Skin Pigmentation
 Melanin in the Melanocyte Cells
 Eumelanin Black/Brown Pigment
 Pheomelanin Red/Yellow Pigment
 Response to UV Radiation
 Pigmented Cells
Resistant to Damage by Sun
Protected From Melanin Antioxidants
 Unpigmented Cells
Sensitive to Sunlight Damage
Protected by Glutathione/Selenomethionine
Antioxidants
DEPIGMENTATION Properties
of Glutathione/Selenium
•
Protect Skin from UV Radiation which generate free
radicals that cause skin damage and hyperpigmentation
•
GSH redirects synthesis to the light (Pheomelanin)
instead of the dark (Eumelanin)
•
Inhibits enzyme tyrosinase that synthesizes dark melanins
•
Skin Cell’s become more resistant to UV exposure
(Brigarti, 2003)
(Burke, 1997)
Skin Brightening
Thione Complex™ lozenges with:
 Glutathione & Selenomethionine
 Plus Antioxidant Vitamins C & E
 And the Glutathione Depigmenting Enzymes
 A complement to the Skin Brightening Products
 Free Radical Scavenging Functions to Reduce UV
Radiation to the Skin
 Works From Within To The Skin®
Melasma
 Blotchy Hyper-pigmentation of Face
 Associated with Pregnancy
 Topical Therapy
 Hydroquinone,
 Retinoic Acid
 Thione Complex™
 Oral Therapy with Glutathione/Selenium
 Reduces UV Radiation Impact on Affected Skin
 Induces Glutathione Enzymes
 Promotes Synthesis of Clear Melanin
 Inhibits Tyrosinase Enzyme that Makes Dark Melanin
The Aging Skin
 Chrono-aging
 Sagging Skin
 Photo-aging
 Wrinkles and Pigmented Lesions
 Ultraviolet Radiation
 Acute: Sunburn
 Chronic: Oxidative Damage
 Pre-malignant Lesions
(Keratosis, Moles)
 Malignancy
Squamous/Basal Cells
Malignant Melanoma
Influence of Glutathione Levels in
Melanin Synthesis
 Pathways to Melanin Synthesis
High GSH
↓
Low GSH

Eumelanin
(Dark Pigment)
Eumelanin
(Dark Pigment)
Conclusion:

High GSH levels influence pathway toward the production of greater
amounts of clear pigment (Pheomelanin) in skin cells