NanoRelease Food Additive
Supporting Methods to Measure Food Nanomaterials
Webinar to present Task Group White Papers
April 16 , 2013
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What is the issue being addressed?
Nanopowder
Dissolved
constituents (no
longer nano?)
Engineered nanomaterials (ENM) used/being
developed for food, beverages, supplements
to:
- increase nutrition
- increase food safety (packaging, shelf life)
- change physical/chemical properties
Some “traditional” processed food components
are nano too. Where do we focus the science
to address potential risk?
Methods to measure what nano characteristics
affect absorption as nanoparticles into the
body would greatly clarify where to focus
attention.
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About the project
• 70+ multi-stakeholder experts collaborating for methods
development for oral exposure to ENM
• GOAL: Develop methods that distinguish which nanomaterials
do and do not persist to absorption from food.
 thus provide data that help clarify risk
 thus allow safer, sustainable improvements
OFFICIAL CHARGE: “Identify, evaluate, and develop
methods needed to confidently detect, characterize and
evaluate intentionally produced nanoparticles released
from food along the alimentary tract, as occurring through
direct food additives or indirect incorporation in food
through migration from food contact materials or
environmental contamination.”
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Benefits of the project
• Continuous technical dialogue internationally
across key stakeholder experts about safe
development of food nanotech
• Public-private partnership allows balance of
views from academia, industry, government,
public interest organizations
• Secretariat (ILSI Research Foundation) facilitates
collaboration without backing any particular
stakeholder view.
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Organization within project
TG1 Material
Characteristics
Develop charges and
decide scope (e.g., what
methods to improve)
Steering
Committee
(SC)
Collect and analyze
information relevant to
methods development
TG2 Alimentary
Canal
Environment
TG3 Alimentary
Canal Models
TG4
Measurement
Methods
TG5 Risk
Management
Aspects
Top level view of the
state of the science
and context.
State of the
Science Team
(SOST)
Develop and
implement workplans
to improve methods.
Interlaboratory
Testing Group
(ITG)
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Steering Committee
• COCHAIR Annette McCarthy (US
FDA)
• COCHAIR Steve Roberts (Univ. of
Florida)
• Timothy Duncan, Scott Thurmond,
Gregory Noonan (FDA)
• Thomas Neltner (Pew Charitable
Trusts)
• Andrew Maynard (Univ. of
Michigan)
• Joseph Scimeca (Cargill, ILSI NA)
• David Carlander (Nanotechnology
Industries Association)
• Francois Rossi (European
Commission)
• Stephane Vidry, Alessandro
Chiodini (ILSI Europe)
• Danielle Fugere (As You Sow)
• Robert Brackett (Institute for Food
Safety & Health)
• Shaun Clancy (Evonik Degussa)
• Carolyn Cairns, Michael Hansen
(Consumers Union)
• Neil Buck (DSM, ILSI Europe)
• Stefan Weigel (RIKILT – Institute of
Food Safety)
• Abdul Afghan, Don Forsyth, Andrew
Atkinson, David Lefebvre, Mark
Perry, Rekha Mehta (Health
Canada)
• Rickey Yada (Univ of Guelph)
• Vicki Stone (Heriot Watt Univ.)
• Eva Maria Collnot (Saarland Univ.)
• John Milner (USDA)
• Susann Bellman (TNO Netherlands)
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Jan-May 2012
SC gathered, establishes goal,
scope, & focuses of TGs
June-Sept 2012
TGs gathered, finalize charges,
collect and evaluate info
Sept 2012 - Now
TGs draft and finalize white
papers. SOST gathered, follows TG
progress & drafts review article
Mid 2013
TGs & SOST submit for publication,
ITG & SC review information and
decide on workplan(s)
2013-2014
Methods development
(interlaboratory round robin)
TIMELINE
Sept 2012
PROJECT
WEBINAR
Dec 2012
WORKSHOP
Washington, DC
Jan 2013
SOST
MEETING
Miami, FL
April
2013
PROJECT
WEBINAR
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SOST
State of the Science Team is an experienced, balanced multistakeholder set of experts who are writing a “state of the science”
report on: What do we know and need to know to measure and
understand the likelihood of nanomaterial uptake by the body?
Andrew Bartholomaeus
Christopher Szakal
U. of Canberra & U. of
Queensland
US National Inst. of Standards &
Technology
Ian Illuminato
Friends of Earth
John Milner
Human Nutrition Research Ctr.
(USDA)
Michael Rogers
Rutgers University
Neil Buck
DSM Nutritional Products
Paul Westerhoff
Arizona State University
Steve Roberts
University of Florida
Andrew Cockburn (peer review)
University of Newcastle
Paul Howard (peer review)
US Food and Drug Admin.
ITG
INTERLABORATORY
TESTING GROUP
• Lab research experts currently being gathered
• OBJECTIVE: Develop or investigate standardization of existing methodologies
(adaptation and validation) with any necessary modifications
• Interlaboratory work plans will improve/develop methods for understanding
uptake, using (-) and (+) controls and selected ENM in modeled GI conditions
• ULTIMATE GOAL: promote standardization or scientific consensus on practical
methods for evaluating potential uptake of ENM from alimentary canal
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Goal for this webinar
• Present high point findings of
the task groups
• Inform the State of the Science
team as they prepare their
summary
• Seek input from stakeholders
• Inform the Steering Committee
as they select methods to carry
forward
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Suggested topics for feedback
Please note that the project goal is to
GOAL: Develop methods that distinguish which nanomaterials do
and do not persist to absorption from food.
 thus provide data that help clarify risk
 thus allow safer, sustainable improvements
For example, please help us inform the Steering Committee in their
task to
- Cover what needs to be covered to prepare to address this goal
- Narrow scope to practical and near-term methods improvement
- Select methods improvements to address
- Identify how to improve the methods
- Identify synergies and partnerships
Thank you
Richard Canady, PhD
Libby Tsytsikova, BS
Secretariat for
nanorelease@ilsi.org
Center for Risk Science Innovation and Application (RSIA)
ILSI Research Foundation
1156 Fifteenth ST. NW, Suite 200
Washington DC 20005-1743
Tel: +1-202-659-3306 ext153
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