What is cancer?
@derka Я
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Otto Warburg
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Oxygen
deficiency
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Normal
oxygenation
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Oxygen
deficiency
Survival
by adaptation
to the new
environment
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Under the stressful conditions that
restrict growth and survival the
cells have to disobey part of the “nature rules”
in order to maintain nature’s drive for
1. Growth
2. Survival
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Disobey
restrictions
on growth
Oxygen
deficiency
Survival
by adaptation
to the new
environment
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Disobey
apoptotic
mechanisms
This is evolution by
adaptation to the
new conditions !
This is struggle for life of the cells !
They acquire genetic changes,
which help them survive the
unfavorable environment!
Heterocyclic amines
N-acetyl transferase
Heterocyclic amines
HIF-1
G-CSF
PDGF
VEGF
VEGF
VEGF
EGF-R
IGF-R GH-R
Erythropoietin-R
NGF-R
G-CSF-R
HGF-R
C-kit-R
Testosterone-R
Estrogen-R
Progesterone-R
Her 2
Human EGF Receptor 2
EGF-R
1
2
3
4
HER1/EGFR Dimerization
HER1 homodimer
HER1-HER1
Three HER1-containing heterodimers
HER1-HER2
HER1-HER3
HER1-HER4
Erythropoietin
NGF
Estrogen
Progesterone
G-CSF
EGF-R
IGF
HGF
P
P
P
P
Akt
ras
MAPK
ras
MAPK
Akt
P P
ras
MAPK
Akt
In order to survive:
Use any growth factor
available
Inhibit apoptotic
mechanisms
VEGF