Why Is Cancer Therapy Such a Difficult
and Often Intractable Effort?
Cancer Genome Landscapes.
Science, Vol. 339, March 29, 2013, pp 1546 – 1548
Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu,
Shibin Zhou, Luis Diaz, Kenneth W. Kinzler
Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer
Center, Baltimore
VogelsteinScience15Apr13.ppt
Updated: April 15, 2013
Number of
somatic
mutations
associated with
cancers in
patients
From 5 or 10 to
130 to 700
mutations per
tumor
(Insertions & deletions)
(Single base substitutions)
Signaling
Pathways
Affected
In Cancers
Pathway Anomalies in Progression in Colo-Rectal Cancer
The RAS Pathway
as a representative
signaling pathway
affected by cancer
mutations and
approaches to
therapy based on
RAS pathway
anomalies
RTK = receptor
tyrosine kinase