EDUCATION
Sep 2007 - present
Jan 2011 - Aug 2014
Sep 2010 - Aug 2011
Sep 2003 - Aug 2006
Sep 2003 - Aug 2006
Sep 2000 - Aug 2003
University College London
MBBS
University College London
PhD
University College London
BSc (Physiology and Pharmacology) 1st Class Honours
St Peter & Paul’s Lyceum
Lyceum Baccalaureate (19.9/20, Distinction)
Institute of Maths & Science
Advanced Extension Award (Mathematics, Merit), A-levels
(Mathematics [A], Further Mathematics [A], Physics [A], Statistics
[A], Chemistry [A], Ancient Greek History [B]), AS-levels (Biology
[A]).
Katholiki Gymnasium
Gymnasium Baccalaureate (20/20, Distinction)
MEDICAL/RESEARCH EXPERIENCE
May 2012 - July 2012 Research fellowship on ‘Intestinal tissue engineering in vivo using
organoid units’ (Saban Research Institute, Childrens Hospital Los
Angeles, Dr. T. Grikscheit)
Sep 2010 - Jan 2011 Clinical audit on ‘Vascular function post-elective thoracic aortic
aneurysm repair’ (Heart Hospital, Mr. J Yap)
Sep 2009 - May 2010 Research fellowship on ‘Development of stroke model in rats’
(Centre of Advanced Biomedical Imaging, UCL, Prof. RJ
MacAllister, Prof. M Lythgoe)
Sep 2008 - May 2009 Library project on ‘Pathophysiology of cerebral ischemia
reperfusion injury’ (Rayne Institute, UCL, Prof. RJ MacAllister)
May 2008 - July 2008 Research fellowship on ‘Remote ischaemic preconditioning and
post-conditioning in humans’ (Vascular physiology unit, UCL
Institute of Child Health, Prof. RJ MacAllister)
June 2006 - July 2006 Student observership in ophthalmology (Department of
Ophthalmology, Larnaka General Hospital, Cyprus, Dr. A.
Kyriakides)
AWARDS/PRIZES
Sep 2014
July 2014
June 2014
June 2013
Sep 2012 - Sep 2015
Sep 2011 - Sep 2013
Sep 2011 - Sep 2013
President’s Award - ISPR conference 2014 (shortlisted)
Young Investigator Award - BAPS conference 2014 (shortlisted)
Young Investigator Award - EUPSA conference 2014 (shortlisted)
Young Investigator Award - EUPSA conference 2013
‘Intestinal tissue engineering in vivo through the combination of
mouse crypt organoid units and decellularised matrices’ (£2,000)
AG Leventis Award for academic excellence (£15,000)
Graduate School Travel Award (£1,500)
ICH Dean Travel Award (£600)
Sep 2012 - Sep 2013
June 2012
May 2011 - Jul 2011
Jan 2011 - Aug 2014
June 2009
June 2008
Sep 2006 - Sep 2012
Medical Research Council Centenary Award
‘Amniotic fluid stem cell transdifferentiation using extracellular
matrix components from decellularised matrices’ (£45,398)
ICH Poster Competition Award, 2nd Prize
‘Three-dimensional scanning electron microscopy for fine tuning of
pulmonary decellularisation protocols’ (£200)
UCL Charlotte and Yule Bogue Research Fellowship
“Intestinal tissue engineering in vivo through the combination of
mouse crypt organoid units and decellularised matrices” (£3,336)
Medical Research Council MB PhD Studentship
“Intestinal tissue engineering using natural acellular matrices”
(£49,000)
Merit in Clinical Sciences, MBBS Year 2
Merit in Clinical Sciences, MBBS Year 1
Republic of Cyprus Scholarship for academic excellence (£15,000)
TEACHING EXPERIENCE
Sep 2014 - present
Biomedical Sciences tutor with Tavistock Tutors
Oct 2013 - Aug 2014 Co-supervisor of MSc student in Molecular Medicine (Imperial
University), Heleni Topouzi (£2,200)
Oct 2013 - Aug 2014 Co-supervisor of MSc student in Molecular Medicine (Imperial
University), Carla Villela (£2,200)
Oct 2013 - May 2014 Co-supervisor of iBSc student in Physiology (MBBS student,
UCL), George F Bingham (£300)
Oct 2012 - Aug 2013 Co-supervisor of MSc student in Molecular Medicine (Imperial
University), Eleni Petra (£2,200)
Oct 2012 - Aug 2013 Co-supervisor of MSc student in Molecular Medicine (Imperial
University), Marivic Narciso (£2,200)
Oct 2012 - May 2013 Co-supervisor of iBSc student in Physiology (MBBS student,
UCL), Lucy Papaioannou (£300)
Oct 2012 - May 2013 Co-supervisor of iBSc student in Physiology and Pharmacology
(MBBS student, UCL), Daniel Ditchfield (£300)
Oct 2011 - Aug 2012 Co-supervisor of MSc student in Molecular Medicine (Imperial
University), Fanourios Georgiades (£2,200)
Oct 2011 - May 2012 Co-supervisor of iBSc student in Physiology (MBBS student,
UCL), Amy Dickinson (£300)
Oct 2011 - May 2012 Co-supervisor of iBSc student in Physiology (MBBS student,
UCL), Dorota H Klepacka (£300)
Sep 2011 - Aug 2014 Co-supervisor of student obervership (MBBS, King’s College),
Athanasios Tyraskis
May 2011 - Aug 2011 Co-supervisor of summer intern (BSc graduate, Bath University),
Fanourios Georgiades
Sep 2010 - Jun 2012 Senior mentor in medical school
Sep 2009 - Jun 2010 Mentor in medical school
COURSES
Mar 2014
Cochrane Review Training Course - Analysis Methods for
Systematic Reviews (RA3)
Feb 2014
Oct 2013
Oct 2013
Oct 2012
Mar 2009
Sep 2005
Advanced Image Processing Course (ImageJ, Fiji, Inkscape),
Institute of Child Health
Cochrane Review Training Course - The Methods Section of the
Protocol (RA2)
Cochrane Review Training Course - Beginning a Systematic Review
(RA1)
Advanced Microscopy Course, University College London
Animal Handling Course (Modules 1-4), Biological Services,
University College London
Advanced Life Support, Limassol General Hospital, Cyprus
PUBLICATIONS
Book chapters
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Cells derived from the amnion. Maghsoudlou P, De Coppi P. In Stem Cell
Transplantation, 2012.
Tissue engineering and stem cell research. Maghsoudlou P, Loukogeorgakis SP, De
Coppi P. In Seminars in Paediatric Surgery, 2013.
Tissue engineering for oesophageal diseases: a new option for oesophageal
replacement. Totonelli G, Maghsoudlou P, De Coppi P. In Regenerative Medicine
Applications in Organ Transplantation, 2013.
Papers
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Amniotic Fluid Stem Cells Are Cardioprotective Following Acute Myocardial
Infarction. Bollini S, Cheung KK, Riegler J, Dong X, Smart N, Ghionzoli M,
Loukogeorgakis SP, Maghsoudlou P, Dubé KN, Riley PR, Lythgoe MF, De Coppi
P. Stem Cells and Development. 2011 Nov; 20(11): 1985-94.
A rat decellularized small bowel scaffold that preserves villus-crypt architecture
for intestinal regeneration. Totonelli G, Maghsoudlou P, Garriboli M, Riegler J,
Orlando G, Burns AJ, Sebire NJ, Smith VV, Fishman JM, Ghionzoli M, Turmaine
M, Birchall MA, Atala A, Soker S, Lythgoe MF, Seifalian A, Pierro A, Eaton S, De
Coppi P. Biomaterials. 2012 Apr; 33(12): 3401-10.
Detergent enzymatic treatment for the development of a natural acellular matrix
for oesophageal regeneration. Totonelli G, Maghsoudlou P, Georgiades F,
Garriboli M, Koshy K, Turmaine M, Ashworth M, Sebire NJ, Pierro A, Eaton S, De
Coppi P. Pediatric Surgery International. 2013 Jan; 29(1): 87-95.
Esophageal tissue engineering; a new approach for esophageal replacement.
Totonelli G, Maghsoudlou P, Fishman JM, Orlando G, Ansari T, Sibbons
P, Birchall MA, Pierro A, Eaton S, De Coppi P. World Journal of Gastroenterology.
2012 Dec; 18(47): 6900-7.
Skeletal muscle tissue engineering: which cell to use? Fishman JM*, Tyraskis A*,
Maghsoudlou P, Urbani L, Totonelli G, Birchall MA, De Coppi P. Tissue
Engineering Part B. 2013 Dec; 19(6): 503-15. (*These authors contributed equally)
Discarded human kidneys as a source of ECM scaffold for kidney
regeneration technologies. Orlando G, Booth C, Wang Z, Totonelli G, Ross CL,
Moran E, Salvatori M, Maghsoudlou P, Turmaine M, Delario G, Al-Shraideh Y,
Farooq U, Farney AC, Rogers J, Iskandar SS, Burns A, Marini FC, De Coppi P,
Stratta RJ, Soker S. Biomaterials. 2013 Aug; 34(24): 5915-25.
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Preservation of micro-architecture and angiogenic potential in a pulmonary
acellular matrix obtained using intermittent intra-tracheal flow of detergent
enzymatic treatment. Maghsoudlou P, Georgiades F, Tyraskis A, Totonelli G,
Loukogeorgakis SP, Orlando G, Shangaris P, Lange P, Delalande JM, Burns AJ,
Cenedese A, Sebire NJ, Turmaine M, Guest BN, Alcorn JF, Atala A, Birchall MA,
Elliott MJ, Eaton S, Pierro A, Gilbert TW, De Coppi P. Biomaterials. 2013 Sep;
34(28): 6638-48.
Recent developments in therapies with stem cells from amniotic fluid and placenta.
Loukogeorgakis SP, Maghsoudlou P, De Coppi P. Fetal and Maternal Medicine.
2013 Aug; 24(03): 148-68.
A decellularization methodology for the production of a natural acellular intestinal
matrix. Maghsoudlou P, Totonelli G, Loukogeorgakis SP, Eaton S, De Coppi P.
Journal of Visualized Experiments. 2013 Oct; (80).
Person-specific health promotion in the health-care setting: an exploratory study.
Razzaki S*, Theodorou A*, Maghsoudlou P, Protopapa E, Beynon H. The Lancet.
2013 Nov; 382: S83. (*These authors contributed equally)
Tissue engineering of the oesophagus. Maghsoudlou P, De Coppi P. Seminars in
Pediatric Surgery. 2014 Jun; 23(3): 127-34.
Sheep CD34+ amniotic fluid cells have haematopoietic potential and engraft after
autologous in utero transplantation. Shaw SW, Blundell MP, Pipino C, Shangaris
P, Maghsoudlou P, Ramachandra DL, Georgiades F, Boyd M, Thrasher AJ, Porada
CD, Almeida-Porada G, Cheng PJ, David AL, De Coppi P. Stem Cells. 2015 Jan;
33(1): 122-32.
Isolation of esophageal stem cells with potential for therapy. Maghsoudlou P,
Ditchfield D, Klepacka DH, Shangaris P, Urbani L, Loukogeorgakis SP, Eaton S,
De Coppi P. Pediatric Surgery International. 2014 Dec; 30(12): 1249-56.
Organ bioengineering for the newborn. Maghsoudlou P, Urbani L, De Coppi P.
Seminars in Pediatric Surgery. 2014 Oct; 23(5): 314-23.
A potential platform for developing 3D tubular scaffolds for paediatric organ
development. De Mel A, Yap T, Cittadella G, Hale LR, Maghsoudlou P, de Coppi
P, Birchall MA, Seifalian AM. Journal of Materials Science. 2015 Mar; 26(3): 141.
Decellularized human liver as a natural scaffold for liver bioengineering and
transplantation. Mazza G, Rombouts K, Hall A, Urbani L, Luong TV, Al-Akkad W,
Longato, L, Brown D, Maghsoudlou P, Dhillon AP, Fuller B, Davidson B, Moore
K, Dhar D, De Coppi P, Malago M, Pinzani M. Nature Scientific Reports. 2015
Aug; 5: 13079.
OP-1 artificial oesophagus engineering in a 3D dynamic culture. Camilli C, Urbani L,
Scottoni F, Crowley C, Wong RR, Maghsoudlou P, Fallas ME, Lowdell M, Birchall
M, Cossu G, De Coppi P. Journal of Pediatric Gastroenterology and Nutrition. 2015
Oct; 61(4): 509.
The human pancreas as a source of pro-tolerogenic extracellular matrix scaffold for
a new generation bioartificial endocrine pancreas. Peloso A, Urbani L, Katari R,
Maghsoudlou P, Alvarez M, Purroy C, Mcquilling J, Sittadjody S, Farney AC,
Iskandar SS, Rogers J, Stratta RJ, Opara EC, Piemonti L, Soker S, De Coppi P.
Annals of Surgery 2015 (In print).
X-ray phase contrast tomography for microstructural assessment of acellular organ
scaffolds in regenerative medicine. Hagen CK, Maghsoudlou P, Totonelli G,
Diemoz PC, Endrizzi M, Rigon L, Menk RH, Arfelli F, Dreossi D, Longo R, Brun
E, Coan P, Bravin A, De Coppi P, Olivo A. Nature Scientific Reports 2015 (In print).
INVITED TALKS/LECTURES
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Developmental signals in the extracellular matrix. Developmental Biology Meeting,
UCL Institute of Child Health, 08 February 2012.
The development of decellularized intestinal scaffolds that preserve the villus-crypt
axis. Saban Institute for Research, Childrens’ Hospital Los Angeles, 26 June 2012.
Tissue engineered intestine by combining decellularized scaffolds and organoid
units. Department of Biological Sciences, University of Cyprus, 21 Dec 2012.
Attempting to harness the power of Prometheus: Intestinal tissue engineering.
MBPhD Symposium, University College London, 31 Jan 2013.
Tissue engineering of the intestine and liver using natural acellular matrices. MRC
Laboratory for Molecular Cell Biology, University College London, 01 Apr 2014.
Building an artificial lung. Respiratory Failure and Lung Transplant meeting, Great
Ormond Street Hospital, 24 Apr 2014.
Intestinal Tissue Engineering. Stem Cells and Regenerative Medicine meeting, UCL
Institute of Child Health, 17 June 2014.
CONFERENCE PRESENTATIONS
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An innovative method of gut decellularisation that maintains the original
microstructure of the intestine. Totonelli G, Garriboli M, Ghionzoli M,
Maghsoudlou P, Riegler J, Orlando G, Atala A, Burns A, Seifalian A, S Eaton,
Pierro A, De Coppi P. European Paediatric Surgery Conference, 2011 (Oral).
Biomechanical characteristics of a natural human intestinal matrix. Totonelli G,
Garriboli M, Maghsoudlou P, Darbyshire A, Soker S, Orlando G, Thapar N,
Seifalian A, Pierro A, Eaton S, De Coppi P. International symposium on paediatric
surgery, 2011 (Oral).
Sheep amniotic fluid derived CD34+ stem cells engraft in NOD-SCID gamma mice
and in lambs after prenatal autologous transplantation. Steven SW, David AL,
Blundell M, Howe S, Pipino C, Maghsoudlou P, Lin J, Porada CD, Thrasher A, De
Coppi P. European Society of gene and cell therapy conference, 2011 (Poster).
Can amniotic fluid stem cells be an option for autologous cell/gene therapy in
utero? Shaw SW, Pipino C, Maghsoudlou P, Waddington SN, David AL, De
Coppi P. International Stem Cell Conference, 2011 (Poster).
Haematopoietic stem cells derived both from sheep and human amniotic fluid
engraft after transplantation: potential for in utero autologous gene/cell therapy.
Shaw SW, David AL, Blundell M, Lee KH, Howe S, Pipino C, Maghsoudlou P,
Lin J, Atala A, Eaton S, Pierro, Porada CD, Thrasher A, De Coppi P. American
Paediatric Surgery Association Conference, 2012 (Oral).
Production and characterization of a lung natural acellular scaffold in the rat and
sheep. Maghsoudlou P, Tyraskis A, Georgiades F, Vernay B, Totonelli G,
Klepacka D, Pierro A, Eaton S, De Coppi P. European Paediatric Surgery
Conference, 2012 (Oral).
A comparison of two techniques of decellularising skeletal muscle and their effects
on crucial extracellular matrix components. Tyraskis A, Maghsoudlou P, Pierro A,
Eaton S, De Coppi P. European Paediatric Surgery Conference, 2012 (Poster).
Human Amniotic Fluid Stem Cells engraft in the Foetal Mouse after Prenatal
Xenotransplantation Shangaris P, Shaw SW, Pipino C, Lee KH, Maghsoudlou P,
Lin J, David AL. European Paediatric Surgery Conference, 2012 (Oral).
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Production and characterization of a natural human intestinal matrix. Totonelli G,
Maghsoudlou P, Garriboli M, Pierro A, Eaton S, De Coppi P. Wake Forest
institute for regenerative medicine annual retreat, 2012 (Oral).
Production and characterization of a lung natural acellular scaffold in the rat and
sheep. Maghsoudlou P, Tyraskis A, Georgiades F, Vernay B, Totonelli G,
Klepacka D, Pierro A, Eaton S, De Coppi P. Wake Forest institute for regenerative
medicine annual retreat, 2012 (Oral).
Oesophageal tissue engineering combining decellularised oesophageal scaffolds and
CD34+ oesophageal epithelial stem cells. Maghsoudlou P, Klepacka D, Dickinson
A, Georgiades F, Totonelli G, Pierro A, Eaton S, De Coppi P. International Stem
Cell Conference, 2012 (Poster).
Third trimester c-kit(+) human amniotic fluid stem cells can migrate to the
haematopoietic system of the foetal mouse after prenatal xenotransplantation. Shaw
SW, Lee KH, Pipino C, Maghsoudlou P, Shangaris P, David AL, De Coppi P.
International Stem Cell Conference, 2012 (Poster).
Lung natural acellular scaffolds can be easily obtained using the detergent-enzymatic
treatment in small and large animal models. Maghsoudlou P, Tyraskis A,
Georgiades F, Vernay B, Totonelli G, Klepacka D, Pierro A, Eaton S, De Coppi P.
Tissue engineering and regenerative medicine international society conference, 2012
(Poster).
Isolation of CD34+ epithelial stem cells and decellularised oesophageal scaffolds
holds potential for the production of a tissue-engineered oesophagus.
Maghsoudlou P, Klepacka D, Dickinson A, Georgiades F, Totonelli G, Pierro A,
Eaton S, De Coppi P. Tissue engineering and regenerative medicine international
society conference, 2012 (Oral).
Electron microscopy for the three-dimensional study of a natural human colonic
matrix. Totonelli G, Maghsoudlou P, Garriboli M, Turmaine M, Burns A, Thapar
N, Pierro A, Eaton S, De Coppi P. Tissue engineering and regenerative medicine
international society conference, 2012 (Oral).
Liver regeneration with the use of amniotic fluid derived-stem cells and natural
acellular scaffolds. Georgiades F, Maghsoudlou P, Shangaris P, Shaw SW, De
Coppi P. International Stem Cell Conference, 2012 (Poster).
Liver tissue engineering with the combination of natural acellular scaffolds that
mimic original tissue architecture and hepatocytes. Maghsoudlou P, Georgiades F,
Smith H, Totonelli G, Loukogeorgakis SP, Shangaris P, Ditchfield D, Papaioannou
L, Urbani L, Pierro A, Eaton S, Gissen P, De Coppi P. British Association of
Paediatric Surgery Conference, 2013 (Oral).
Comparison between different methods of preservation to store decellularised
oesophagi for tissue engineering purposes. Maghsoudlou P, Urbani L,
Papaioannou L, Dee R, Loukogeorgakis SP, Shangaris P, Ditchfield D, Spinelli V,
Menikou M, Pierro A, Seifalian A, Eaton S, De Coppi P. British Association of
Paediatric Surgery Conference, 2013 (Poster).
Natural acellular scaffolds produced with the detergent-enzymatic method mimic
original tissue architecture and promote cell growth. Maghsoudlou P, Papaioannou
L, Georgiades F, Smith H, Totonelli G, Loukogeorgakis SP, Shangaris P, Pierro A,
Eaton S, Gissen P, De Coppi P. European Society for Paediatric Gastroenterology
Hepatology and Nutrition Conference, 2013 (Oral).
Comparison of decellularisation methods for the production of an oesophageal
natural acellular scaffold in the rat. Maghsoudlou P, Papaioannou L, Totonelli G,
Loukogeorgakis SP, Shangaris P, Pierro A, Eaton S, Gissen P, De Coppi P.
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European Society for Paediatric Gastroenterology Hepatology and Nutrition
Conference, 2013 (Poster).
Tissue engineered small intestine in vivo from the combination of organoid units
and natural acellular scaffolds. Maghsoudlou P, Levin D, Totonelli G, Speer A,
Hou X, Barthel E, Dreyfuss J, Grant C, Loukogeorgakis SP, Garcia S, Shangaris P,
Urbani L, Pierro A, Eaton S, Grikscheit T, De Coppi P. European Paediatric
Surgery Conference, 2013 (Oral, Young Investigator Award).
Tissue engineered small intestine in vivo following seeding of organoid units on
decellularised intestinal matrices. Maghsoudlou P, Levin D, Totonelli G, Speer A,
Hou X, Barthel E, Dreyfuss J, Grant C, Loukogeorgakis SP, Garcia S, Shangaris P,
Urbani L, Pierro A, Eaton S, Grikscheit T, De Coppi P. International Stem Cell
Conference, 2013 (Poster).
Comparison between different methods of preservation to store decellularised
oesophagi for tissue engineering purposes. Maghsoudlou P, Urbani L,
Papaioannou L, Dee R, Loukogeorgakis SP, Shangaris P, Ditchfield D, Spinelli V,
Menikou M, Pierro A, Seifalian A, Eaton S, De Coppi P. International Stem Cell
Conference, 2013 (Poster).
Haematopoietic engraftment of amniotic fluid stem cells following in utero
transplantation. Loukogeorgakis SP, Shangaris P, Bertin E, Maghsoudlou P,
Blundell M, Urbani L, Ramachandra D, Thrasher A, Pozzobon M, David AL, De
Coppi P. International Stem Cell Conference, 2013 (Poster).
Muscle extracellular matrix characterization at single fibre level comparing three
techniques of decellularising large skeletal muscle using an intravascular approach.
Urbani L, Maghsoudlou P, Collins-Hooper H, Tyraskis A, Tommasini F, Torelli S,
Eaton S, K Patel, De Coppi P. European Molecular Biology Conference, 2014
(Oral).
Mouse crypt organoids repopulate decellularised intestinal scaffold in vitro.
Maghsoudlou P, Urbani L, Foglizzo V, Meran L, Eaton S, Li V, De Coppi P.
European Paediatric Surgery Conference, 2014 (Oral, Young Investigator Award).
Tissue engineering of oesophagus in vivo by combining decellularised scaffold and
mesangioblasts. Maghsoudlou P, Urbani L, Camilli C, Milan A, Tommasini F,
Zanini A, Loukogeorgakis SP, Shangaris P, Meran L, Eaton S, De Coppi P. British
Association of Paediatric Surgery Conference, 2014 (Oral, Peter Paul Rickham Prize)