Does GRACE predict late mortality?
•
To define long term outcome in patients with
ACS and to test that GRACE risk score predicts
mortality and death/MI at 5 years.
METHODS
•
Prospective long-term study (median of 5 years)
in GRACE cohort in UK and Belgian centers
POPULATION
•
3721 patients with ACS ( STEMI, non-STEMI, UA)
•
Primary events: deaths, cardiovascular
deaths (CVDs) and MIs
Secondary events: stroke and rehospitalization
AIM
OUTCOMES
•
Fox KAA et al. Eur Heart J. 2010;31:2755-2764.
Late mortality across ACS is high
5-Year total cardiovascular death
5-Year total no. deaths
%
25
20
15
22
19
18
13
14
11
10
5
0
STEMI
non-STEMI
UA
Fox KAA et al. Eur Heart J. 2010;31:2755-2764.
GRACE strongly predicts long-term
outcome
%
100
75
50
25
Cox proportional hazard: P<0.0001
Fox KAA et al. Eur Heart J. 2010;31:2755-2764.
Conclusion
•The GRACE risk score is a valid and
powerful predictor of short- and longterm mortality of current patients with
ACS.
•The
risk
stratification
is
of
utmost
importance in improving clinical care and
long-term outcomes in patients with ACS.
Fox KAA et al. Eur Heart J. 2010;31:2755-2764.