Rex Williams
Nhi Nguyen
Dr. Ryan Klein
Randhir Shetty
Dr. Dhiren Thakker
http://www.genome.gov/glossary/index.cfm?id=58
Lipase
NORMAL
LIPASE
Animation Courtesy of Dr. Ryan Klein
O
O
NH
N
O
O
O
ENHANCED
LIPASE
N
O
NH
O
O
N
O
NH
O
O
O
N
NH
Animation Courtesy of Dr. Ryan Klein
Dairy
Projected
Products, 2012 Global Lipase Market
17.39%
• Projected global lipase market
(2012)- $100 million
• Existing markets are stagnant
Detergent,
41.15%
Sweetners,
21.09%
• Current markets are dominated by a
small number of manufacturers
Leather,
6.28% Biofuels,
0.10%
Rationale For Biodiesel Application
Pulp &
Chemicals, Paper, 6.69%
7.30%
From BCC Research, 2007
• Rapidly growing industry (CAGR >20%)
• Lipases allow use of lower-cost feedstocks
“However, in order to compete with diesel fuel and survive in the market, lower-cost
feedstocks are preferred, including waste cooking oil (WCO), grease, soapstocks [3-18], since
feedstocks costs are about more than 85% of the total cost of biodiesel production”
-- Fan & Burton, The Open Fuels & Energy Science Journal, 2009
• Expected YOY consumption
growth rate in US is 20%
• Chinese commercial enzymatic
biodiesel production: 6 million
gallons/year pilot plant
U.S. Consumption of Biodiesel
Million gallons
• US 2010 biodiesel market size:
$3.2 Billion
800
600
400
200
0
2003
2004
2005
2006
2007
2008
2009
Year
Source: 2010 Euromonitor International
Current State of the Technology
• Reaction chemistry demonstrated in lab
• Lipase catalyzed process is emerging in biodiesel industry
• International patent filed: PCT/US2008/005486
• US patent applied filed: 12/597,821
2010
Next steps for Enhanced-Lipase Technology
MARKET PULL
QUANTIFICATION
TECHNOLOGY
DEVELOPMENT
CUSTOMER
VALIDATION
LICENSING / JV
• Quantify potential improvements in process efficiency
• Assess state of competing technologies addressing market
need
• Confirm proof of concept in small-scale biodiesel production
• Secure additional IP capturing value for biodiesel application
• Sense customer response to biocatalyst application with
different feedstock
• Perform quantitative product pricing study to establish
willingness to pay
• Perform cost-benefit analysis between JV & licensing
• Assess potential partners for commercial launch.
Coaches
• Anil Goyal, Ph.D., CLP
OpenDoors Group, LLC
BioLeap, Inc.
• Jay Madan
iBiotech, Inc.
Inventors/Advisors
• Dhiren Thakker, Ph.D.
UNC School of Pharmacy
Team
• Rex L. Williams, Jr.
UNC Department of Genetics
rwilliam@med.unc.edu
• Nhi Nguyen
UNC School of Law
npnguyen@email.unc.edu
• Randhir Shetty
UNC Kenan-Flagler Business School
Randhir_Shetty@kenan-flagler.unc.edu
• Ryan Klein, Ph.D.
Office of Technology and Development
• Peter Liao