Why is it thought that left-handers live less long? Chris McManus University College London Statistical Fallacies in Research & the Media Royal Statistical Society 1st June 2015 • And the other four reasons? That can wait until later… Stanley Coren and Diane Halpern, 1988, Nature, “Do right-handers live longer?” “[a]bout 2 per cent more right-handers than lefthanders survive at each age (p<.001) (see figure)”. t-test, t=0.62, 1706 df, p=0.537 Diff= 35 weeks Is this difficult to interpret? Several letters, but none on the statistics… Nature, 16th June 1988 Nature, 18th April 1991 Nature, 18th April 1991 New England Journal of Medicine, April 4th, 1991 New England Journal of Medicine, Oct 3rd , 1991 Handedness evaluated in 1976 or 1978; followed up in 1988 Ken Rothman, Epidemiologist The problem with the Halpern and Coren study. • They knew the ages of – dead right-handers, and – dead left-handers • But, they did not know the ages of – living right-handers and – living left-handers • If living left-handers are also younger than living righthanders – Secular trend – But no effect on survival • Halpern and Coren’s study was a ‘death cohort study’ – Death cohorts always confound secular trends and age at death – ‘Birth cohort studies’ do not suffer from that problem. Are there secular trends in handedness? 1 6 % Secular trends 1 4 % F e m a l e s 1 2 % M a l e s 1 0 % 8 % 6 % 4 % 2 % 0 % 1 9 0 0 1 9 1 0 1 9 2 0 1 9 3 0 1 9 4 0 1 9 5 0 1 9 6 0 1 9 7 0 Y e a r o f B i r t h G i l b e r t & W y s o c k i ( 1 9 9 2 ) N e u r o p s y c h o l o g i a , 3 0 : 6 0 1 8 0 % Sex2 differences F e m a l e s M a l e s 1 0 % 9 % 8 % 7 % 6 % 5 % 4 % 3 % 2 % 1 9 0 0 1 9 1 0 1 9 2 0 1 9 3 0 1 9 4 0 1 9 5 0 1 9 6 0 1 9 7 0 Y e a r o f B i r t h G i l b e r t & W y s o c k i ( 1 9 9 2 ) N e u r o p s y c h o l o g i a , 3 0 : 6 0 1 8 Combining all the nineteenth century data 20% 10% 9% 8% 7% 6% 5% 4% 3% 2% 1% 1760 1780 1800 1820 1840 1860 1880 1900 1920 1940 1960 1980 2000 So is this problem only found in studies of handedness? Lancet, 1994 Err, No…! BMJ, 1996, Christmas edition Finally, we committed a statistical howler in our Christmas issue. We published a paper that concluded from obituary data that doctors from the Indian subcontinent and anaesthetists died young. Chris McManus suggests that the same data might have shown that doctors who had Oasis CDs or who were called Tracy or Kevin also died young (p 1132). It's a problem of denominators. There were none in the paper, and the seemingly increased risk of doctors from the Indian subcontinent and anaesthetists of dying young is probably because the population from which they come is young. Many people wrote to point out the error. We are comforted by the Lancet having made the same mistake two years ago. Finally, we committed a statistical howler in our Christmas issue. We published a paper that concluded from obituary data that doctors from the Indian subcontinent and anaesthetists died young. Chris McManus suggests that the same data might have shown that doctors who had Oasis CDs or who were called Tracy or Kevin also died young (p 1132). It's a problem of denominators. There were none in the paper, and the seemingly increased risk of doctors from the Indian subcontinent and anaesthetists of dying young is probably because the population from which they come is young. Many people wrote to point out the error. We are comforted by the Lancet having made the same mistake two years ago. Finally, we committed a statistical howler in our Christmas issue. We published a paper that concluded from obituary data that doctors from the Indian subcontinent and anaesthetists died young. Chris McManus suggests that the same data might have shown that doctors who had Oasis CDs or who were called Tracy or Kevin also died young (p 1132). It's a problem of denominators. There were none in the paper, and the seemingly increased risk of doctors from the Indian subcontinent and anaesthetists of dying young is probably because the population from which they come is young. Many people wrote to point out the error. We are comforted by the Lancet having made the same mistake two years ago. Finally, we committed a statistical howler in our Christmas issue. We published a paper that concluded from obituary data that doctors from the Indian subcontinent and anaesthetists died young. Chris McManus suggests that the same data might have shown that doctors who had Oasis CDs or who were called Tracy or Kevin also died young (p 1132). It's a problem of denominators. There were none in the paper, and the seemingly increased risk of doctors from the Indian subcontinent and anaesthetists of dying young is probably because the population from which they come is young. Many people wrote to point out the error. We are comforted by the Lancet having made the same mistake two years ago. Finally, we committed a statistical howler in our Christmas issue. We published a paper that concluded from obituary data that doctors from the Indian subcontinent and anaesthetists died young. Chris McManus suggests that the same data might have shown that doctors who had Oasis CDs or who were called Tracy or Kevin also died young (p 1132). It's a problem of denominators. There were none in the paper, and the seemingly increased risk of doctors from the Indian subcontinent and anaesthetists of dying young is probably because the population from which they come is young. Many people wrote to point out the error. We are comforted by the Lancet having made the same mistake two years ago. And yet still they keep coming… This is clearly a modern myth (and there seems to be no sign of it before 1988). So why is it so prevalent and so resistant to evidence? • So what were the other four reasons? • #4: They’re more likely to go insane • #3: They’re screwed at school • #2: They’re more easily scared… • #1: Hating them is ingrained in our culture