Product datasheet
Anti-Tau 13 antibody [B11E8] ab19030
1 Abreviews
Overview
Product name
Anti-Tau 13 antibody [B11E8]
Description
Mouse monoclonal [B11E8] to Tau 13
Tested applications
WB, IP
Species reactivity
Reacts with: Human
Immunogen
Synthetic peptide corresponding to the N-terminus of human Tau.
General notes
The antibody recognizes 45-60 kDa isoform of human Tau-13.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw
cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, 1% BSA, PBS, Ascites
Purity
Immunogen affinity purified
Primary antibody notes
The antibody recognizes 45-60 kDa isoform of human Tau-13.
Clonality
Monoclonal
Clone number
B11E8
Isotype
IgG1
Applications
Our Abpromise guarantee covers the use of ab19030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
1/1000. Predicted molecular weight: 79 kDa.
IP
1/500.
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Target
Relevance
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of
tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link
certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major
component of paired helical filaments (PHF)and neurofibrillary lesions in Alzheimer's disease
(AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the
destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the
affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous
system disorders. Numerous serine/threonine kinases, including GSK 3 beta, PKA, Cdk 5, and
casein kinase II can phosphorylate tau.
Cellular localization
Cytoplasmic and Plasma membrane
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