New Heart Care System based on
UT-Heart for Tailor-made Medicine
Prof. Toshiaki Hisada, Ph.D. in Eng. Univ. of Tokyo
Prof. Seiryou Sugiura, Ph.D. in MD. Univ. of Tokyo
Yoshimasa Kadooka, Ph.D. in Sci. Fujitsu Ltd.
•Collaborative research with Hisada Lab. of the University of Tokyo
•Supported by Japan Science and Technology Agency
Copyright 2012 FUJITSU LIMITED
Results of computational simulation by using
UT-Heart
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Copyright 2012 FUJITSU LIMITED
What we are aiming at.
P-V loop
mechanics
Tension
Multi-physics
X-bridge
Glucose
Biochemistry
glycolys
is
ATP
lactate
Na + Ca ++
Channels
Electrical
activity
K+
Molecular
function/structure
10-9m
Action potential
Cell
10-2m
ECG
Orga
n
100m
Human body
Multi-scale
Integration
Understanding
of knowledge
of human body
Discovery
2
2
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Construction of numerical model based on CT-images
Geometry
CT-scan images
Imbedding to
the torso
model
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3
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Pumping Principle of the Heart as a Blood Pump
Sinoatrial node
Electrophysiology
Pressure
100μm
volume
Excitation-Contraction Coupling
Myocardium
fee
db
ac
ks
Organ
Cell
4
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Fiber direction
Fiber
Fiberorientation
orientation
Atrium
Ventricles
endo
mid
epi
5
5
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Tetrahedral FEM model for mechanics
Voxel model for EP analysis
Torso
structure
Excitation
propagation
Heart
y
19,088,161 nodesuctivit
nd
o
c
c if ic organ
e
p
S
ach
e
r
fo
664,334 elements
2,561,750 DOF
fluid
Deformation
435,227 elements
1,668,669 DOF
30,819,249 nodes
(Total 49,425,860 nodes )
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6
(total ～4.2 million DOF)Copyright 2012 FUJITSU LIMITED
Measurement of Electrocardiogram (ECG)
 Comparison of ECG measurement between heart simulator and
human heart
Cardiac Pumping
Potential Distribution
on torso surface
Cardiac Excitation
Lead II ECG
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Planning of Surgery for Dilative Cardiomyopathy
 Surgery Planning of “Batista” by Heart Simulator
Contractile force: 100%
Plan A
Aneurysm
Necrotic myocardium
Contractile force: 30%
Before surgery
Plan B
？
Quantitative Prediction (QP) of
Pressure - Volume
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QP of Stress – Strain
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Visualization System
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New Medical System to realize Tailor-made
Medicine in the Cloud
Heart Simulator
Pa tient data
Cardiac Excitation Propagation
Micro Numerical Cell
Ion channel model in Cell
Fluid and Structure Interaction
Surgery planning,
Prediction of effect
Blood pressure, electrocardiogram,
and blood test
Interactive Visualization
System
Echo
Valves
Relational model for
Excitation and Contraction
Diagnostic support
Micro Model
Corona ry Circulation
CT・MRI
Peta-scale Computer
Prediction of
administering effect
Medical information integration data base
Electrical Care Card
Taylor-made Medical Treatment
by Heart Simulator
T reatment for Intractable disease
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Other approaches for medical therapy based on
computer simulation: Examples
 Image-based modeling and simulation of artery
circulatory system disease such as aneurysm
and arteriosclerosis:
Oshima Lab. In the University of Tokyo
 Medical planning project in Zuse-Institute Berlin
Computer Assisted
Cranio-Maxillofacial
Surgery
Reconstruction
of Knee
Anatomy for the
Analysis of Knee
Kinematics
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Oncological
Liver Surgery
Planning
ENT-Surgery under
consideration of
optimal nasal air
flow
Copyright 2012 FUJITSU LIMITED
Issues regarding Standardization
 To establish a security guide line to prevent the leaking of
patients data and to implement it to all related system
 To establish a common data format to match an anonymized
data with the corresponding patient raw data
 To integrate the localized specifications of DICOM* data
Administration
DB
Patients data
(anonymous)
Simulation Center
Patient data
(anonymous)
Patient data
(raw)
*Digital Imaging and
Communication
in Medicine
CT・MRI
ID:0002
ID:0001
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Security Level and Universal QoS
 Protection for DoS Attack
 To guarantee Persistent Service and Emergency Response without any service
interruption
 To guarantee the minimum security level and QoS for all Telcos
Heart Center
Telco A
Telco B
Telco C
Telco D
Security A
QoS A
Security B
QoS B
Security C
QoS C
Security D
QoS D
 International Leased Line Service across Several Telcos
 Not Best Effort, but Band-guaranteed System with Priority Control
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Which regulation should be applied?
International Heart Center
established in Country A
Regulation A
Conflict
Conflict
Regulation A
Country A
Regulation B
Country B
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Regulation C
Country C
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Copyright
Copyright
2010
2012
FUJITSU
FUJITSU LIMITED
LIMITED