THE STORY OF
HYALURONAN AND
SYNO-VITAL
THE VILLAGE OF
YUZURIHARA
In 2000, an ABC TV news reporter visited the
Japanese village of Yuzurihara.
After conducting a survey of 990 villages, it was found
that there were 10 times more people over the age of
85 living in Yuzurihara than in the of North America and
Japan combined.
What’s more, the appearance of these people seemed
to defy the hands of time.
You can see that
original ABC News
report here:
http://www.youtube
.com/watch?v=Wh
gM34f7v9k
YOUTHFUL APPEARANCE
THANKS TO HYALURONAN
The Yuzurihara villagers had smooth skin, flexible
joints, think hair and good eyesight despite their
significant years.
On female resident in particular had skin that was free
from wrinkles and age spots despite being 90 years
old.
The local doctor with 60 years experience, Dr
Toyosuke Komori also noted there had never been a
case of skin cancer within the population, and there
were minimal incidences of other age related health
problems like diabetes and heart disease.
Dr Komori
attributes the
longevity and good
health of the
Yuzurihara
residents to a
substance called
HYALURONAN
(HA)
WHAT IS HYALURONAN
(HA, HYALURONIC ACID)?
First discovered in
1934, HA is the
principle compound in
the body used for
retaining moisture in
the connective
tissues and organs.
Hyaluronan is a glycosamineoglycan. It consists of two
sugar like molecules: glucosamine and glucuronic acid.
As the body is
between 55% and
78% water and
hyaluronan is
responsible for
maintaining this level
of water in the body, it
is an extremely
important molecule.
WHAT IS HYALURONAN
(HA, HYALURONIC ACID)?
HA occurs naturally in the body and is found in it
highest concentrations in collagen, which is the
substance found around cells.
It is HA’s ability to maintain hydration that supports
collagen and prevents it from cracking, drying and
degrading.
As we age, this collagen or connective tissue, loosing
it’s water content and dries out and this is when the
sign of aging, like wrinkles appear.
WHERE IS HYLAURONAN
IN THE BODY?
Hyaluronan can be
found in:
The human eye is
80% hyaluronan.
The Hair
The Eyes
The Skin
The Muscles
The Gums
The Joints
Blood and
Lymph Fluids
The skin is 56%
hyaluronan.
The muscles and
skeleton are 35%
hyaluronan.
The blood and
nymph fluids are
9% hyaluronan.
HYALURONAN AND SKIN
CARE
Over half the HA in the body is in the skin, which is the
body’s largest organ and is regularly renewed more
than any other kind of tissue.
Skin is heavily affected by lifestyle, in particular by
smoking, eating a poor diet and exposing it to sunlight.
The skin looses HA naturally as we age and so skin
becomes unable to retain as much water, leading to
the signs of aging.
Taking oral HA and using HA serums can help
replenish the skin and increase hydration in the
dermis.
HYALURONAN AND JOINT
SUPPORT
Hyaluronan is also found in the synovial fluid found
between joints and increases the viscosity of this fluid.
Osteoarthritis (OA) is the most common type of arthritis
affecting 1 in 13 people.
OA is a result of free radicals attacking the synovial
fluid in the joints, degrading it and reducing the
lubrication it provides between connecting bones.
This causes friction at the joint, especially on weight
bearing joints and so the symptoms and effects of
arthritis begin to manifest themselves.
Adding HA to the
joints can reduce
this friction and
provide a ‘cushion’
between the joints.
In synovial fluid HA
also acts as an
anti-oxidant and a
natural
inflammatory agent
helping relieve the
symptoms of
arthritis.
HYALURONAN AND
WOUND HEALING
HA production naturally increases during wound
healing processes.
The initial increase in HA production for would healing
is rapid and lasts for around 3 days, by day 7 the extra
hyaluronan has gone.
Ha is also known for blood vessel building properties
and it is through the blood vessels that nutrients
necessary for wound healing are transported to
damaged tissue, further explaining the importance of
HA for these processes.
In adults, wounds
do heal but can
result in scarring,
so by treating your
skin to extra HA by
using things like
HA serums, you
may be able to
reduce the
appearance of
wrinkles.
HYALURONAN (HA) AND
EYE HEALTH
Evidence suggests that a lack of HA in the eye can
lead to numerous age related eye disorders, for
example: people with Glaucoma have 77% less HA
than the levels found in normal eyes.
HA plays a role in
maintaining the
health of the cornea,
retina and vitreous
gel in the eyes.
Healthy vitreous gel is composed of 92% HA and 8%
Chrondroitin Sulphate. As HA levels deplete with time,
this can lead to a break down in the structure of the
vitreous gel leading to the formation of protein clumps
which can affect light travelling through the eye.
Its also an excellent
lubricant for contact
lens wearers.
Other research also shows that taking oral HA can
lower the risks of developing a detached retina or
suffering macular degeneration, a leading cause of
blindness in adults.
Taking HA improves
eye tissues and
health by raising HA
levels and,
strengthening
collagen structure
improving the visual
system.
CLINICAL STUDIES ON
HYALURONAN
There are many Hyaluronic Acid products available
now on the market. A review from the Journal of
Applied Nutrition examines the different kinds of HA
available and talks about their effectiveness.
Not all Hyaluronic Acid is created equal.
Keep in mind when reading this study that our
patented Syno-vital® is high molecular weight HA in
the 2.4-3 million Daltons!
Read the full study
in the Journal of
Applied Nutrition
here:
http://www.hyalogic
.com/hapopups/H
MW%20HA.pdf
CLINICAL STUDIES ON
HYALURONAN
"..dietary supplements containing HA are not
equivalent due to the inherent properties of the three
major types of HA commercially available as dietary
supplement materials. Consumers and health care
professionals need to be aware of the different types of
HA and their very large differences in properties (even
before ingestion). One source, hydrolysed chicken
sternal cartilage, is clearly unlike native HA, does not
match the biological properties of native HA, and
consequently should not be represented as HA to
consumers on product labels..."
CLINICAL STUDIES ON
HYALURONAN
ORAL ABSORPTION STUDY Washington. D.C., April 18, 2004
A consortium of scientists released clinical research
results about oral delivery of HA and its ability to be
taken up by joints.
Hyaluronan has been used for years in veterinary and
human medicine as an injection to replace lost joint
fluid.
The study was led by Dr. Schauss and conducted by a consortium of scientists
from the Life Sciences Division of the American Institute for Biosocial and Medical
Research Inc. in Puyallup, Washington and the National “FJC” Research Institute
for Radiobiology and Radiohygiene, National Institute for Health in Budapest,
Hungary. The research was supported by Weider Nutrition International.
Proven bioavability
and absorption
with High
Molecular Weight
HA
CLINICAL STUDIES ON
HYALURONAN
Until now, there was no data on pharmacokinetics after
oral intake and the therapeutic use of hyaluronic acid
was limited to injections or topical applications.
The results of this study, which examined the
absorption, excretion and distribution of radiolabeled
HA after a single oral administration in Wistar rats and
Beagle dogs, demonstrated that HA is absorbed and
distributed to organs and joints after a single oral
administration.
Excerpt from
Abstract # 129.4Absorption,
distribution and
excretion of
99mtechnetium
labelled hyaluronan
after single oral
doses in rats and
beagle dogs
CLINICAL STUDIES ON
HYALURONAN
High Molecular Weight HA from bacterial fermentation
was radioactively labelled with 99-technetium and its
oral uptake in rats and dogs was studied.
Uptake of HA into the bloodstream (5% of an oral
dose) was found, and scintigraphy found uptake of
labelled HA into joints
(FASEB, 2004). A. G. Schauss, L. G. Balogh, A. G. Polyak, D. G. Mathe, R. G. Kiraly and G. G.
Janoki American Institute for Biosocial and Medical Research, Inc and National Institute for Health.
Thus, purified, high molecular weight HA is
bioavailable and delivered to joints.
Approximately 4.5
billion molecules of
HA may reach
each knee joint
after oral ingestion
of 3 mg of HA in
humans. These
results
demonstrate that
HA is absorbed
and distributed to
organs and joints
after a single oral
administration.
An abstract with complete research
details was published in the April
issue of FASEB Journal
CLINICAL STUDIES ON
HYALURONAN
Most recently, hyaluronan has been implicated as a
factor in preventing cancer based on investigations
using naked mole rats.
Researchers found that the hairless rodent’s tissues
were rich in high molecular weight hyaluronan, which is
linked to tissue repair.
Experiments show that when HMW-HA is removed
from the creature’s cells, they become susceptible to
cancer, suggesting it plays a role in making the rodent
‘cancer-proof’
Read the full article
from Metro UK on
how the Naked
Mole-Rat may hold
the clue to beating
cancer here:
http://metro.co.uk/2
013/06/19/nakedmole-rat-may-holdthe-clue-tobeating-cancer3848778/
SYNO-VITAL FROM
MODERN HERBALS
The HA in Syno-vital
is great for athletes. It
works in several
ways:
Restores normal
synovial fluid with
improved viscoelasticity
Positively effects
biosynthesis and
degradation
Has anti-inflammatory
effects and is a direct
analgesic.
HYDRA-VITAL FROM
MODERN HERBALS
Hydra-Vital from Modern Herbals is a professional
strength Hyaluronic Acid (Hyaluronan) Serum designed
to help the skin gain and retain moisture.
See more at: http://www.modernherbals.com/vitaminsand-minerals/206-hydra-vital---purehyaluronan.html#sthash.wQT6lns1.dpuf
Natural extract of roses and Hyaluronan, makes this
Facial Spray very refreshing and stimulating.
See more at: http://www.modernherbals.com/761reviva-rosewater-facial-spray236ml.html#sthash.NALnFug0.dpuf
HYALURONAN: DID YOU
KNOW…
Newborn babies have high levels of hyaluronan in their
skin and it’s thanks to this that they do not develop
scars from cuts or scraps and why they have soft,
plump skin.
Just 1mg of
Hyaluronan can
hold 1,000 times
it’s weight in water.
Echinacea, the purple cone flower, is a herb that helps
maintain HA in the human body and therefore prevents
the spread of infection.
Human skin is 72%
water and the loss
of between just 24% of the body’s
water can lead to
dryness and
wrinkling.
HA shortens the time it takes wounds to heal by 50%
and can even help reduce thick, red keloid scars.
READ MORE…
For more information on the properties of hyaluronan
visit our custom built information site at
www.hyaluronan.eu