Infrafrontier
The European infrastructure for phenotyping
and archiving of model mammalian genomes
Coordinator: Prof. Martin Hrabé de Angelis
Project Office: Dr. Michael Raess, Dr. Ana de Castro
Helmholtz Zentrum München
European Strategy Forum on
Research Infrastructures
www.infrafrontier.eu
ESFRI roadmap
First roadmap
in 2006
•
•
•
•
35
projects
BBMRI – biobanking
EATRIS – translational research
ECRIN – clinical trials
ELIXIR – bioinformatics
• Infrafrontier – animal disease models
• INSTRUCT – structural biology
Update in
Dec 2008
www.infrafrontier.eu
+ 10
projects
•
•
•
•
EU-OPENSCREEN – chemical biology
BLS4 – high security labs
Euro-BioImaging - bioimaging
EMBRC – marine biology
Grand Challenges
- Understand genetic and environmental impact
on human health
- Develop novel strategies for
diagnosis, prevention and therapies
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Why mouse?
• Mouse genome fully
sequenced
• 95% similarity of the
genes of mice and
men
• Easy to breed and
handle in captivity
• Extensive toolbox for
manipulating the
mouse genome
Current Biology
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Why mouse?
Publications on ‘Mouse Models’
Mouse models achieve high impact
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The challenge
Shortage on capacities and access:
Phenotyping (characterising mouse models)
• Mouse Clinics
EUMODIC, Infrafrontier
Archiving and Dissemination of mice and data
• Repositories
EMMA, Infrafrontier
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Required capacities
• Phenotyping
European Phenotyping Capacities
Mouse Lines / year
1750
1500
1250
1000
750
500
250
0
'00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
• Archiving and distribution
EMMA Requests (total)
EMMA Submissions (total)
7000
7000
6000
1500 p.a.
5000
4000
3000
2000
420 p.a.
1500 p.a.
5000
4000
3000
2000
350 p.a.
1000
1000
0
0
'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
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Mouse Lines
Mouse Lines
6000
'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
Infrafrontier: two main parts
Infrafrontier
Phenomefrontier
Archivefrontier
Archivefrontier/EMMA
Systemic
Phenotyping
Archiving /
Distribution
+ emerging centres
+ emerging centres
Access to phenotyping data and mouse models
Access to phenotyping services, data and mouse models
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Capacity building required!
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Osteogenesis imperfecta
A group of genetic bone disorders ...
Noted People with OI
• Jazz pianist Michel Petrucciani
• Actor writer and ethicist Peter Radke...
In the mouse model:
Bisphosphonate treatment
… reverses bone phenotype
… but does not lower mortality
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The German Mouse Clinic
Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009
www.mouseclinic.de
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Mouse model for Osteogenesis imperfecta
- Mutation in collagen I
Bone phenotype
•
Mineralisation defect
•
Bone deformity
•
fractures
•
Beaded ribs
•
Reduced Bone mineral content &
decreased bone mineral density
Systemic
•
Lung phenotype
•
Heart phenotype
•
Reduced fat mass & increased lean
mass
•
Metabolic alterations
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Infrafrontier partners
12 European Countries +
Canada
Research Institutions +
Funding Agencies
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Infrafrontier partners
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Smaller Project
Large Project
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Very large Project:
International Mouse Phenotyping
Consortium (IMPC)
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Infrafrontier and IMPC
Keep in mind:
• Infrafrontier is a BMS research infrastructure, NOT a single
project
• Infrafrontier has a different and broader portfolio than IMPC
(infrastructure for bottom-up and top-down projects)
• State of the art research infrastructures are highly dynamic
entities
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Infrafrontier preparatory phase
Official start:
36 months until:
01 March 2008
28 February 2011
4.5 Mio € funding by the European Commission
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Infrafrontier implementation
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Infrafrontier implementation
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Access to mouse resources and data
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Operation Costs
ES Cell Distribution
? € per line
User Fees
500 –700 €
Mouse Archiving
3,500 – 4,400 € per line
Mouse Distribution
1,100 – 2,100 € per line
User Fees
1,100 – 1,700 €
Cohort Breeding
23,000 – 30,000 € per line
Phenotyping
15,000 – 20,000 € per line
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User Fees
to be developed
New mouse clinics and EMMA nodes
Established facilities
New facilities
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Funding Strategy
Integration of national & European funds
National
infrastructure
funds
National and
European Projects
Technology Development
Operation
Personnel
Physical Infrastructure
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Decentralised funding model
European
Commission
Central
Coordination
MS
MS
MS
MS
MS
MS
MS = Member State
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Governance Infrafrontier ERIC (Boards)
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Governance Infrafrontier ERIC (Tasks)
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More Information ….
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Resource Sharing Policy
The Rome Agenda:
• “Funding organizations should … cover the costs of
deposition of materials arising from projects as part of the
project budget.”
• “Funding agencies should … ensure appropriate datasharing plans at the outset of projects …”
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More Information ….
Coordinator:
Prof. Dr. Martin Hrabé de Angelis
[email protected]
Project Office:
Dr. Michael Raess
Dr. Ana de Castro
[email protected]
Helmholtz Zentrum München
Institute of Experimental Genetics
Ingolstädter Landstrasse 1
85764 Neuherberg
www.infrafrontier.eu
Infrafrontier
The European infrastructure for phenotyping
and archiving of model mammalian genomes
Coordinator: Prof. Martin Hrabé de Angelis
Project Office: Dr. Michael Raess, Dr. Ana de Castro
Helmholtz Zentrum München
Scope of Activities
www.infrafrontier.eu
Constructing Required Capacities
EMMA Repository
Initial Investment (100 mouse lines):
~ 6,600,000 € for Construction
~ 2,000,000 € for Equipment
Adding capacities for 100 lines
~ 1,300,000 €
Mouse Clinics
Initial Investment (100 mouse lines):
~ 15,000,000 € for Construction
~ 5,000,000 € for Equipment
Adding capacities for 100 lines
~ 6,500,000 €
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Maintaining Capacities
EMMA Repository
Cryo-Archive (100 mouse lines):
~ 10,000 € per year
Maintaining and Updating Equipment
~ 10% of Purchasing Price per year
Mouse Clinics
Maintaining and Updating Equipment
~ 20% of Purchasing Price per year
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Infrafrontier project – key objectives
• Preparation to meet increasing demands for
phenotyping and archiving – capacity building
• Developing a business plan based on a
sustainable funding concept
• Identification of the most suitable legal form
• Providing a strategic plan for the construction
phase
• Reaching a legal agreement between all partners
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Key deliverables
• WP2 – Strategy and Governance
• WP3 – Legal Work
• WP4 – Financial Work & Funding
Implementation
Preparatory Phase
2008
2009
Draft Strategic Plan
WP2

2010
Update

WP4 Finance
WP3 Legal Work
Strategic Plan
 Business Plan

Legal status
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2011
MoU