax, C
100
Branch of Federal State Unitary Enterprise
«Karpov Institute of Physical Chemistry»
PILOT PROJECTS
- center of radiation sterilization and decontamination
of medical wastes;
specialized facility for radiation modification of
polytetrafluoroethylene
-