Product datasheet
Anti-DYNC1I2 antibody ab96288
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Overview
Product name
Anti-DYNC1I2 antibody
Description
Rabbit polyclonal to DYNC1I2
Tested applications
WB
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Zebrafish
Immunogen
Recombinant protein fragment, corresponding to a region within amino acids 129 and 376 of
Human DYNC1I2
Positive control
HeLa whole cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw
cycles.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab96288 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
WB
Abreviews
Notes
1/500 - 1/3000. Predicted molecular weight: 71 kDa.
Target
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex
that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate
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dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of
vesicles and organelles along microtubules. The intermediate chains mediate the binding of
dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membranetransport, such as Golgi apparatus, late endosomes and lysosomes.
Sequence similarities
Belongs to the dynein intermediate chain family.
Contains 7 WD repeats.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR. The phosphorylation status of
Ser-90 appears to be involved in dynactin-dependent target binding.
Cellular localization
Cytoplasm > cytoskeleton.
Anti-DYNC1I2 antibody images
Anti-DYNC1I2 antibody (ab96288) at 1/1000
dilution + HeLa whole cell lysate at 30 µg
Predicted band size : 71 kDa
Western blot - DYNC1I2 antibody (ab96288)
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