HLA
Gevoelig
Aandoening
Serotype (RR)
Acute uveïtis anterior
B27
Ziekte van Addison
DR3
Alopecia areata
Beschermend
Allel
Serotype
Reference
Allel
B*2702/3/4/5/6/9
(Brewerton and others 1973; Chang and others 2005; Ehlers and others
1974; Khan 1995; Khan 2000; Konno and others 1999)
(Barker and others 2005; Bilbao and others 2003; Thorsby and Lie
2005)
DR17
DRB1*0403
DQ1
DQB1
DR4
DRB1*04
DR3
DRB1*03
(Colombe and others 1999; Entz and others 2006; Marques Da Costa
and others 2006; McElwee and others 2001; McLachlan 1993)
DR5
DR6
DR7
DR11
Spondylitis ankylosans
B27
(John B. Imboden 2007; Reveille 2006) (Thorsby and Lie 2005) (Wei
and others 2004) (Sims and others 2004; Zhang and others 2004)
B60
B61
Syndroom van Goodpasture (antistoffen tegen het
glomerulaire basale membraan)
DR2
(Burns and others 1995) (Perl and others 1981)
(Phelps and Rees 1999)
(Yu and others 1999)
DR4
DRB1*0404
DR15
DRB1*1501
DQ8
HLA
Gevoelig
Aandoening
Serotype (RR)
Antifosfolipidensyndroom
Autisme
Beschermend
Allel
DM
DMA*0102
DR13
DRB1*1302
DR53
DRB4*0101
DQ6
DQB1*0604/5/6/
7/9
DQ8
DQB1*0302
A2
DR4
Serotype
Reference
Allel
(Arnett and others 1999)
(Arnett and others 1999)
(Caliz and others 2001; Sanchez and others 2004)
(Polleux and Lauder 2004; Torres and others 2001; Torres and others
2006)
DRB1*04
DR11
Auto-immune hyperthyreoïdie
DR3
Auto-immune pancreatitis
DR4
DRB1*0405
DQ4
DQB1*0401
Syndroom van Behçet
B51
Birdshot chorioretinpathie
A29
(Kotsa and others 1997)
(Kawa and others 2002; Kloppel and others 2005)
(Kera and others 1999; Mizuki and others 1997; Sakane and others
1999)
A*2901/2
(Bloch-Michel and Frau 1991; Levinson and others 2004; Nussenblatt
and others 1982; Priem and Oosterhuis 1988)
DQ3
DQB1*0301
(Delgado and others 1996; Mihai and Sitaru 2007; Okazaki and others
2000; Sachs and others 1986)
DR4
DRB1*0403
DR11
DRB1*1101
B12
Bulleus pemphigoid
HLA
Gevoelig
Aandoening
Serotype (RR)
Coeliakie
DQ2
Beschermend
Allel
Serotype
DQB1*02013
Reference
Allel
(Bao and others 1999; Bourgey and others 2007; Hoffenberg and others
2003; Kagnoff 2005; Louka and Sollid 2003; Ludvigsson and others
2006; Margaritte-Jeannin and others 2004)
DQ3
DR3
DR4
DR7/11
DQA1*05013
Cryoglobulinemische vasculitis
Herpetiforme dermatitis
B8
(Amoroso and others 1998; Congia and others 1996; Lenzi and others
1998)
DQ2
DQB1*0201
DQ7
DQB1*0301
DR3
DRB1*0301
DR11
DRB1*1101
DR3 (15.9)
(Cecil and others 2008; Spurkland and others 1997)
DQA1
DRB1
Reuscelarteritis
DR4
(Weyand and others 1992; Weyand and others 1994)
See Anti-glomerular basement membrane disease
Syndroom van Goodpasture
Ziekte van Graves
Cw7
DR3 (3.7)
Cw3
DRB1*03
Cw16
(Cecil and others 2008; McLachlan 1993; Simmonds and Gough 2004;
Simmonds and others 2007; Thorsby and Lie 2005)
HLA
Gevoelig
Aandoening
Serotype (RR)
Ziekte van Hashimoto (thyreoïditis)
Beschermend
Allel
DR2
DRB1*02
DQ5
DQA1*0501
Serotype
DR3
DR6
DR11 (3.2)
DQw1
Reference
Allel
(Cecil and others 2008; Hashimoto and others 2005; McLachlan 1993;
Tamai and others 1994; Tandon and others 1991; Yanagawa and others
1994)
Purpura van Henoch-Schönlein
B35
(Amoli and others 2002a; Amoli and others 2004; Amoli and others
2002b)
Idiopathische membraneuze glomerulonefritis
DR3 (12.0)
(Cecil and others 2008; Freedman and others 1994; Martinetti and
others 1992)
Type 1-diabetes mellitus
DQ2
DQB1*0201
(2.4-10)
DQ3
DQB1*0302
(6.4-14)
DQ3
DQB1*0301
DQ6
DQB1*06023
(0.02-0.15)
DQ5
DQB1*0501
DR1
DRB*01013
DR7
DR2 (0.19)
Juveniele idiopathische artritis
DR14
DR3 (3.3-10)
DRB1*0301
DR4 (6.4)
DRB1*0401/5
DR15
DRB*15013
DR8
DQA1*0102
(Barker and others 2005; Cecil and others 2008; Johansson and others
2003; Pociot and McDermott 2002; Pugliese and others 1995; Ziegler
and others 1991)
DRB1*1401
(Thorsby and Lie 2005)
HLA
Gevoelig
Aandoening
Serotype (RR)
Multiple sclerose
Beschermend
Allel
DQ1
DQ6
A2
DQB1*0602
DR2 (4.1-12)
Myasthenia gravis
Serotype
Allel
A*0201
DRB1*01/DRw5
3
DR1/DQ5
DRB1*01/DQB1
*0501
DR13/DQ6
DRB1*13/DQB1
*0603
DR4
DRB1*04
DR15
DRB1*1501
DRB1*15021
DR51
DRB5*0101
DQA1*0103
A1
Reference
(Barcellos and others 2003; Cecil and others 2008; Fernandez and others
2004; Fogdell-Hahn and others 2000; Hillert and Olerup 1993; Sospedra
and Martin 2005)
(Carlsson and others 1990; Cecil and others 2008; Djabiri and others
1997; Thorsby and Lie 2005; Vieira and others 1993)
B8 (3.4)
DR1
DRB1*0101
DR3 (2.5)
DRB1*0301
DQ2
DQB1*0201
DQA1*0501
Myocarditis
DR4
(Carlquist and others 1991; Cecil and others 2008; Limas and others
1990)
Narcolepsie
DQB1*0602
(>40-129)
(Cecil and others 2008; Ellis and others 1997; Mignot and others 1997)
Pemphigus vulgaris
A26
(Amar and others 1999; Cecil and others 2008; Cox and others 1999;
Delgado and others 1997; Gazit and Loewenthal 2005; Mobini and
others 1997)
B38
HLA
Gevoelig
Aandoening
Serotype (RR)
Beschermend
Allel
Serotype
Reference
Allel
G
DQ3
DQB1*0302
DR4 (14.4)
DRB1*0402
DR14
DRB1*1401
DQB1*0503
Pernicieuze anemie
B7
(Ungar and others 1977)
B12
DR2
DR4
Postpartum thyreoïditis
DR4 (5.3)
(Cecil and others 2008; Parkes and others 1996; Rios and others 2006)
DR5
Primaire biliaire cirrose
DR8
Primaire scleroserende cholangitis
DQA1*0102
DR11
DRB1*11
DRB1*0801
DR13
DRB1*13
A1
(Donaldson and Norris 2002; Mitchell and others 2001; Norris and
others 2001; Wiencke and others 2001)
B8
DQA1*0501
DQ2
(Donaldson and others 2006; Mullarkey and others 2005; Talwalkar and
Lindor 2003; Underhill and others 1992)
DQB1*0201
HLA
Gevoelig
Aandoening
Serotype (RR)
Beschermend
Allel
Serotype
Reference
Allel
DRB3*0101
DR3
DRB1*0301
DR13
DRB1*1301
Psoriasis vulgaris
C
Cw6 (10-13.3)
Reactieve artritis (Yersinia)
B27 (17.6)
(Cecil and others 2008; Colmegna and others 2004)
Reactieve artropathie, met inbegrip van het
syndroom van Reiter
B27 (37.0)
(Cecil and others 2008; Leirisalo-Repo 2005)
Reumatoïde artritis
DR1 (2-5)
(Cecil and others 2008; Hernandez-Pacheco and others 2003; Thorsby
and Lie 2005)
(Gudjonsson and others 2002; Thorsby and Lie 2005);
DR4
Seropositief
DR4 (7.2)
Dw4 (25.8)
Dw14 (47)
Dw4/Dw14 (116)
Pauciarticulair
DR5 (2.9)
DP2 (3.9)
DQA1*0201
Reumatisch hartlijden
DQA1*0501
DQ3
DQB1*0301/2
DR7
DRB1*0701
(Stanevicha and others 2003; Visentainer and others 2000;
HLA
Gevoelig
Aandoening
Serotype (RR)
Siccasyndroom
Beschermend
Allel
DR16
DRB1*1602
DQ2
DQB1*02
Serotype
Reference
Allel
(Cecil and others 2008; Smyth and others 2007)
DR3 (9.7)
Syndroom van Sjögren
DR3 (5.6)
DR53
(Cecil and others 2008; Manoussakis and others 2004; Pease and others
1993)
DRB4*0101
Subacute thyreoïditis
B35
(Thorsby and Lie 2005)
Systemische lupus erythematosus
DR2
(Cecil and others 2008; Graham and others 2002; Hartung and others
1992; Lu and others 1999; Manoussakis and others 2004; Stephens and
others 1991)
DR3 (5.8)
Ziekte van Takayasu
A24
(Kerr and others 1994; Kimura and others 1996; Salazar and others
2000)
B52
DR2
3
The risk has not been assessed separately for this allele.
RR: relative risk of the disease; i.e. how many times more frequent the disease is in those having the corresponding HLA molecule compared to those lacking it.
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