RESITRA
Red de EStudio
de la Infección
en el
TRAsplante
Research network for the study of
infection in transplantation
Dr Jordi Carratala
Hospital de Bellvitge. Barcelona
DEFINITION
AND
OBJECTIVES
RESITRA
• Network of specialists in different fields of
transplantation medicine, belonging to the main
hospitals that perform SOT and BMT in Spain.
•
•
•
•
Sponsored by Spanish Ministry of Health
16 participating centers and 3 reference laboratories
Surveillance began September 2003
All transplant recipients were recorded in the
database
JUAN
CANALEJO
CRUCES
Doce Octubre
Ramón y Cajal
Gregorio Marañón
Puerta de Hierro
Princesa
VIRGEN DEL ROCÍO
REINA SOFIA
HVH
Clinic
Bellvitge
Sant Pau
Tries i Pujol
LA FE
16 centers
50% BMT
SON DURETA
OBJECTIVES
1. Infection knowledge in the transplant setting
2. Use of new immunological and molecular tools for the
diagnosis and treatment of infection in transplant
recipients
3. High-level training in biomedical research for
physicians, nursing staff and technicians
4. Network for clinical trials
5. Contact with other european groups or networks
RESITRA
GENERAL COORDINATOR
Dr. Albert Pahissa
Hospital Universitari Vall d'Hebron
GENERAL SECRETARY
Dr. Joan Gavaldà
Hospital Universitari Vall d'Hebron
SCIENTIFIC COMMITTEE
Drs. Aguado, Ausina, Bouza, Carreras, Cuervas-Mon,
Pahissa, Pumarola, Rodríguez-Tudela
Information and Documentation Unit
Clinical Coordinator
Dr. José Mª Aguado
Hospital Doce de Octubre
Methodology/Epidemiology Assessor
Clinical Investigator
Laboratory Coordinator
Dr. Tomàs Pumarola
Hospital Clínic
Coordinating Advisor for the Site Laboratory
CNM - ISCIII
Dr. Juan Luis Rodríguez Tudela
Clinical Investigator
Laboratory Technician
Coordinator Site 1 -Hospital x
Coordinator Site 2 -Hospital x
Coordinator Site 3 -Hospital x
Coordinator Site n -Hospital x
Clinical Investigator
Clinical Research Nurse
Laboratory Technician
Clinical Investigator
Clinical Research Nurse
Laboratory Technician
Clinical Investigator
Clinical Research Nurse
Laboratory Technician
Clinical Investigator
clinical Research Nurse
Laboratory Technician
METHODS
Tools for developping the network
DATABASE
Levels of Information
BANK
Basic: Registry
Advanced:
Serum
Plasma
DNA
Microorganisms
Tissues
Dissemination Interconnection
knowledge
basic research
formulate new
hypothesis
Teaching
European
groups
Clinical
trials
DATABASE
Other medical-surgical
complications
REJECTION
Bacterial Infection
Viral Infection
FOLLOW
-UP
Fungal Infection
to
Other Infection
2y
PERITRANSPLANT
PRETRANSPLANT
Sample Bank
DATABASE
INFORMATIC TOOL
Web
INFORMATIC TOOL
Applicative
HERRAMIENTA INFORMATICA
Applicative on-line
HERRAMIENTA INFORMATICA
Applicative on-line
INFORMATIC TOOL
Databases Forms
INFORMATIC TOOL
Databases Forms
1-09-03//1-03-05 * 30-04-05//15-01-06
6000
5596
4000
3589
2703
2000
0
4179
0
1-9-03
Est
31-09-04
1-3-05
1-6-05
15/01/2006
RESITRA. 1-09-03 // 01-03-05
944
283
167
979
1330
PANCREAS
53
RESULTS
RESITRA
•
•
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San-Juan R, Aguado JM, Lumbreras C, Fortun J, Len O, Muñoz P, Montejo M,
Moreno A, Cordero E, Blanes M, Ramos A, de la Torre-Cisneros J, Lopez-Medrano
F,
Carratala J, Moreno E; RESITRA-REIPI Network, Spain. Universal
Prophylaxis With Fluconazole for the Prevention of Early Invasive Fungal
Infection in Low-Risk Liver Transplant Recipients. Transplantation. 2011
Aug 15;92(3):346-350.
Fortun J, Martin-Davila P, Pascual J, Cervera C, Moreno A, Gavalda J, Aguado
JM, Pereira P, Gurguí M, Carratala J, Fogueda M, Montejo M, Blasco F, Bou G,
Torre-Cisneros J; RESITRA Transplant Network. Immunosuppressive therapy
and infection after kidney transplantation. Transpl Infect Dis. 2010
Oct;12(5):397-405.
Torre-Cisneros J, Doblas A, Aguado JM, San Juan R, Blanes M, Montejo M,
Cervera C, Len O, Carratala J, Cisneros JM, Bou G, Muñoz P, Ramos A, Gurgui
M,Borrell N, Fortún J, Moreno A, Gavalda J; Spanish Network for Research in
Infectious Diseases. Tuberculosis after solid-organ transplant: incidence, risk
factors, and clinical characteristics in the RESITRA (Spanish Network of
Infection in Transplantation) cohort. Clin Infect Dis. 2009 Jun
15;48(12):1657-65.
RESITRA
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Len O, Gavaldà J, Blanes M, Montejo M, San Juan R, Moreno A, Carratalà J, de la
Torre-Cisneros J, Bou G, Cordero E, Muñoz P, Cuervas-Mons V, Alvarez MT,
Borrell N, Fortun J, Pahissa A; Spanish Research Network for the Study of
Infection in Transplantation. Donor infection and transmission to the recipient
of a solid allograft. Am J Transplant. 2008 Nov;8(11):2420-5.
San Juan R, Aguado JM, Lumbreras C, Fortun J, Muñoz P, Gavalda J, LopezMedrano F, Montejo M, Bou G, Blanes M, Ramos A, Moreno A, Torre-Cisneros J,
Carratalá J; RESITRA Network of the Spanish Study Group of Infection in
Transplantation. Impact of current transplantation management on the
development of cytomegalovirus disease after renal transplantation. Clin
Infect Dis. 2008 Oct 1;47(7):875-82. .
Ramos A, Asensio A, Muñez E, Torre-Cisneros J, Blanes M, Carratalá J, Segovia
J, Munoz P, Cisneros JM, Bou G, Aguado JM, Cervera C, Gurgui MM. Incisional
surgical infection in heart transplantation. Transpl Infect Dis. 2008
Jul;10(4):298-302.
Ramos A, Asensio A, Muñez E, Torre-Cisneros J, Montejo M, Aguado JM, Cofán
F, Carratalá J, Len O, Cisneros JM. Incisional surgical site infection in kidney
transplantation. Urology. 2008 Jul;72(1):119-23.
RESITRA
•
•
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•
Len O, Gavaldà J, Aguado JM, Borrell N, Cervera C, Cisneros JM, Cuervas-Mons
V, Gurguí M, Martin-Dávila P, Montejo M, Muñoz P, Bou G, Carratalà J, TorreCisneros J, Pahissa A; RESITRA. Valganciclovir as treatment for
cytomegalovirus disease in solid organ transplant recipients. Clin Infect Dis.
2008 Jan 1;46(1):20-7.
Moreno A, Cervera C, Gavaldá J, Rovira M, de la Cámara R, Jarque I, Montejo M,
de la Torre-Cisneros J, Miguel Cisneros J, Fortún J, López-Medrano F, Gurguí M,
Muñoz P, Ramos A, Carratalá J. Bloodstream infections among transplant
recipients: results of a nationwide surveillance in Spain. Am J Transplant.
2007 Nov;7(11):2579-86.
Len O, Gavaldà J, Blanes M, Montejo M, San Juan R, Moreno A, Carratalà J, de la
Torre-Cisneros J, Bou G, Cordero E, Muñoz P, Cuervas-Mons V, Alvarez MT,
Borrell N, Fortun J, Pahissa A; Spanish Research Network for the Study of
Infection in Transplantation. Donor infection and transmission to the recipient
of a solid allograft. Am J Transplant. 2008 Nov;8(11):2420-5.
San Juan R, Aguado JM, Lumbreras C, Fortun J, Muñoz P, Gavalda J, LopezMedrano F, Montejo M, Bou G, Blanes M, Ramos A, Moreno A, Torre-Cisneros J,
Carratalá J; RESITRA Network of the Spanish Study Group of Infection in
Transplantation. Impact of current transplantation management on the
development of cytomegalovirus disease after renal transplantation. Clin
Infect Dis. 2008 Oct 1;47(7):875-82.
RESITRA
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Aguilar-Guisado M, Givaldá J, Ussetti P, Ramos A, Morales P, Blanes M, Bou G, de
la Torre-Cisneros J, Román A, Borro JM, Lama R, Cisneros JM; RESITRA cohort.
Pneumonia after lung transplantation in the RESITRA Cohort: a multicenter
prospective study. Am J Transplant. 2007 Aug;7(8):1989-96.
San Juan R, Aguado JM, Lumbreras C, Díaz-Pedroche C, López-Medrano F,
Lizasoain M, Gavalda J, Montejo M, Moreno A, Gurguí M, Torre-Cisneros J;
RESITRA Network, Spain,. Incidence, clinical characteristics and risk factors
of late infection in solid organ transplant recipients: data from the
RESITRA study group. Am J Transplant. 2007 Apr;7(4):964-71.
Garrido RS, Aguado JM, Díaz-Pedroche C, Len O, Montejo M, Moreno A, Gurguí
M, Torre-Cisneros J, Pareja F, Segovia J, Garcia M, Lumbreras C. A review of
critical periods for opportunistic infection in the new transplantation era.
Transplantation. 2006 Dec 15;82(11):1457-62.
Gavalda J, Len O, San Juan R, Aguado JM, Fortun J, Lumbreras C, Moreno A,
Munoz P, Blanes M, Ramos A, Rufi G, Gurgui M, Torre-Cisneros J, Montejo M,
Cuenca-Estrella M, Rodriguez-Tudela JL, Pahissa A; RESITRA (Spanish Network
for Research on Infection in Transplantation). Risk factors for invasive
aspergillosis in solid-organ transplant recipients: a case-control study. Clin
Infect Dis. 2005 Jul 1;41(1):52-9.