BIOM 600 Cell Biology and Biochemistry
Fall 2013
Director:
John Weisel ~ 898-3573 ~ weisel@mail.med.upenn.edu
1054 BRB II/III
Co-Directors:
Theme I:
Mark Lemmon ~ 898-3072 ~ mlemmon@mail.med.upenn.edu
Mickey Marks ~ 898-3204~ marksm@mail.med.upenn.edu
Theme II:
Kevin Foskett ~ 898-1354 ~ foskett@mail.med.upenn.edu
Theme III:
John Weisel ~ 898-3573 ~ weisel@mail.med.upenn.edu
Theme IV:
Xiaolu Yang ~ 573-6739 ~ xyang@mail.med.upenn.edu
BGS Coordinator:
Colleen Dunn ~ 898-2792 ~ dunncoll@mail.med.upenn.edu
TAs:
Kurt Engleka ~ 898-0252 ~ kengleka@mail.med.upenn.edu
Kelsey Speer ~kspeer@mail.med.upenn.edu
Christopher Yarosh ~ yaroshc@mail.med.upenn.edu
Lectures:
Monday, Wednesday and Friday from 10:30 am – 12:00 pm
Austrian Auditorium unless otherwise noted
Textbook:
Molecular Biology of the Cell, Eds. Alberts, et al. 5th edition
DATE
TOPIC
LECTURER
THEME I: COMPARTMENTATION
W Sept 4
Intro to Class/Protein Purification
J. Weisel
M. Ostap
F Sept 6
Immunological Techniques
M. Marks
M Sept 9
Basics of Protein Structure and Folding
K. Ferguson
W Sept 11
Themes in Compartmentation/
Membrane Structure
M. Lemmon
F Sept 13
Cellular Quality Control
P. Oliver
M Sept 16
Protein Biogenesis and Translocation
into the Endoplasmic Reticulum
M. Lemmon
W Sept 18
Protein Folding and Assembly in the
Endoplasmic Reticulum
M. Marks
F Sept 20
Microscopy Techniques
A. Stout
DATE
TOPIC
LECTURER
M Sept 23
Mechanisms of Vesicular Transport
QUIZ: may be taken anytime between 8-10 am
before class start
M. Marks
W Sept 25
Golgi Function and Protein Sorting in
the Secretory Pathway
C. Giraudo
F Sept 27
Endocytosis and Lysosomal Degradation
M. Marks
M Sept 30
Exocytosis and Secretion
M. Birnbaum
W Oct 2
Nuclear Architecture and Nucleocytoplasmic
Transport
B. Black
F Oct 4
Mitochondria Function and Biogenesis
A. Dancis
F Oct 4
TA Help Session/Review
*3:30 – 5:00 pm
TAs
M Oct 7
Exam Review (during normal class time)
TAs
M Oct 7
Exam 1 ~ 6:00 – 9:00 pm in Dunlop Auditorium
THEME II: MEMBRANES AND SOLUTE TRANSPORT
W Oct 9
Protein-Protein Interactions
K. Ferguson
F Oct 11
Introduction to Kinetics
R. Kohli
M Oct 14
Principles of Ion Transport
K. Foskett
W Oct 16
Ion Channels 1
T. Hoshi
W Oct 16
Membrane Problem Set Help Session
*3:30 – 5:00 pm
K. Foskett
F Oct 18
Ion Channels 2
T. Hoshi
M Oct 21
Integrated Functions of Ion Channels
K. Foskett
THEME III: CELL MOTILITY AND ADHESION
W Oct 23
Microtubules
E. Holzbaur
F Oct 25
Microtubule-Based Motility
E. Holzbaur
M Oct 28
Actin Cytoskeleton
R.Dominguez
W Oct 30
Actin-Based Motility
M. Ostap
DATE
TOPIC
LECTURER
F Nov 1
Adhesion
J. Weisel
M Nov 4
Cell-Extracellular Interactions
J. Weisel
W Nov 6
Mitosis and Cytokinesis
E. Bi
W Nov 6
TA Help Session/Review
*3:30 – 5:00 pm
TAs
F Nov 8
Exam Review (during normal class time)
TAs
F Nov 8
Exam 2 ~ 6:00 – 9:00 pm in Dunlop Auditorium
THEME IV: SIGNAL TRANSDUCTION
M Nov 11
Introduction to Signal Transduction
Receptor Tyrosine Kinases
M. Birnbaum
W Nov 13
G-Protein Coupled Receptors and G-Proteins
D. Manning
F Nov 15
Signaling by Small GTPases
Phosphoinositides
M. Chou
M Nov 18
Calcium Signaling
Phospholipases
K. Foskett
W Nov 20
Nuclear Receptor Signaling
M. Lazar
F Nov 22
Serine and Threonine Phosphorylation
F. Lee
M Nov 25
Metabolism
M.Birnbaum?
Cycles and Feedback
M. Lemmon
W Nov 27
Cancer Metabolism
K. Wellen
F Nov 29
No Class-Thanksgiving Break
M Dec 2
Cell Cycle
F. Luca
W Dec 4
Autophagy
S. Cherry
F Dec 6
Apoptosis
X. Yang
M Dec 9
Signal Transduction in Health and Disease
X. Yang
W Dec 11
TA Help Session/Review
(during normal class time)
TAs
F Dec 13
Exam Review (during normal class time)
TAs
F Dec 13
Exam 3 ~ 6:00 – 9:00 pm in Dunlop Auditorium
Faculty Lecturers
Erfei Bi – ebi@mail.med.upenn.edu – 573-6676
Morrie Birnbaum – birnbaum@mail.med.upenn.edu – 898-5001
Ben Black – blackbe@mail.med.upenn.edu – 898-5669
Sara Cherry – cherrys@mail.med.upenn.edu – 746-2384
Margaret Chou – mmc@mail.med.upenn.edu – 267-426-9228
Andy Dancis – adancis@mail.med.upenn.edu – 573-6275
Roberto Dominguez – droberto@mail.med.upenn.edu – 573-4559
Kate Ferguson – ferguso2@mail.med.upenn.edu – 573-1207
Kevin Foskett – Foskett@mail.med.upenn.edu – 898-1354
Claudio Giraudo – giraudoc@mail.med.upenn.edu – 267-425-2124
Erika Holzbaur – holzbaur@mail.med.upenn.edu – 573-3257
Toshi Hoshi – hoshi@mail.med.upenn.edu – 573-7305
Rahul Kohli – rkohli@upenn.edu – 573-7523
Mitch Lazar – lazar@mail.med.upenn.edu – 898-0198
Frank Lee – franklee@mail.med.upenn.edu – 898-4701
Mark Lemmon – mlemmon@mail.med.upenn.edu – 898-3072
Frank Luca – fluca@mail.vet.upenn.edu – 573-5664
Dave Manning – manning@mail.med.upenn.edu – 898-1775
Mickey Marks – marksm@mail.med.upenn.edu – 898-3204
Paula Oliver – paulao@mail.med.upenn.edu – 267-426-2839
Mike Ostap – ostap@mail.med.upenn.edu – 573-9758
Andrea Stout – astout@mail.med.upenn.edu
John Weisel – weisel@mail.med.upenn.edu – 898-3573
Katy Wellen – wellenk@mail.med.upenn.edu – 746-8599
Xiaolu Yang – xyang@mail.med.upenn.edu – 573-6739