PHAR1059- Antineoplastic Drugs – Worksheet
Chemotherapy agents cause many adverse effects. What are the short and long-term adverse effects?

Short term adverse effects

Long-term adverse effects
What is the main difference between cell-cycle specific and cell-cycle non-specific classes of
chemotherapy?
Complete the following table for cell-cycle specific drugs:
Class
Subclass
Antimetabolites
Folate Antagonists
Purine Antagonists
Pyrimidine
Antagonists
Drug Examples
Cell Cycle
Phase
Action
Mitotic
Inhibitors
Vinca Alkaloids
Taxanes
Epipodophyllotoxin
Derivatives
(Topoisomerase II
inhibitors)
Topoisomerase I N/A
Inhibitors
Antineoplastic
Enzymes
N/A
What drug is associated with cholinergic diarrhea as an adverse effect? How is it treated?
Which class of drugs can impair pancreatic function?
What antidote is given when the extravasation of the following classes of chemotherapy drugs occurs:

Mitotic Inhibitors

Alkylating drugs
What is the mechanism of action of the alkylating class of non-cell cycle specific dugs?
List the 3 categories of alkylating drugs and two examples of drugs from each class.
Which alkylating drugs are associated with the following adverse effects:

Nephrotoxicity

Bone marrow suppression

Ototoxicity
What is the mechanism of action of cytotoxic antibiotics?
What precaution is needed when drugs such as Daunorubicin and Dactinomycin (cytotoxic antibiotics)
are to be given?
What is the most common adverse effect of cytotoxic antibiotics?
Which cytotoxic antibiotics are associated with heart failure and cardiomyopathy?
What role does hormone therapy have in the treatment of cancer?
Biological modifiers are new and advancing area of cancer treatment. How would monoclonal
antibiotics (MABs) help treat cancer?
What is the role of supportive drugs during chemotherapy treatment? How would a drug such as
Allopurinol help?