MARK BARTLETT, PHD
Vice President,
Global Research and
Development
Pharmanex
Our product development efforts and
investment enable us to CONTINUALLY
REFRESH the vibrancy of the business
opportunity through PRODUCT INNOVATION
Our anti-aging product strategy
is to leverage LEADING EDGE SCIENCE
to further understand the aging
process.
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Science in product development
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Discovery process
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Development process
Scientific assets
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Multiple unique tools to discover and
develop anti-aging products with meaningful
benefits
AGELOC GENE TECHNOLOGY
GENE EXPRESSION
IN YOUNG TISSUE
GENE EXPRESSION
IN OLD TISSUE
OLD GENE
EXPRESSION
AFTER AGELOC
Gene Expression Scale
Low
Expression
High
Expression
FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a preclinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and
old with ageLOC science (column 3). Each row represents one of 52 genes comprising the
mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes
became more or less active during the aging process. In column 3, the YGC activity pattern of
the old with ageLOC science group has been reset to a gene expression pattern similar to the
young group in column 1.1
1
Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon
Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27,
2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.
• Our Science, Your
guarantee
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6S Quality Process
Selection; Sourcing; Standardization;
Safety; Structure; Substantiation
Quality
Innovation
Safety
Substantiated claims
ANTI-AGING PRODUCT DEVELOPMENT PROCESS
ageLOC science
6S process
TOOLKIT
R&D ENGINE - PROVO INNOVATION CENTER
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R&D ENGINE CHINA INNOVATION PARK
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NEW ANTI-AGING AGELOC TOOLS
LifeGen
NOX Technologies
• Patented technologies to
study anti-aging
interventions through gene
expression science
• Acquired November 2011
• Patented anti-aging
technology
• Incorporated in ageLOC
Transformation and
Galvanic Gels
• Acquired November 2012
Healthy Aging
Nutrition
Science
Antioxidant
Science
Gene
Science
???
AGELOC GAMMA: WEIGHT
MANAGEMENT SYSTEM
Advanced ageLOC
Products
Simple Eating &
Lifestyle Plan
• AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene
expression science
• ageLOC Gamma helps you look slimmer and healthier in 90 days when
used in conjunction with a healthy diet and exercise
AGELOC GAMMA: INFLUENCING WEIGHT
• Key Tissues
– There are key tissues that address critical areas of weight
loss through gene expression. ageLOC Gamma will focus
on these key tissues
AGELOC GAMMA
AGELOC GAMMA: STUDIES
• LifeGen (gene expression science)
– Gene array analysis to elucidate YGCs
• Clinical Studies
– Open label study (ongoing)
– Larger trial (starting in 2013)
GAMMA SYSTEM
Incorporating ageLOC science and clinically
demonstrated ingredients
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AGELOC GAMMA REPRESENTS A
MAJOR INNOVATION WITH GENE
EXPRESSION SCIENCE
S3: SCANNER UPGRADE
COMING SUMMER 2013
• 25% smaller
• Wireless
• Battery operated
FUTURE PIPELINE
INNOVATIVE ageLOC SKIN CARE and NUTRITION
AGELOC INNOVATION PATTERN
2010
2013
2020