Motif search-function prediction Biological Networks Dr. Noha Zelai Motif search-function prediction Motif • A motif is a short conserved sequence pattern associated with distinct functions of a protein or DNA. • It is often associated with a distinct structural site performing a particular function. • A typical motif, such as a Zn-finger motif, is ten to twenty amino acids long. Biological Networks • All aspects of life activities in living cells are mediated and regulated by a vast number of networks, comprising a wide spectrum of components, starting with simple biomolecules and ending with the whole organism, and functioning within a precisely organized tight framework. • The number of biological networks and pathways within the living cell is considerably huge, being dependent on the structural complexity and functional capabilities of the cell. • Biological networks are organized deterministic systems that constitute the framework of life activities of the whole structural spectrum of living matter that includes biomolecules, e.g., nucleic acids and proteins, cell organelles, e.g., mitochondria and cytoskeleton, whole cells, tissues, organs and, at last, the whole organism The design of biological networks Exercise • Search in Uniprot to find what is the Zn-finger Exercise • Search in Uniprot to find what is the Zn-finger motif • https://www.uniprot.org/help/zn_fing
