Vrijdag 20 maart 2015
Poster rounds DEGH meeting (including breakfast buffet)
Zaal 19
09.00 – 10.00
Chairs:
D. Jonkers and A.A. te Velde
1.
BMP4 signaling is involved in epithelial-mesenchymal transition in Barrett’s esophagus
and esophageal adenocarcinoma through induction of SNAIL2
C. Kestens1, P.D. Siersema1, J.W.P.M. van Baal1, 1Dept. of Gastroenterology and Hepatology,
University Medical Center Utrecht, Utrecht, The Netherlands
2.
Portal release of the bile salt homeostatic factor FGF19
K.V.K. Koelfat1, F.G. Schaap1, J.G. Bloemen1, P.L.M. Jansen1, C.H.C.
Damink1, 1Department of Surgery, Maastricht University Medical
School of Nutrition and Translational Research in Metabolism,
Maastricht, the Netherlands
3.
Inhibition of BMP2 and BMP4 by a novel llama-derived nanobody sustains intestinal
stem cells in organoid cultures
S. Calpe1, A. Correia1 , M. El Khattabi4, C.Zimberlin3, J.P. Medema3, C. T.Verrips4, K.K.
Krishnadath1,2*,1Center for Experimental & Molecular Medicine; 2Department of
Gastroenterology & Hepatology; 3Laboratory for Experimental Oncology and Radiobiology,
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4QVQ
BV, Utrecht, The Netherlands
4.
Dissecting crosstalk between hepatitis e virus infection and the 4e-bp1 translational
regulator
X. Zhou1, L. Xu1 , W. Wang1, K. Watashi2, Y. Wang1, D. Sprengers1, H.L.A. Janssen1, 3, P.E.
de Ruiter4, L.J.W. van der Laan4, J. Neyts5, H.J. Metselaar1, N. Kamar6,7,8, M.P.
Peppelenbosch1, and Q. Pan1*,1Department of Gastroenterology and Hepatology, Erasmus
MC-University Medical Center and Postgraduate School Molecular Medicine, Rotterdam,
Netherlands. 2Department of Virology II, National Institute of Infectious Diseases, 1-23-1
Toyama, Shinjuku-ku, 162-8640 Tokyo, Japan. 3Division of Gastroenterology, University
Health Network, Toronto, Canada. 4Department of Surgery, Erasmus MC-University Medical
Center and Postgraduate School Molecular Medicine, Rotterdam, Netherlands. 5Department
of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven,
Belgium, 6Department of Nephrology and Organ Transplantation, CHU Rangueil, France,
7INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France, 8Université Paul Sabatier,
Toulouse, France
5.
Barrett’s esophagus cell of origin does not derive from cytokeratin 5 expressing
squamous cells in mice
D. Straub1,2; N. Buttar3; P. Fockens1, K.K. Krishnadath1,2, 1Department of Gastroenterology
and Hepatology, Academic Medical Center, Amsterdam, Netherlands. 2Center for
Experimental and Molecular Medicine (CEMM), Amsterdam, Netherlands. 3Barrett
Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of
Medicine, Rochester, MN, USA.
by the human gut
Dejong1, S.W.M. Olde
Center and NUTRIM
Maastricht University,
Vrijdag 20 maart 2015
6.
Relating genetic variants in IBD to aberrant cytokine profiles: a focus on TNFSF15
N.W. Duijvis1, F.H. van Dooren1, D. Oudejans1, S.C. Wolfkamp2, S. Keskin1, E.W. Vogels1,
P. Henneman3, P.C. Stokkers4, G. D’Haens2, W. de Jonge1, A.A. te Velde1, 1Tytgat Institute
for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
2Dept. of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The
Netherlands. 3Department of Clinical Genetics, Academic Medical Center, Amsterdam, The
Netherlands. 4Dept. of Gastroenterology and Hepatology, Sint Lucas Andreas Ziekenhuis,
Amsterdam, the Netherlands
7.
Toll-like receptor 2 enhanced lysosomal activity and endocytosis in a Barrett’s
esophagus cell line
R.E. Verbeek1, P.D. Siersema1, F.P. Vleggaar1, F.J. ten Kate2, G. Posthuma3, R.F. Souza4, J. de
Haan1, J.W.P.M. van Baal1, 1Dept. of Gastroenterology and Hepatology, 2Dept. of Pathology,
3Dept. of Cell Biology, Center for Electron Microscopy, University Medical Center Utrecht,
Utrecht the Netherlands, 4Dept. of Medicine, University of Texas Southwestern Medical
Center, VA North Texas Health Care System, Dallas, Texas, USA
8.
IFN-free therapy for chronic HCV: transcriptomics and NK cell analyses
M. Spaan1, G. van Oord1 , K. Kreefft1, J. Hou1, B.E. Hansen1, H.L.A. Janssen1,2, R.J. de
Knegt1, A. Boonstra1, 1Department of Gastroenterology and Hepatology, 2Department of
Gastroenterology and Hepatology, University Health Network, Toronto Western Hospital,
Canada
9.
Human plasma toxicity in differentiated HepaRG progenitor cells the context of the
bioartificial liver
M. van Wenum* #, R.A.F.M. Chamuleau#, E.J. Hendriks*, T.M. van Gulik*, R. Hoekstra*#,
*Experimental Surgery, #Tytgat Institute for Liver and Intestinal Research, Academic Medical
Center, Amsterdam, the Netherlands
10.
Establishment of genetically stable canine liver organoids for translational studies
Schotanus1, Spee1, Nantasanti1, Kruitwagen1, Huch2, Vries2, Clevers2, Penning1, Rothuizen1,
1Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, the
Netherlands. 2Hubrecht Institution, Utrecht, the Netherlands
11.
Simple coculture system shows mutualism between anaerobic faecalibacteria and
epithelial Caco-2 cells
Sadaghian Sadabad M1, 2, Tanweer Khan M., Blokzijl T.3, Paglia G.4,5, Dijkstra G.2*, Harmsen
H.J.M1* and Faber KN2*. Departments of 1Medical Microbiology, 2Gastroenterology and
Hepatology, 3Laboratory Medicine, University of Groningen, University Medical Center
Groningen, Groningen, The Netherlands. 4Istituto Zooprofilattico Sperimentale di Puglia e
Basilicata, Foggia, Italy. 5Center for Systems Biology University of Iceland Reykjavik,
Iceland. *These authors contributed equally to this study.
12.
Mitochondrial Bio-genesis in the context of the AMC-Bio-Artificial Liver
'Adam A.A.A., ²Jongejan A., ²Moerland P.D., ³M.van Wenum, ³Van Gulik T.M., â´R.
Houtkooper, â´R. Wanders, Oude Elferink RP, 'Chamuleau R.A.F.M., ' ³Hoekstra R., 'Tytgat
Institute for Liver and Intestinal Research, ²Bioinformatics Laboratory, Department of Clinical
Epidemiology, Biostatistics and Bioinformatics, ³ Surgical Laboratory Academic Medical
Center, University of Amsterdam, the Netherlands, â•´AMC department of genetic and
metabolic diseases
Vrijdag 20 maart 2015
13.
Expression of the short-chain fatty acid receptors GPR41 and GPR43 throughout the
human ileum and colon
C. M. van der Beek1,2, K. Lenaerts1,2, M. van Avesaat1,3, F.J. Troost1,3, A.A.M. Masclee1,3,
C.H.C. Dejong1,2, 1Top Institute Food and Nutrition, Wageningen, the Netherlands,
2Department
of Surgery, and 3Department of Internal Medicine, Division of
Gastroenterology-Hepatology; NUTRIM School for Nutrition, Toxicology and Metabolism,
Maastricht University Medical Center, Maastricht, The Netherlands
Poster rounds DEGH meeting
Zaal 20
10.00 – 11.00
Chairs:
D. Jonkers en A.A. te Velde
1.
Modeling rotavirus infection and antiviral therapy using primary intestinal organoids
Y. Yin1, M. Bijvelds1, K. Knipping2, Y. Wang1, J. de Jonge3, N. Tuysuz4, D. ten Berge4, D.
Sprengers1, L.J.W. van der Laan3, H.J. Metselaar1, H. de Jonge1, M.P. Peppelenbosch1, Q.
Pan1, 1Department of Gastroenterology and Hepatology, Erasmus MC-University Medical
Center, Rotterdam. 2Nutricia Research Utrecht. 3Department of Surgery, Erasmus
MC-University Medical Center, Rotterdam. 4Department of Cell Biology,
Erasmus MC Stem Cell Institute, Erasmus MC-University Medical Center, Rotterdam
2.
Interaction of BDCA3+ dendritic cells with HBsAg specifically inhibits IFN-lambda
production
E. van der Aa1, P.J. Biesta1, F.A. Ayhan1, A. van den Bosch1, N. van Montfoort1, A.M.
Woltman1, 1Erasmus MC University Medical Center
3.
Tumor antigen expression in hepatocellular carcinoma in a low-endemic western
area
K. Sideras1, S. Bots1, K. Biermann‎2, D. Sprengers , W.G. Polak‎3, J.N.M. Ijzerman3, R.A. de
Man1, Q. Pan1, S. Sleijfer4, M.J. Bruno1, J. Kwekkeboom1, 1Erasmus Medisch Centrum,
afdeling Maag, Darm, en Leverziekten 2Erasmus Medisch Centrum, afdeling Pathologie
3Erasmus Medisch Centrum, afdeling Heelkunde Algemeen 4Erasmus Medisch Centrum,
afdeling Interne Oncologie
4.
The actual usage and quality of experimental colitis models in preclinical efficacy
testing
S.B. Zeeff1, C. Kunne1, A.A. te Velde1, 1Tytgat Institute for Liver and Intestinal Research,
Academic Medical Center, Amsterdam
5.
Stool proteomics reveals novel candidate biomarkers for colorectal cancer screening
A.C. Hiemstra1, S. Piersma2, T.V. Pham2, G. Oudgenoeg2, G.L. Scheffer1, S. Mongera1, M.A.
Komor1, J. Terhaar Sive Droste3, F.A. Oort3, S.T. van Turenhout3 , I. Ben Larbi3, C.J.J. Mulder3,
B. Carvalho1, R.J.A. Fijneman1, C.R. Jimenez2, G.A. Meijer1, 1Department of
Pathology, 2Medical Oncology, and 3Gastroenterology and Hepatology, VU University Medical
Center, Amsterdam, The Netherlands
Vrijdag 20 maart 2015
6.
Next generation sequencing of circulating miRNAs: towards predictive biomarkers
for celiac disease
I.L. Tan1, R. Almeida2, J. Di Tommaso1, S. Vriezinga3, Y. Li1, R.K. Weersma4, C. Wijmenga1,
M.L. Mearin3, S. Withoff1 on behalf of the PreventCD project group, 1Department of
Genetics, University of Groningen and University Medical Center Groningen, 2Department of
Genetics, Human Molecular Genetics Laboratory, Federal University of Paraná, Curitiba,
Paraná, Brazil, 3Department of Pediatric Gastroenterology, Leiden University and Leiden
University Medical Center, 4Department of Gastroenterology and Hepatology, University of
Groningen and University Medical Center Groningen
7.
Adult stem cell transplantation in a canine model for Wilsons disease
Spee B.1, Schotanus B.A.1, Kruitwagen H.S.1, Geijsen N.1,2, Penning L.C.1, Rothuizen J.1,
1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine,
Utrecht University, Utrecht, The Netherlands, 2Hubrecht Institute and University Medical
Center (UMC) Utrecht, Utrecht, The Netherlands
8.
Selective Janus Kinase 1 inhibitor targets monocytes and tissue macrophages during
DSS colitis
De Vries L.C.S.1,2, Duarte J.M.1, Hilbers F.W.M.1, De Winther M.4, Moerland P.D.5, Woodrow
M.D.3, Sims M.J.3, Ludbrook V.J.3, D’Haens G.R.A.M.2, De Jonge W.J.1,2 ,1Tytgat Institute for
Liver and Intestinal Research, AMC, Amsterdam, Netherlands, 2Department of Gastroenterology and Hepatology, AMC, Amsterdam, Netherlands, 3Kinase DPU, GlaxoSmithKline,
Stevenage, United Kingdom, 4Department of Medical Biochemistry, AMC, Amsterdam,
Netherlands, 5Department of Clinical Epidemiology, Biostatistics and Bioinformatics, AMC,
Amsterdam, The Netherlands
9.
Self-limited and acute to chronic HCV infections in at risk individuals result in phenotypically distinct NK cell compartments
R.A. de Groen1, G. van Oord1, Zwier M.A. Groothuismink1 , H.L.A. Janssen1,2, J. Schinkel3, and
A. Boonstra1,1Department of Gastroenterology and Hepatology, Erasmus MC, University
Medical Center Rotterdam, The Netherlands. 2Liver Clinic University Health Network,
Division of Gastroenterology, University of Toronto, Canada. 3Department of Medical
Microbiology, AMC, Amsterdam, The Netherlands
10.
Histone deacetylases in inflammatory mucosa distinguish Crohn’s disease from
ulcerative colitis
J. de Bruyn¹ ², R. Wichers³, T. Radstake³, J. Broen³, G. D’Haens¹,¹Academic Medical Center
Amsterdam, Department of Gastroenterology and Hepatology, ²Academic Medical Center
Amsterdam, Tytgat Institute for Liver and Intestinal Research, ³University Medical Center
Utrecht / Wilhelmina Children's Hospital, Department of Rheumatology & Clinical
Immunology
11.
PKC / AP-1 signaling drives transcription of interferon-stimulated genes and exerts
potent and broad antiviral activity
W. Wang1, W. Yijin1, X. Zhou1, Y. Yin1, L. Xu1, D. Sprengers1, H.J. Mason1, Y. Debing2, J.
Neyts2, M.P. Peppelenbosch1, and Q. Pan1*, 1Department of Gastroenterology and
Hepatology, Erasmus MC University Medical Center and Post Graduate School in Molecular
Medicine, Rotterdam, Netherlands, 2Department of Microbiology and Immunology, Rega
Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Vrijdag 20 maart 2015
12.
Impact of Vasopressin AVP1a Receptor Gene Polymorphisms on mortality and renal
failure in patients with acute decompensation of chronic liver disease
J.J. Schaapman1, J.C. Kerbert*1, J.J. van der Reijden1, A.A. Navarro2, M. Pavesi2, B. van Hoek1,
V. Arroyo3, M. Bernardi4, G. Soriano5, M. Catalina6, P. Aguilar7, H.W. Verspaget1, M.J.
Coenraad1, 1Gastroenterology- Hepatology, Leiden University Medical Center, Leiden,
Netherlands, 2Data Management Centre, CLIFconsortium, 3Gastroenterology-Hepatology,
University of Barcelona, Barcelona, Spain, 4Gastroenterology-Hepatology, University of
Bologna, Bologna, Italy, 5Gastroenterology, Hospital de la Santa Creu i Sant Pau,
Barcelona, 6
Gastroenterology
Hepatology,
Hospital
Gregorio
Maranon,
Madrid, 7Gastroenterology- Hepatology, Hospital Reina Sofia, Cordoba, Spain
13.
De novo nucleotide biosynthesis pathway tightly regulates hepatitis e virus infection
Y. Wang, W. Wang, X. Zhou, D. Sprengers, H.J. Metselaar, M.P. Peppelenbosch, and Q.
Pan, Department of Gastroenterology and Hepatology, Erasmus MC University Medical
Center and Post Graduate School in Molecular Medicine, Rotterdam, Netherlands.
11.00
Koffiepauze expositie