MDD, often known as depression or clinical depression, is a serious mental health condition that
can have a significant impact on a person's everyday life. It can cause issues with sleeping,
eating, and working, for example. When left untreated, MDD can be quite severe. MDD has an
aetiology that is unknown. However, there are a number of factors that can raise your chances of
acquiring the disease. Brain chemistry can be affected by a mix of genes and stress, reducing the
ability to sustain mood stability. While it is impossible to anticipate who would be affected by
depression, there are several risk factors for MDD. There are a variety of factors to consider.
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Suffering from depression or other mental diseases in the past.
Depression, bipolar disorder, suicide, or alcoholism in the family.
Significant changes in your life.
Abuse of drugs and alcohol.
High levels of anxiety.
Trauma.
Certain medical conditions and drugs.
Some personality traits, such as poor self-esteem or a pessimistic outlook.
Abuse. Abuse of any kind, whether physical, sexual, or emotional, can make you more
susceptible to depression later in life.
Age. Elderly people are more likely to suffer from depression. Other circumstances, such
as living alone and lacking social support, can exacerbate this.
Some drugs. Some medications, such as isotretinoin (for acne), interferon-alpha (an
antiviral medicine), and corticosteroids, can raise your risk of depression.
Conflict. Personal problems or disagreements with family members or acquaintances might
lead to depression in someone who is biologically vulnerable to it.
A loss or death. Though natural, sadness or grief following the death or loss of a loved one
might increase the risk of depression.
Gender. Depressive women are around twice as likely as depressed males. Nobody knows
why. Hormonal changes that women go through at various stages of their lives could be a
factor.
• Genes. A history of depression in the family may raise the risk. Depression is regarded to be
a complex trait, implying that there are likely many separate genes, each with a minor effect,
rather than a single gene that contributes to disease risk. Depression's genetics, like those of
most psychiatric disorders, aren't as uncomplicated as those of purely hereditary diseases like
Huntington's chorea or cystic fibrosis.
• Important occasions. Even happy events like starting a new job, graduating, or marrying
might trigger sadness. Moving, losing a job or money, getting divorced, or retirement can all
be stressful events. Clinical depression, on the other hand, is never merely a "natural"
reaction to stressful life events.
• Other personal issues social isolation as a result of various mental diseases or being
expelled from a family or social group can all contribute to the development of clinical
depression.
• Serious medical conditions. Depression can occur as a result of a serious disease or be
prompted by another medical condition.
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• Misuse of substances. Nearly one-third of those who struggle with substance abuse also
suffer from significant or clinical depression. Even if drugs or alcohol help you feel better for
a short time, they will eventually worsen your depression.