Labile or stable: opposing consequences for
memory when reactivated during waking
and sleep
Susanne Diekelmann, Christian Büchel, Jan Born & Björn Rasch
Feng Jingyu
Memory Consolidation
Consolidation is defined as a time-dependent stabilization process that
leads eventually to the permanent storage of newly acquired memory
Reactivation & Reconsolidation
Memories are not consolidated, or stabilized, just once:
they can return to a labile state and need to be
reconsolidated, or restabilized, when reactivated
Experimental procedures
1.Participants learned object-location task in presence of the experimental odor
2.One group of subjects stayed awake.The other group of subjects went to sleep
3.learned an interference object-location task
4.Recall of the original object-location task was tested 30 min after interference
learning
(Each participant was also tested in a control condition in which, instead of odor,
odorless vehicle was presented during waking and SWS, respectively)
Results
Results
Conclusion
Reactivation during waking destabilized memory traces,
returning them to a labile state,
The same odor-cued reactivation stabilized memory traces
when induced during SWS
Neuronal correlates of reactivation
during waking
Old
memory
Retrival
Rminder
Active
memory
New situations
Reconsolidated
memory
Overwritten
memory
Neuronal correlates of reactivation
during waking
Neuronal correlates of reactivation
during SWS
To be continued
Reactivation
during SWS
stablization
Newly
encoded
memory
or
transient destabilization
fast restabilization
Strengthened
memory
Thank you