Histology Laboratories
Molecules to Systems
2003
Compiled by
James D. Jamieson, MD/PhD
Thomas L. Lentz, MD
No part of this image collection may be distributed outside of the
Yale University Intranet.
Acknowledgements
Sources of Micrographs, Diagrams and Figures
Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New
York, 2002.
Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins,
Baltimore, 1994.
Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.
Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning
electron microscopy. W. H. Freeman, San Francisco, 1979.
Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.
Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000.
Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.
Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill
Livingstone, Edinburgh, 2000.
Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson,
Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.
Web Resources
http://info.med.yale.edu/webpath/webpath.htm
Cushing Library Educational Software/Cell Biology/Several Histology Resources
Lymphoid System Laboratory
Plasma Cell
Germinal Center (GC)
Peyer’s Patches (Lymphoid Follicles) in Small Gut
Diffuse GALT in gut lamina propri
Organized GALT/MALT
GALT: gut-associated lymphoid tissue
MALT: mucosa-associated lymphoid
tissue
Lymphoid follicle
Germinal center
Peyer’s Patch
Afferent lymphatic
Subcapsular sinus
Cortex
Efferent lymphatics
Medullary cords
Hilus
Medulla
Lymph Node
Secondary follicles
Cortex
Medulla
Germinal centers
Lymph Node
Afferent lymphatic with valve (V)
Subcapsular sinus
Germinal center: B cell
proliferation and maturation
Secondary Follicle
Mantle of resting and
memory B cells
Reticulin stain of lymph node
Palatine tonsil
Cortex
Medulla
Thymus
Cortex (developing T
cells)
Medulla
Thymus
Thymic medulla with Hassall’s corpuscles
Hassall’s corpuscles
Development of T cells in Thymus
Spleen
White pulp
Red pulp
PALS
Trabeular artery
Spleen
B cell mantle
GC
Central arteriole
PALS (T cells)
Spleen
Venous sinus
Endothelial cells
Spleen Red Pulp
Direction of
blood flow in
spleen
Organization of the spleen
Some Pathology
Benign Reactive Lymph Node
Benign Reactive Lymph Node
Which cells are responding?
Adenocarcinoma Metastases to Lymph Node
How did the tumor cells get to this location?
Adenocarcinoma Metastases to Lymph Node
How did the tumor cells get to this location?