Product datasheet
Anti-FREM2 antibody ab117612
2 Images
Overview
Product name
Anti-FREM2 antibody
Description
Rabbit polyclonal to FREM2
Tested applications
WB, ELISA, IHC-P, ICC
Species reactivity
Reacts with: Human
Predicted to work with: Mouse
Immunogen
Synthetic peptide conjugated to KLH, corresponding to 19 internal sequence amino acids of
Human FREM2.
Positive control
Human Breast and Human Kidney tissues.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze /
thaw cycle.
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab117612 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
Use at an assay dependent concentration. Predicted molecular weight: 351 kDa.
ELISA
Use at an assay dependent concentration.
IHC-P
Use a concentration of 5 µg/ml.
ICC
Use at an assay dependent concentration.
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Target
Function
Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for
maintenance of renal epithelia. May be required for epidermal adhesion.
Involvement in disease
Defects in FREM2 are a cause of Fraser syndrome (FRASS) [MIM:219000]. Fraser syndrome is
a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear
abnormalities, renal agenesis and congenital heart defects.
Sequence similarities
Belongs to the FRAS1 family.
Contains 5 Calx-beta domains.
Contains 12 CSPG (NG2) repeats.
Domain
The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift
upon binding.
Cellular localization
Cell membrane.
Anti-FREM2 antibody images
ab117612, at 5 µg/ml, staining FREM2 in
Formalin-fixed, Paraffin-embedded Human
breast tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - Anti-FREM2
antibody (ab117612)
ab117612, at 5 µg/ml, staining FREM2 in
Formalin-fixed, Paraffin-embedded Human
Kidney tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - Anti-FREM2
antibody (ab117612)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Terms and conditions
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