Molecular Genetics BSCI410
The exam will be Nov. 18, 2010. In addition to reviewing these topics, you should be able to
answer questions like those on the homework.
Revised review material will be available after all lectures have been given, before Nov. 9.
------------------------------------------------------------------------------------------------------------Study material.
This study guide covers material for the third exam:
Transcription, post-transcriptional gene expression, gene mapping, positional cloning, LOD scores,
complex traits and types of allele.
Be able to define, discuss, and explain the following concepts:
promoter
transcription factor
epigenetics
DNase hypersensitivity
ChIP-Seq
heterochromatin
dosage compensation
Xist RNA
polyadenylation signal
U1 snRNP
pan editing
exportins
NMD
RNAi
miRNA
FISH
informative meioses
haplotype
complex traits
QTL mapping
genetic heterogeneity
null allele
antimorph
neomorph
synthetic lethality
enhancer
maternal effect genes
nucleosomes
locus control region
DNA hemimethylase
euchromatin
X-inactivation
roX RNA
polyadenylation site
U2 snRNP
Ran GTPase
IRES
aminoacyl tRNA
exosome
dicer
siRNA
STS
LOD scores
allelic association
phenocopy
polygenic determination
amorph
hypomorph
dominant negative
nonallelic noncomplementation
core promoter
gap genes
DNase sensitivity
core histones
de novo methylation
position effect variegation
Barr bodies
imprinting
spliceosome
RNA editing
importins
eIF2
peptidyl tRNA
EJC
RISC
ubiquitin
radiation hybrid mapping
autozygosity
linkage disequilibrium
penetrance
allelic series
haploinsufficient
hypermorph
ectopic expression
forward (and reverse) genetics
Know features associated with active and inactive chromatin.
Be familiar with sex determination in Drosophila melanogaster.
Be able to distinguish linkage maps, physical maps and cytological maps and know methods that
allow each type of map to be correlated with the others.
Be able to look at a pedigree and identify recombinants and nonrecombinants, alleles identical by
descent and informative vs. uninformative meioses. Be able to describe or recognize pedigrees
showing maternal imprinting, paternal imprinting and anticipation.
Be familiar with the definition of a LOD score and how it might change with different models.
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