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CSCS Review

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CSCS Review
Vocab
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Adduction=Toward midline
Absolute= refers to just the actual wt. of body fat
Abduction= Away from midline
Aerobic Fitness= Ability to perform prolonged periods of work w/o getting tired
Ambient HR= HR during the day when you aren’t really doing anything but not truly resting
Antioxidants= protect against free radicals
Basal Metabolic Rate(BMR)= rate @ which body burns calories over 24 hr period while @
complete rest
Ectomorph= light build and slight muscular development
Endomorph= stocky build, wide hips and heavy fat storage
FITT= theory governing frequency, intensity, time and type of exercise
Free Radicals= Highly reactive molecules known to damage muscle fibers= inflammation,
fatigue, and suppressed immune system
High Impact Aerobics= exercises where both feet leave the ground simultaneously
Low Impact Aerobics= exercises where one foot stays in contact with the ground
Metabolism= all of the chemical processes that are taking place in your body to transfer food
and other substances into energy and waste
Obese= more than 35% body fat, over 100 billion fat cells
BMI Formulass
a) Wt. in lbs
x 703
(Ht. in In)^2
b) Wt. in Kg
(Ht. in In)^2
x10000
Circulatory System
Serves : 1. To conduct nutrients and oxygen to the tissues
2. To remove waste materials by transporting nitrogenous compounds to the kidneys and
carbon dioxide to the lungs
3. To transport chemical messengers(hormones) to target organs and modulate and integrate
the internal milieu of the body
4. To transport agents which serve the body in allergic, immune and infectious responses
5. to initiate clotting and thereby prevent blood loss
6. to maintain body temperature
7. to produce, carry and contain blood
8. to transfer body reserves, specifically mineral salts to areas of need
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Veins to the heart; Arteries from the heart
o Pulmonary vein exception
Hepatic Portal System- Blood draining intestines, pancreas, spleen + gall bladder goes through
system of veins in the liver before returning to circulation via inferior vena cava
Pulmonary Circuit- Blood oxygenated + depleted of metabolic waster products
Lymphatic Drainage- Fluids not reabsorbed into capillaries are transported via lymphatic system
Heart
o Pumps 72 times per minute (on Avg) and propels 4000 gals of blood to tissues daily
o Composed of:
▪ Endocardium(inner coat; epithelium)
▪ Myocardium (middle coat; cardiac muscle)
▪ Epicardium (external coat; epithelium and connective tissue)
▪ Impulse conduction system
o Cardiac Nerves:
▪ Modification of intrinsic rhythmicity of heart produced by cardiac nerves of
sympathetic and parasympathetic nervous system
▪ Sympathetic= Increase rate and force of heart and dilates coronary arteries
▪ Parasympathetic=(vagus nerve) opposite of sympathetic
▪ Visceral sensory(afferent) fibers from heart end in 1st four segments of the TSpine
o Cardiac Cycle:
▪ Alt. contraction and relaxation 72xper min. One cycle=.8 seconds
▪ 3 Phases
• 1. Atrial systole: 0.1sec
• 2. Ventricular systole: 0.3sec
• 3. Diastole: 0.4sec
▪ Actual rest period for each chamber is .7s for atria and .5s for ventricles
• Heart rest longer than @ work
Blood
o 2 Parts
▪ 1. Cells: 45%
▪ 2.Plasma: 55%
o Average volume 5 or 6 liters(7%BW)
o Plasma:
▪ 90% +water
▪ Rest- proteins, electrolytes, hormones, antibodies, nutrients and waste
• Isotonic
▪ Purpose: Role in respiration, circulation, coagulation, temp. regulation,
buffering and fluid balance
Major Hormones
Growth Hormone: Major stimulus of postnatal growth; induces precursor cells to differentiate and
secrete insulin-like growth factor which stimulates cell division and protein synthesis
Insulin: stimulates fetal growth, stimulates postnatal growth by stimulation secretion of IGF-1,
stimulates protein synthesis
Thyroid Hormones: permissive for growth hormone secretion and actions, permissive for development
of the CNS
Testosterone: stimulates growth at puberty in large part by stimulation the secretion of growth
hormone, causes eventual epiphyseal closure and stimulates protein synthesis
Estrogen- stimulates the secretion of growth hormone at puberty and causes eventual epiphyseal
closure
Cortisol- inhibits growth, stimulates protein catabolism
Nutrition
6 Key Nutrients
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Water
Protein
Minerals
Vitamins
Carbs
Fats
Water Key Points
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Normal production of water in a human is around 2500-2700 ml per day
Average adult composed of about 55-60% water
More water is required for children and during warm weather
Water acts as body’s solvent
Water can be found in intra + extra cellular tissue
Adults should take in 2-3L of fluid over the course of a normal day
Protein Key Points
1. Made of amino acids (AA)
2. AA broken down into essential and non essential
a. 9 AA must be found in diet and cannot be manufactured by body
3. 3 types
a. Complete
b. Incomplete
c. Complementary
4. Complete proteins are found in meats, cheese and poultry. Contain all 8 essential AA
5. Incomplete proteins are found in plants, nuts, grains and legumes
6. Complimentary proteins- foods that have to be combined to offer a complete protein
presentation
7. Digestion process of chymotrypsin, trypsin, carboxypeptidase and pepsin act upon proteins
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Proteins help in the production of antibodies and tissue healing
Proteins become energy source if carbs and fats are not available
Marasmus= starvation
Recommend 15% caloric intake to be protein
Uric Acid, Nitrogen and Hydrogen are all byproducts of protein breakdown
AA are incorporated into various structural and functional proteins including enzymes
Mineral Key Points
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Minerals help maintain the function of the various acids and bases in the body
About 75% of the minerals are found in bones and teeth as calcium and phosphorus
Minerals may function as catalyst for cell reactions
Magnesium, calcium, phosphorus , sodium and potassium are considered minerals
Minerals are usually incorporated into organic molecules, although some occur in inorganic
compounds or as free ions
Minerals create compounds in some cases
Homeostatic mechanics regulate mineral concentrations in the body
Minerals are responsible for about 4% of BW
Found in all types of body tissue
Don not create energy for the body
Calcium and phosphorus key in body development and maintenance
Sodium and potassium help trigger cell reaction potentials
Minerals found in unprocessed foods
Major Minerals
1. Calcium (Ca)
a. Sources: Milk, cheese, broccoli, turnips
b. Functions: Bones, clotting, cell wall integrity, conduction of nerve impulses
c. Disorders: Deficient clotting, poor bone structure and limited cell integrity
2. Chlorine (Cl)
a. Sources: Salt
b. Functions: Helps produce acid-base relationships that are balanced, helps with osmotic
pressures and the production of hydrochloric acid, helps regulate pH
c. Disorders: Excessive water loss may cause low levels of chlorine in the body
3. Magnesium (Mg)
a. Sources: Leafy vegetables, whole grains, legumes, milk
b. Function: Bones, teeth, function as enzymes, nerve conduction, functions in ATP
Production
c. Disorders: Nervous system dysfunction
4. Phosphorus (P)
a. Sources: Egg Yolk, Whole Grains, Meat, Milk
b. Function: Helps with calcification, maintains acid-base relationship, works as an enzyme,
occurs in phospholipids of cell membranes
c. Disorders: Rickets, poor bone structure
5. Potassium (K)
a. Sources: Fruits, whole grains, fish and poultry
b. Function: Nervous system conduction, acid-base relationship and pH regulation
c. Disorders: Nausea, weakness of muscles
6. Sodium (Na)
a. Sources: Salt, Fish, Poultry, Milk
b. Function: Acid-base relationship, nerve system conduction, uptake of glucose
c. Disorders: Nausea, weakness, muscles spasms, cramping
7. Sulfur (S)
a. Sources: Egg, cheese, nuts, meats
b. Function: Aids w/ vitamin B function and helps development of connective tissue, found
in insulin, biotin and mucopolysaccharides
Vitamins Key Points
1. Fat-Soluble vs Water Soluble
2. Fat Soluble: A, D, E, K
3. Water Soluble: C, B1, B2, B6, B12, Folic Acid and Niacin
Water Soluble Vitamins
1. Vitamin C- Ascorbic Acid
a. Sources: Citrus, strawberries, potatoes, tomatoes
b. Function: Helps with uptake of iron and cell membranes, closely related chemically to
monosaccharides
c. Disorders: Scurvy, Anemia, Pronounced bruising of tissue
2. Vitamin B1- Thiamine
a. Sources: Legumes, wheat germ, pork
b. Function: Helps with muscle and nerve function, active in the synthesis of essential
sugars
c. Disorders: Anorexia, nerve dysfunction, beriberi
3. Vitamin B2- Riboflavin
a. Sources: Enriched breads, milk, meats, greens
b. Function: Lip color, metabolic process of nutrients, eyes, can function as a coenzyme
c. Disorders: Weight Loss, eye dysfunction, and lips may become inflamed
4. Vitamin B6- Pyridoxine
a. Sources: Red Meats
b. Function: Hemoglobin production, synthesis of proteins
c. Disorders: CNS disorders, kidney stones and nausea
5. Vitamin B12- Cobalamin
a. Sources: Animal products only
b. Function: RBC production, protein breakdown
c. Disorders: Pernicious Anemia
6. Folic Acid- Folacin
a. Sources: Most foods
b. Function: RBC production and protein breakdown, coenzyme in the synthesis of DNA
c. Disorders: Anemia, Stomatitis
7. Niacin- Nicotonic Acid
a. Sources: Meats, Peanut Butter
b. Function: Growth, nervous system and digestive system
c. Disorders: Pellagra, Dermatitis
Fat Soluble Vitamins
1. Vitamin A-Retinol
a. Sources: Whole milk, fish, leafy vegetables, and yellow vegetables
b. Function: Vision, skin, teeth, stored in the liver
c. Disorders: Poor vision, xerophthalmia, bad skin
2. Vitamin D- Calciferol
a. Sources: Milk, fish oils, sun
b. Function: bones, also synthesized in the skin
c. Disorders: Teeth, bad bones structure, rickets
3. Vitamin E- Tocopherol
a. Sources: Leafy Vegetables, wheat germ
b. Function: Antioxidant, stabilizes RBC’s, stored in muscles and adipose tissue
c. Disorders: Anemia, RBC’s are broken down
4. Vitamin K- Menadione
a. Sources: Pork Liver, Leafy vegetables
b. Function: Helps with prothrombin for blood clotting
c. Disorders: Hemorrhagic Conditions
Carbohydrates Key Points
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Three types of carbs: polysaccharides, disaccharides, monosaccharides
Polysaccharides- glycogen, dietary fiber, and starch found in cereal, rice, corn pasta
Disaccharides- (double sugars)- maltose, lactose, sucrose, found in molasses, table sugar
Monosaccharides- (simple sugars)- Fructose, glucose, galactose found in fruit and honey
Energy in released from glucose by oxidation
If inadequate amounts of glucose available AA may be converted to glucose
Carbs provide energy and help in the breakdown of fat
Carbs can only be used in the from of simple sugars by the body
Primary processing and uptake of carbs occurs in the small intestine by the enzymes maltase,
sucrase, and lactose
Glucose is the simple sugar used by the CNS and glucose can be stored as glycogen until being
used later
High levels of carbohydrates can lead to weight gain and poor nutritional status
Studies indicate that approximately 55% of an adults intake is carbohydrates
Carbohydrates are absorbed as monosaccharides
Dietary fiber can be broken down in soluble and insoluble dietary fiber
Glucose is regulated by insulin and glucagon (hormone)
Educate clients to reduce simple sugars and encourage clients to eat more complex carbs
Fat Key Points
1. Excessive fats can lead to weight gain, stroke, and heart disease
2. There are two primary types of fat: Saturated fats and unsaturated fats
3. Saturated Fats- completely maximized number of hydrogen present.
a. Examples- eggs, chocolate, dairy, coconut oil, meats, usually solid at room temp
4. Unsaturated fats- usually liquid at room temp., do not have max # of hydrogen atoms present.
a. Examples- soybean and corn oil
5. Fats provide insulation to the body
6. Linoleic acid is an essential fatty acid
7. Cholesterol is obtained in foods of animal origin only
8. Fats help with the transportation of fat soluble vitamins
9. Fats act as an energy source when carbohydrates are unavailable
10. Fats help create linoleic acid which is an essential component not made in the body
11. Primary fat breakdown occurs in the small intestine, however, some is performed in the
stomach by gastric lipase
12. Fats can also be classified as visible or invisible
13. Visible fats: shortening, meats, margarine, butter
14. Invisible fats: cheese, milk, avocado
15. Recommend to you clients total intake of fat to be less than 30% of caloric intake
16. High Cholesterol is above 240mg/dL
17. Borderline-200-240 mg/dL
18. <200 mg/dL recommended
19. Recommend polyunsaturated fats to lower cholesterol
LDL vs HDL
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Atherosclerosis= plague causing hardening of the arteries
LDL less than 100mg/dL is optimal level. Less than 130mg/dL near optimal
High LDL= more than 160mg/dL or 130mg/dL or above= 2 or more CVD risk factors
1/3 to ¼ of blood cholesterol is carried by HDL
Ergogenic Aids
Caffeine
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Mobilizing fatty acids, which can be used as fuel, sparing glycogen stores
May benefit endurance athlete
Stimulant may help power events
Diuretic property lead to weight loss may benefit jumping events
Creatine
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Can enhance high intensity exercise and creatine levels in muscle
No increase in endurance
AA
o Aids in ATP resynthesis
o Maintains ATP/ADP Ratios
o In combination with/ PCr buffers H+
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Facilitates high energy phosphate transport from mitochondria to the contractile
proteins of skeletal muscle
Sodium Bicarbonate
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Buffers H+ (Lactic Acid)
Anabolic Steroids
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Side effects: liver tumors, jaundice, fluid retention and high BP, severe acne, trembling
Men: shrinking testicles, lower sperm count, infertility, baldness, development of breasts
Women: growth of facial hair, changes in menstrual cycle, enlargement of the clitoris and
deepened voice
Anatomy
Axial Skeleton
Consists of 80 bones forming (spine and thorax) and skull
Vertebral Column
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Composed 26 bones
7 Cervical, 12 Thoracic, 5 lumbar vertebrae, sacrum formed by fusion of 5 sacral vertebrae and
coccyx formed by fusion of 4 coccygeal vertebrae
Ribs and Sternum
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12 pairs of ribs attach to T-Spine post and sternum anteriorly
7 pairs of ribs articulate with sternum directly= fixed ribs
3 pairs of ribs articulate with sternum via cartilage
2 inferior pairs don’t attach anteriorly and are referred to as floating ribs
Skull
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22 bones fused together
Form face and cranium consist of 6 single bones
o 1. Occipital 2. Frontal 3. Ethmoid 4. Vomer 5. Sphenoid 6. Mandible
8 Paired bones
o 1. Parietal 2. Temporal 3. Maxillary 4. Palatine 5. Zygomatic 6. Lacrimal 7. Inferior
Concha 8. Nasal
Mandible is the only movable bone of the skull
Other Parts
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Middle ear bones ( ossicles)
Hyoid Bone= small U shaped
Appendicular Skeleton
126 Bones
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64 Upper
62 Lower
Characteristics of Bone
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Specialized type of connective tissue consisting of cells (osteocytes) embedded in a calcified
matrix
Encased by periosteum, connective tissue sheath
Central marrow cavity
Types of Bone
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Compact Bone
Spongy( Cancellous)
Compact Bone
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Lies within periosteum, forms outer region and appears dense
Living osteocytes and calcified matrix arranged in layers or lamellae
Lamellae circulatory arranged surrounding central canal, haversian canal which contains small
blood vessels
Spongy Bone
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Bars, spicules or trabeculae which forms lattice meshwork
Found @ ends of long bones and the inner layer of flat, irregular and short bones
Joints
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Ball and socket( ex. Hips and shoulder)
o All types of movement
Hinge (ginglymus) ( ex. Elbow and knee; interphalangeal joints)
o Motion in one plane
Rotating/ Pivot ( ex. Radius, ulna, atlas and axis)
o Only rotation permitted
Plane/ Gliding (tarsal and carpal bones)
o Sliding motion
Condylar ( metacarpi-phalangeal, temporomandibular)
o Two planes motion @ right angels to each other
Muscular System
Skeletal Muscles
650 skeletal muscles
Each muscle consists of many muscle fibers held together and surrounded by connective tissue
3 Units
1. Endomysium- connective tissue layer enveloping a single fiber
2. Perimysium- connective tissue layer enveloping a bundle of fibers
3. Epimysium- connective tissue layer enveloping the entire muscle
Structural Organization of a Muscle Fiber
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Fiber= single muscle cell
o Cell membrane- sarcolemma
o Multinucleated
o Composed of numerous cylindrical fibrils running entire fiber length
Myofilaments
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Thick and thin form contractile machinery of muscle and are made of proteins
54% by weight= myosin
Thick myofilaments= many myosin molecules oriented tail-end to tail-end at the center w/
myosin molecules staggered from center to the myofilament tip
Actin= Thin+ globular protein
Sarcoplasm- muscle cell cytoplasm
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Contains golgi complexes near the nuclei
Mitochondria between myofibrils and just below sarcolemma
Myofibrils surrounded by sarcoplasmic reticulum made of longitudinally arranged tubular
network (sarcotubules)
Complex( terminal cistern- T Tubules- terminal cistern) formed at this position = triad
o T-Tubules bring wave of depolarization of sarcolemma into the fiber thus into intimate
relationship w/ terminal cisternae
Excitation
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Contraction triggered by generation of action potential in muscle membrane
Motor neutrons lose myelin sheath when entering skeletal muscle
Branch to innervate a single muscle fiber= neuromuscular junction
Motor unit- Single motor neuron and all muscle fibers innervated by it
Motor end plate= specialized part of membrane lying under neuron
Contraction
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Huxley Sliding Filament Theory
o Thin and thick filaments slide past one another making and breaking chemical bonds as
they go
o No change in filament length
o H and I bands narrow during contraction
o A band remains the same
Muscle Twitch
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Muscle twitch= muscles response to a single max stimulus
Beginning of activity signaled by record of electrical activity in sarcolemma
Latent Period= Delay between imposition of stimulation and development of tension
Tetanus
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Summation= increased strength of contraction in response to volley of stimulus before
relaxation can occur
Tetanus= smooth and full contraction in response to very fast stimulation that causes individual
contraction to fuse
Energy Sources
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Energy In=Energy Out
ATP hydrolyzed by actomyosin to give ADP, Pi, and energy associated w/ cross bridge motion
Types of Muscle Fibers
1. White(fast) fibers
a. Rapidly contract
b. Fatigue quickly
c. Energy production via anaerobic glycolysis
d. Few mitochondria
2. Red (slow) fibers
a. Contract slowly
b. Fatigue slowly
c. Energy production via oxidative phosphorylation(aerobic)
d. Many mitochondria
3. Intermediate fibers
a. Structural and functional qualities of both
Lever Review
First class Lever
a. Fulcrum between the effort and load
Second class Lever
a. Fulcrum- Load- Effort
b. Load Close to Fulcrum
Third class Lever
a. Fulcrum- Effort-Load
Sarcomere Review
a. Z-Disk
a. Separates the sarcomere
b. No myosin @ Z-Disk
b. A-Band: The distance of one thick filament= two myosin
a. Does not change length
c. I-Band: Distance from the end of one thick filament to the beginning of the next thick filament
a. Becomes shorter during contraction
b. Entirely Actin
c. Marks margins of two adjacent sarcomeres. Each I-band technically lies within 2
sarcomeres
d. H-Zone: Distance between end of one thin filament to the beginning of the next thin filament
a. Becomes shorter during contraction
b. Entirely myosin
c. Completely within sarcomere- lies @ center
Six Actin interact with each myosin in hexagonal array
Three myosin can interact in triangular fashion with each actin
Myosin plays role of ATPase Actin-Binding Motor Protein
- When myosin bound to actin, ATP bound to myosin head
- W/ATP bound, myosin can detach from actin
- Once detached, myosin hydrolyzes bound ATP to ADP+Pi remain attached to Myosin head
- Then myosin reattaches to action
- Reattachment realeases Pi group, which strengthens actin and myosin interaction
- Power Stroke: ATP gone, myosin head undergoes conformational change, causing actin and
myosin to move relative to each other
- Myosin head releases ADP
- New ATP must bind to myosin, for myosin to release from actin to start new cross bridge
Relaxed state
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Tropomyosin bound to thin filament in absence of calcium
Troponin complex is periodically bound to thin filament to block actin and myosin interaction
Contracted state
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Calcium binds to troponin complex
Troponin-C removes itself from thin filament, Myosin can now bind
Neuromuscular Junction
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Active Zone: Electron-Dense patch of membrane at the end of a nerve, right at the
neuromuscular junction
o Vesicles @ membrane, mitochondria more proximal, away from active zone
Junctional fold right opposite active zone
Ach receptors on the muscle membrane highly concentrated right at nerve terminal
Muscle Development
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Mesenchymal cells from myoblasts
Myoblasts proliferate and from myotubes by fusing together, resulting in a large multinucleated
cell
*Muscle becomes multinucleated by fusing together of primitive myoblasts
Satellite Cells: These cells lie squeezed in-between the endomysium (basement membrane) of a
myofibril and the fibers themselves
- Developmentally they have the same origin as myotubes. They are myoblasts that did not fuse
with other myoblasts during development
- They proliferate to repair damaged muscles tissue
o They will divide to regenerate muscle, but regeneration my by incomplete
Muscle Regeneration
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When the muscle fibers are gone, all that is left is the basal lamina and reticular formation of the
endomysium
Satellite cells then migrate into empty endomysium
Macrophages come in to remove necrotic remnants(debris)
Muscle regeneration may be incomplete ( muscle atrophy or weakness)
Fiber splitting can occur, where satellite cell can generate smaller duplicated myofibril sections
from one original myofiber
Penniform Muscle: Muscles with a central tendon, used for strength and stability( Transverse
Abdmoinus)
Fusiform Muscle: Muscles w/a tendon on either side longitudinally, used for speed (Biceps)
Tanner Classification
-Classification of sexual maturity looks at pubic hair growth to determine development level
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Stage 1- Preadolescent has no pubic hair except for fine peach fuzz
Stage 2- Sparse growth of long, slightly darkened, downy hair around labia
Stage 3- Pubic hair becomes darker, coarser and curlier
Stage 4- more dense growth
Stage 5- Classic course, curly and extends to inner thighs
Gait Cycle
Stance period= 5 Phases
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Initial Contact
Loading Response
Midstance
Terminal Stance
Pre-Swing
Swing period= 3 Phases
1. Initial Swing
2. Mid Swing
3. Terminal Swing
Detraining
Short Term (5wks)
Causes significant changes in metabolic response to exercise, w/ decreased fat breakdown
during exercise and increased glucose reliance
Long Term(>5 wks)
More significant and dramatic changes than short term. Destruction of RBC’s(hemolysis) during
exercise
Fluid Intake Recommendations
(ACSM Guidelines on Fluid Intake for Exercise)
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Rec. that one drinks about 500mL (17fl oz) about 2 hrs prior to exercise
Should drink early and @ regular intervals to try and keep up with sweating rate
Ingest fluids cooler than ambient temp
Readily available
During intense exercise longer than 1 hr, carbs should be ingested @ rate of 30-60g/hr
Basics
Neuromuscular Efficiency
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Strength is directly related to efficiency of the neuromuscular system
Initial increases in first 8-10 weeks due to neuromuscular efficiency
Biomechanical consideration
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Position of tendon attachment
Length-Tension Relationship
Length of muscle determines tension that can be created
Varying lengths will produce varying tensions
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Determined by overlap of actin-myosin filaments
Overtraining
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Imbalance between exercise and recovery
Training exceeds physiological and psychological capacity of individual
Can have negative effect on strength training
May result in physiological and psychological breakdown
Injury, illness, and fatigue can be indicators
Physiology of Strength Development
Muscle Hypertrophy
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Hyperplasia- increased number of fibers
o Genetically determined and doesn’t seem to increase with training
Increased number of capillaries
Increased in dormant capillary activity to meet needs of muscle
Increase size and number of myofilaments
Actin and myosin- Reversibility- adaptations of muscle due to training can begin to
reverse within 48 hrs of removing training.
Periodization
Hypertrophy
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8-10 reps
1-6 weeks
65-79%
45-90 second rest
Shorter rest= greater hormonal response
Strength
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5-8reps
2-8 weeks
80-90%
3-5 mins rest
Assures complete recovery
Power
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1-4reps
90-107%
5-10 min rest
Key Formulas
Momentum= Mass x Velocity
Acceleration= Change in Velocity/ Total Time
Speed= Distance/Time
Work= Force x Distance
Power= Force*Distance = W/T
Time
Karvonen Formula: Accepted HR Range 60-80% max HRR
Target HR= % Intensity x HRR +RHR
**HRR= Heart Rate Reserve RHR= Resting Heart Rate
Max Heart Rate Formula
MHR x % Intensity
Heart Rate
ACSM recommends exercise prescribed as 55-90% MHr, or 50-85% VO2max or HR reserve
HGH
Acromegaly is side effect of too much HGH= widening of bones, organ enlargement, and metabolic
abnormalities
Beta-Agonists
Are chemically related to epinephrine and have effects of lipolysis and thermogenesis
*Fibrosis causes fibrous tissue to replace degenerating muscle fibers
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