Product datasheet
Anti-TRKA+B antibody [1.A.37] ab18137
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Overview
Product name
Anti-TRKA+B antibody [1.A.37]
Description
Mouse monoclonal [1.A.37] to TRKA+B
Specificity
Recognizes TrKA/trKB Receptors.
Tested applications
WB, IP
Species reactivity
Reacts with: Human
Immunogen
Purified trKB receptors from insect cells (sf9) transfected with Baculovirus.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or 80°C. Avoid freeze / thaw cycle.
Storage buffer
Preservative: None
Constituents: 0.1M Tris HCl. pH 7.5
Purity
Protein A purified
Clonality
Monoclonal
Clone number
1.A.37
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab18137 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
Use at an assay dependent dilution. Predicted molecular weight: 92 kDa.
IP
Use at an assay dependent dilution.
Target
Relevance
Neurotrophins activate tyrosine kinase receptors of the TRK family (TRKA, TRKB and TRKC)
and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not
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appear to directly transduce NGF signals, this receptor appears to increase the responsiveness
of the TRK receptors and plays a role in the retrograde transport of neurotrophin signals from
axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is
tabulated by Barbacid (1994). NGF binds with high affinity and activates the TRKA tyrosine
kinase receptor, which is apparently responsible for signal transduction. BDNF activates the
TRKB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine
kinase receptor, but can also activate TRKA and TRKB receptors in certain cell systems. NT-4
primarily activates the TRKB tyrosine kinase receptor, which it shares with BDNF.
Cellular localization
Plasma membrane
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Terms and conditions
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