Part 2 Immune System Overview
1. Adaptive immunity is _______________, while Innate immunity is _______________.
2. __________ acts immediately upon entry of microorganisms:
a. Adaptive immunity
b. Innate immunity
c. Adaptive & Innate immunity
d. Neither
3. True/False: Adaptive immunity takes several days to be fully functional.
4. _______________ can ingest and destroy several types of bacteria and is not considered a type of APC.
5. ______ helps facilitate the process of phagocytosis.
a. IgM
b. IgA
c. IgG
d. IgE
6. Which of the following are antibody functions (Humoral Immunity)? (Select all that apply)
a. Neutralize toxins
b. Opsonize bacteria
c. Impedes the process of phagocytosis
d. Neutralizes viruses
7. Which of the following are key contributors to the Opsonization process? (Select all that apply)
a. IgE
b. IgG
c. C3b component
d. C4b component
8. Which of the following are NOT requirements for Antibody synthesis?
a. B cells
b. Helper T cells
c. Neutrophils
d. Dendritic cells
9. ________ & ________ activate B cells.
a. IL-3 & IL-4
b. IL-4 & IL-6
c. IL-5 & IL-4
d. IL-2 & IL-5
10. Plasma cells secrete large quantities of _____________? (Select all that apply)
a. B cells
b. Antibodies
c. Helper T cells
d. Immunoglobulins
11. Which of the following is the CORRECT sequence for production of antibodies?
a. Activated T cell  antibody  plasma cell
b. Plasma cell  B cell  antibody
c. Activated B cell  plasma cell  antibody
d. IL-4 & IL-2  activated B cell  plasma cell  antibody
12. Activated B cells differentiate to produce _plasma cells_.
13. Interleukins are ____________ to certain processes, while T & B cells are ____________ to certain
processes.
a. Specific, Not specific
b. Not specific, Not specific
c. Specific, Specific
d. Not specific, specific
14. Which Antigen receptor is on the surface of B cells?
a. IgG
b. IgA
c. IgM
d. IgE
15. True/ False: Antigen receptor (B cell receptor) is on the surface of CD4 positive and the CD8 positive B
cell.
16. CD4 cells are also called __________ but CD8 cells are __________.
a. Cytotoxic cells, Helper T cells
b. Helper T cells, Cytotoxic cells
c. T cells, Helper T cells
d. Helper T cells, T cells
17. Which of the following are Cell-mediated immunity functions? (Select all that apply)
a. Kill viruses & healthy cells
b. Inhibit fungi and parasites
c. Kill infected cells and viruses
d. Inhibit intracellular bacteria
18. Match the following immune responses to the corresponding order:
Response
a. Immune cell stimulation for a specific response
Recognition
b. Reaction targeting the organism for destruction
Activation
c. Organism identification by specific immune cells
19. The correct order in Immune response is:
a. Recognition, Response, Activation
b. Activation, Recognition, Response
c. Response, Recognition, Activation
d. Recognition, Activation, Response
20. True/False: Antibody mediated (humoral) immunity defends against intracellular, pyogenic bacteria,
staphylococci and streptococci.
21. CD8 cells act by
a. Directly destroying a virus infected cell
b. Defending against intracellular bacteria
c. Defending against extracellular bacteria
d. Directly destroying a bacteria infected cell
22. CD4 cells and macrophages defend against _______________ _______________.
23. MHC II is associated with ______ while MHC I is associated with ______.
a. CD4, IL-1
b. CD8, CD4
c. CD4, CD8
d. IL-2, IL-4
24. ****See chart on Slide 11****
25. What is used by the immune system to recognize its own material vs foreign material?
a. MLC proteins
b. MHC proteins
c. MHG proteins
d. MNC proteins
26. Class I major histocompatibility complex proteins are located on: (Select all that apply)
a. Surface of almost all cells
b. Surface of almost all human cells
c. Surface of macrophages
d. Surfaces of B cells
27. Class II major histocompatibility complex proteins are located on: (Select all that apply)
a. Surface of almost all cells
b. Surface of almost all human cells
c. Surface of macrophages
d. Surfaces of B cells
28. Which of the following are important for differentiation of B cells into Plasma cells? (Select all that
apply)
a. IL-1
b. IL-4
c. IL-2
d. IL-5
29. What is considered a normal CD4:CD8 ratio?
a. 3:1
b. 2:1
c. 1:2
d. 0:2
30. A ratio of 0.7 is a good predictor that a patient ____ have HIV/AIDS; a ratio of 1.3 is a good predictor
that a patient _____ have HIV/AIDS.
a. May, may not
b. May not, may
c. May not, still may not
31. A ratio of ____ is indicative of a strong immune system while a ratio of ____ is indicative of a
weakened immune system.
32. During cell-mediated immunity a virus that is released by an infected cell is ingested by what type of
APC? (Select all that apply)
a. Neutrophil
b. Dendritic cell
c. Macrophage
d. Monocyte
33. True/False: Cell-mediated immunity involving a viral epitope, the virus is presented in association with
a I major histocompatibility complex protein which uses a TCR on the CD4 cell.
34. Macrophages serve as a source of _____?
a. IL-2
b. IL-1
c. IL-4
d. IL-5
35. Activated CD4 cells have what two primary roles?
a. Production of macrophages
b. Production of IL-1
c. Production of IL-2
d. Production of IL-4, IL-5
36. True/ False: Viral proteins can be broken down into smaller peptides through antibody mediated
immunity.
37. Which of the following can present viral epitopes in association with Class II MHC proteins and activate
CD4 cells?
a. T cells & macrophages
b. Neutrophils & monocytes
c. B cells & macrophages
d. CD4 helper cells & leukocytes
38. CD4 helper cells produce _____ & _____ which leads to the induction of B cell differentiation to
____________.
a. IL-3 & IL-5, plasma cells
b. IL-2 & IL-4, B cells
c. IL-1 & IL-2, helper T cells
d. IL-4 & IL-5, plasma cells
39. ****See slide 20 for chart****
40. Class I MHC is associated with _______________, which are _______________ T cells.
41. All of the following are roles of IL-2 EXCEPT:
a. Activation of helper cells
b. Activation of B cells
c. Activation of cytotoxic cells
d. Activation of macrophages
42. True/False: The SILCAAT study had more AIDS patients then the patients in the ESPRIT study.
43. True/False: IL-2 offers maximum benefit versus ART alone.
44. True/False: Interleukin two increase CD4+ cells in HIV-1 patients.
45. True/False: Patients have a greater risk of opportunistic infections and death with IL-2 when compared
to ART alone.
46. Which of the following are TRUE regarding the IL-2 HIV infection studies? (Select all that apply)
a. ESPRIT patients had a higher CD4 count
b. Patients taking corticosteroids could not participate in the study because IL-2 therapy is
negatively affected by corticosteroids
c. ESPRIT had more patients than SILCAAT
d. SILCAAT patients had a higher CD4 count
47. Present antigen associated with class I MHC proteins are _______________.
48. Present antigen associated with class II MHC proteins are _______________.
49. The above processes (in question 47 & 48) are what type of involvement?
a. Acquired
b. Innate
c. Phagocytosis
d. Antibody
50. Which of the following are NOT considered innate involvement?
a. Phagocytosis
b. Cytokine production
c. Inflammation
d. All of the above are involved with innate immunity