Chapter 12 ?’s
Read “HACs” on pg. 241 and answer questions 1-4.
1. What does HAC stand for?
2. What essential pieces of the chromosome must be present to withstand several cell divisions?
3. What is a megabase?
4. What is the importance of HACs in medicine?
Polyploidy:
5. How does most polyploidy occur?
Aneuploidy:
6. What is nondisjunction?
7. Draw a rough sketch of diagram 12.12.
8. Look at figure 12.12 and explain, in your own words, 2 ways cells can become monosomic or trisomic.
Read A Personal Look at Klinefelter Syndrome on pg. 252.
9. Why was it such a relief for Stefan to discover that he has KS?
10. What is the notation used to characterize the KS phenotype?
11. List 3 symptoms of KS.
Read Ashley’s Message of Hope on page 253.
12. What causes Cri-du-chat?
13. What suggestions are given for parents of a child with 5p- syndrome?
14. What suggestions are given for students in the health field?
Read about Translocations starting on page 253.
15. Name and define 2 types of translocations.
16. Which type has a more negative prognosis and why?
17. Answer question number 1 on page 261. (parts a-e)