HORIZON 2020 HEALTH WORKSHOP
Presentation of project ideas for consortia
building
10th April 2014
Novara, Italy
Prof. Dr. Frank Rösl/Dr. Sabrina Vinzon
Department logo
SECTORS OF EXCELLENCE
Dept. Viral Transformation Mechanisms
German Cancer Research Center
Heidelberg, Germany
Sectors of excellence:
HPV-induced carcinogenesis
•
Gene regulation
•
Epigenetics
•
Metabolism
Innate Immunity
• Cytokine/Chemokine regulation
• Tumor microenvironment
Vaccine development
PROJECT DESCRIPTION
Description of the project (background)
Organ transplant recipients (OTR) frequently suffer from fulminant warts that
are induced by cutaneous human papillomaviruses (HPV). Moreover, some
skin HPV types may also be involved in the development of non-melanoma
skin cancer. Mimicking the situation of immunosuppressed OTR who acquire
cutaneous HPV infections already in childhood, we explored the efficacy of a
vaccine in infected animals that additionally underwent immunosuppression.
We demonstrate for the first time the success of a vaccine against a skin
papillomavirus in a natural outbred animal system, which completely
prevents both benign and malignant skin tumor formation even under
immunosuppressed conditions. Hence, our study provides the basis for
clinical development of a vaccine against cutaneous HPV infections, which
may be particularly useful in transplant recipients.
PROJECT DESCRIPTION
Description of future projects
Generation of a broadly protective (L2-based vaccine) that
prevents both cutaneous AND mucosal papillomavirus infections
Define factors that predispose to the development of nonmelanoma skin cancer
Type of cooperation
searched
TYPE OF PARTNER SEARCHED
Target partners searched
Partners working in basic research (T-cell immunologists)
Partners providing high-throughput platforms
Tasks to be performed of the partner sought
Providing tools to analyze T-cell responses
Transcriptome and Genome analysis
Finding SNPs that predispose to cancer development
http://www.dkfz.de/en/f030/index.php
THANK YOU!
f.roesl@dkfz.de
s.vinzon@dkfz.de