S1.1
Preparation and bio-application of inorganic/organic hybrid
nanocomposites using hyperbranched polymers as templates
Xinyuan Zhu
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University,
800 Dongchuan Road, Shanghai 200240, China (xyzhu@sjtu.edu.cn)
Abstract
Inorganic nanocrystals exhibit unique size- and shape-dependent properties and are
of great interest in many applications. During the past decades, significant progress
has been made in the synthesis, characterization, shape control, and self-assembly
of nanocrystals. To further improve their properties, especially the solubility and
processability, nanocrystals are frequently modified, or coated by different polymers.
The resultant inorganic/organic hybrid nanocomposites integrate the characteristic
properties of nanocrystals and polymers together, illustrating potential applications.
Hyperbranched polymers are one important subclass of dendritic polymers. Benefiting
from their three-dimensional globular architecture, numerous cavities, and plenty
of peripheral functional groups, hyperbranched polymers offer a capability of in-situ
preparing nanocrystals with controlled size, which provides a simple surface coating
approach for nanocrystals. The precursor ions can be readily bound in the interior
nanocavities of hyperbranched polymers, further reacting gives the inorganic/organic
hybrid nanocomposites. Recently, a variety of hyperbranched polymers, including
cationic hyperbranched polymers, multiarm hyperbranched polymers, supramolecular
multiarm hyperbranched polymers, and dynamic hyperbranched polymers, have
been prepared in our research group. By utilization of these functional hyperbranched
polymers as nanoreactors, various polymer-coated nanocrystals are obtained. The
nanocrystals prepared within hyperbranched polymers exhibit the potential applications
in biodetection, antimicrobial, gene transfection, and drug delivery.
Acknowledgements: This work is sponsored by China National Funds for Distinguished
Young Scientists (21025417).
References
1. Y. F. Zhou, W. Huang, J. Y. Liu, X. Y. Zhu, D. Y. Yan, Adv. Mater. 2010, 22, 4567-4580.
2. R. J. Dong, Y. F. Zhou,; X. Y. Zhu, Acc. Chem. Res. 2014, 47, 2006-2016.
3. D. L. Wang, T. Y. Zhao, X. Y. Zhu, D. Y. Yan, W. X. Wang, Chem. Soc. Rev. 2014, DOI: 10.1039/C4CS00229F.
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Short Biography
Xinyuan Zhu received his B.Sc. and M.Sc. degrees at Donghua University, and obtained
his Ph.D. degree at Shanghai Jiao Tong University in the group of Prof. Deyue Yan.
Following academic appointments at the School of Chemistry and Chemical Engineering
in Shanghai Jiao Tong University (1997-2003), he joined the BASF research laboratory
at the ISIS in Strasbourg as a post-doctoral researcher. He came back to China in 2005,
and became a full professor for Polymer Science and Engineering at Shanghai Jiao Tong
University in the same year. His major interests focus on the controlled preparation
and biomedical applications of functional polymers with special architectures, such as
dendritic polymers and supramolecular polymers.
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