Bio-Xplore Final Conference
December 4th, 2014
Hadassah Academic College
Jerusalem Israel
BIO-XPLORE MISSION
 Utilize financial and human resources to discover, develop and
commercialize health and wellness products derived from
Mediterranean plants
 Promote human health based on scientific knowledge
 Impact academic education
 Stimulate regional economic development and communication
 Create an active collaboration among partners
Bio-Xplore Vision
 Contribute to regional economic development and
social well being
 Making Bio-Xplore Partnership the conduit for
bringing people together from different cultures,
religions and regions
 Using science to communicate and create trust
THE MAIN OBJECTIVES
Establish a strong and integrative working
team based on mutual trust and
complementary skills and resources
Train people in all partners areas in the
screening and discovery of plant
derived bioactives
Develop new screening assays according to
the directions of the Global Institute of Bio
Exploration (GIBEX)
WEB SITE
New screens developed
1.
2.
3.
4.
Anti viral assay
Anti cancer assay
Acethylcholine esterase inhibition assay
Modified Glucosidase and Glucosidase inhibition
assay
5. Anti cellulite assay: Phosphodiesterase inhibitor
Peer-reviewed publications
Gili Joseph, Mina Faran, Ilya Raskin, Mary Ann Lila and Bertold Fridlender Medicinal Plants of Israel: A Model
Approach to Enable an Efficient, Extensive, and Comprehensive Field Survey.. J Biodivers Biopros Dev 2014, 1:3
Sigal Matza-Porges, Kobi Eisen, Hadeel Ibrahim, Adva Haberman,Bertold Fridlender,Gili Joseph. A new antiviral
screening method that simultaneously detects viralreplication, cell viability, and cell toxicity. Journal of
Virological Methods 208 (2014) 138–143
Ibrahim M. Abu-Reidah, Mohammed S. Ali-Shtayeh , Rana M. Jamous David Arr‫ב‬ez-Rom‫ב‬n, Antonio SeguraCarretero HPLC–DAD–ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits
Food Chemistry 166 (2015) 179–191
Ahmad Ibrahim HuseinMohammed Saleem Ali-Shtayeh, Waheed Jebril Jondi, Nidal Abd-Aljapar Zatar, Ibrahim M.
Abu-Reidah, and Rana M. Jamous. In vitro antioxidant and antitumor activities of six selected plants used in the
Traditional Arabic Palestinian herbal medicine. Pharm Biol, Early ( 2014): 1–7
Mohammed Saleem Ali-Shtayeh1 Rana Majed Jamous1, Salam Yousef Abu Zaitoun1, and Iman Basem Qasem1 Invitro screening of acetylcholinesterase inhibitory activity of extracts from Palestinian indigenous flora in relation
to the treatment of Alzheimer’s disease.
Functional Foods in Health and Disease 2014; 4(9):381-400
Peer-reviewed publications
Abu- Reidah, I. M., Jamous, R.M., Ali-Shtayeh, M. S., (2014) Phytochemistry, pharmacological properties and
Industrial application of Rhus coriaria l. ( Sumac): A review. Jordan Journal of Biological Sciences (JJBS). 12/2014;
7(4):233 - 244.
Husein, A.I., Ali-Shtayeh, M. S., Jamous, R.M., Abu Zaitun, S.Y., Jondi, W.I., Zatar, N.,(2014) antimicrobial activities of
six plants used in traditional Arabic Palestinian Herbal medicine. African Journal of Microbiology Research
01/2014; 8(38):3501-3507.
Husein, A.I., Ali-Shtayeh, M. S., Jamous, R.M., Jondi, W.I., Zatar, N.,(2014). Phthalate derivatives are naturally
occurring in Arum palaestinum. International Journal of Current Research and Academic Review. 01/2014; 2(9):195203.
Ali-Shtayeh, M. S., Jamous, R.M., Abu-Zeitun S.Y.,(2014). Berc 2014 “National 2014 “ National list of Medicinal plants
in Palestine-west Bank and Gaza Strip”. 01/2014; Biodiversity and Evironmental Research Center
What was done in the Bio-Xplore project
All partners sampled and extracted 1000 samples or more.
All partners performed all 10 assays on all samples.
All partners continued the screening by using the dose response
method for the samples that scored the highest activity ( score 3).
3 partners (Leitat, BERC and Hadassah) developed new screens.
9 manuscripts were published in peer reviewed journals
2 articles were published in Israeli journals (in Hebrew) and 1 article
in Spain (in Spanish).
What are we delivering!!!
 Identification of plants with commercial potential
 Increased employment and business opportunity in the
agriculture, food, cosmetics and biotech industry
 Cross Border interaction among partners
 Increased awareness of the local public population to the
value of their natural flora
 Improved scientific and industrial knowledge of the
institutions involved
Thank you for being
here!